Single-copy flanking sequences in human histone gene clusters map to chromosomes 1 and 6

Beverly S. Allen, Janet L. Stein, Gary S. Stein, Harry Ostrer

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Two single-copy sequences flanking two different human histone gene clusters were used as probes to map these clusters by in situ hybridization. pFF435B, a unique sequence subclone derived from a lambda genomic clone (λHHG55) containing H2A, H2B, H3, and H4 genes, mapped to chromosome 1q21 (χ2 = 120.99, P < 0.001). pST519E, a single-copy sequence derived from a lambda genomic clone (λHHG17) containing only H3 and H4 genes, mapped to chromosome 6p21 (χ2 = 112.62, P < 0.001). These findings agree with previous assignments of human histone genes to chromosomes 1 and 6 and demonstrate that the single-copy flanking sequences in different human histone gene clusters are unique for different chromosomes.

Original languageEnglish (US)
Pages (from-to)486-488
Number of pages3
JournalGenomics
Volume10
Issue number2
DOIs
StatePublished - Jun 1991
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Single-copy flanking sequences in human histone gene clusters map to chromosomes 1 and 6'. Together they form a unique fingerprint.

  • Cite this