Single-neuron dynamics in human focal epilepsy

Wilson Truccolo, Jacob A. Donoghue, Leigh R. Hochberg, Emad N. Eskandar, Joseph R. Madsen, William S. Anderson, Emery N. Brown, Eric Halgren, Sydney S. Cash

Research output: Contribution to journalArticle

258 Citations (Scopus)

Abstract

Epileptic seizures are traditionally characterized as the ultimate expression of monolithic, hypersynchronous neuronal activity arising from unbalanced runaway excitation. Here we report the first examination of spike train patterns in large ensembles of single neurons during seizures in persons with epilepsy. Contrary to the traditional view, neuronal spiking activity during seizure initiation and spread was highly heterogeneous, not hypersynchronous, suggesting complex interactions among different neuronal groups even at the spatial scale of small cortical patches. In contrast to earlier stages, seizure termination is a nearly homogenous phenomenon followed by an almost complete cessation of spiking across recorded neuronal ensembles. Notably, even neurons outside the region of seizure onset showed significant changes in activity minutes before the seizure. These findings suggest a revision of current thinking about seizure mechanisms and point to the possibility of seizure prevention based on spiking activity in neocortical neurons.

Original languageEnglish (US)
Pages (from-to)635-643
Number of pages9
JournalNature Neuroscience
Volume14
Issue number5
DOIs
StatePublished - May 1 2011
Externally publishedYes

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Partial Epilepsy
Seizures
Neurons
Epilepsy
Homeless Youth

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Truccolo, W., Donoghue, J. A., Hochberg, L. R., Eskandar, E. N., Madsen, J. R., Anderson, W. S., ... Cash, S. S. (2011). Single-neuron dynamics in human focal epilepsy. Nature Neuroscience, 14(5), 635-643. https://doi.org/10.1038/nn.2782

Single-neuron dynamics in human focal epilepsy. / Truccolo, Wilson; Donoghue, Jacob A.; Hochberg, Leigh R.; Eskandar, Emad N.; Madsen, Joseph R.; Anderson, William S.; Brown, Emery N.; Halgren, Eric; Cash, Sydney S.

In: Nature Neuroscience, Vol. 14, No. 5, 01.05.2011, p. 635-643.

Research output: Contribution to journalArticle

Truccolo, W, Donoghue, JA, Hochberg, LR, Eskandar, EN, Madsen, JR, Anderson, WS, Brown, EN, Halgren, E & Cash, SS 2011, 'Single-neuron dynamics in human focal epilepsy', Nature Neuroscience, vol. 14, no. 5, pp. 635-643. https://doi.org/10.1038/nn.2782
Truccolo W, Donoghue JA, Hochberg LR, Eskandar EN, Madsen JR, Anderson WS et al. Single-neuron dynamics in human focal epilepsy. Nature Neuroscience. 2011 May 1;14(5):635-643. https://doi.org/10.1038/nn.2782
Truccolo, Wilson ; Donoghue, Jacob A. ; Hochberg, Leigh R. ; Eskandar, Emad N. ; Madsen, Joseph R. ; Anderson, William S. ; Brown, Emery N. ; Halgren, Eric ; Cash, Sydney S. / Single-neuron dynamics in human focal epilepsy. In: Nature Neuroscience. 2011 ; Vol. 14, No. 5. pp. 635-643.
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