Single dose X-irradiation and concomitant hyperthermia on a murine fibrosarcoma

E. W. Hahn, A. A. Alfieri, J. H. Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The objectives of this study were to quantitate the effects of local tumor hyperthermia (LTH) and concomitant X-irradiation (RAD) on a moderately radio-resistant murine fibrosarcoma in situ. Comparisons were made to the combined treatment response on the Ridgway osteogenic sarcoma, a radiosensitive tumor previously used in the authors' laboratory and to establish the Meth-A fibrosarcoma as a model system for combined modality studies. 1.0 cm3 tumors were exposed to single doses of RAD ranging from 0.5-3.8 krad alone or 0.5-2.3 krad in combination with LTH (water bath at 43.1 ± .05 for 20 min) applied immediately postirradiation. LTH significantly enhanced the action of radiation as measured by tumor volume analysis, mean survival time and cures. The ratio of radiation doses vs. RAD + LTH required to produce an equivalent response ranged from 1.4 to 2.5 depending upon the endpoints evaluated. These findings are consistent with single dose studies on the radiosensitive Ridgway osteogenic sarcoma and suggest that the tumoricidal effectiveness of combination radiation and hyperthermia cannot be predicted on the basis of the radiation alone responsiveness of tumor.

Original languageEnglish (US)
Pages (from-to)2591-2595
Number of pages5
JournalCancer
Volume42
Issue number6
StatePublished - 1978
Externally publishedYes

Fingerprint

Fibrosarcoma
Fever
Induced Hyperthermia
Neoplasms
Radiation
Osteosarcoma
Tumor Burden
Radio
Baths
Water

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Hahn, E. W., Alfieri, A. A., & Kim, J. H. (1978). Single dose X-irradiation and concomitant hyperthermia on a murine fibrosarcoma. Cancer, 42(6), 2591-2595.

Single dose X-irradiation and concomitant hyperthermia on a murine fibrosarcoma. / Hahn, E. W.; Alfieri, A. A.; Kim, J. H.

In: Cancer, Vol. 42, No. 6, 1978, p. 2591-2595.

Research output: Contribution to journalArticle

Hahn, EW, Alfieri, AA & Kim, JH 1978, 'Single dose X-irradiation and concomitant hyperthermia on a murine fibrosarcoma', Cancer, vol. 42, no. 6, pp. 2591-2595.
Hahn, E. W. ; Alfieri, A. A. ; Kim, J. H. / Single dose X-irradiation and concomitant hyperthermia on a murine fibrosarcoma. In: Cancer. 1978 ; Vol. 42, No. 6. pp. 2591-2595.
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