Single-copy flanking sequences in human histone gene clusters map to chromosomes 1 and 6

Beverly S. Allen, Janet L. Stein, Gary S. Stein, Harry Ostrer

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Two single-copy sequences flanking two different human histone gene clusters were used as probes to map these clusters by in situ hybridization. pFF435B, a unique sequence subclone derived from a lambda genomic clone (λHHG55) containing H2A, H2B, H3, and H4 genes, mapped to chromosome 1q21 (χ2 = 120.99, P < 0.001). pST519E, a single-copy sequence derived from a lambda genomic clone (λHHG17) containing only H3 and H4 genes, mapped to chromosome 6p21 (χ2 = 112.62, P < 0.001). These findings agree with previous assignments of human histone genes to chromosomes 1 and 6 and demonstrate that the single-copy flanking sequences in different human histone gene clusters are unique for different chromosomes.

Original languageEnglish (US)
Pages (from-to)486-488
Number of pages3
JournalGenomics
Volume10
Issue number2
DOIs
StatePublished - 1991
Externally publishedYes

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Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 1
Multigene Family
Histones
Chromosomes, Human, Pair 2
Clone Cells
Genes
In Situ Hybridization
Chromosomes

ASJC Scopus subject areas

  • Genetics

Cite this

Single-copy flanking sequences in human histone gene clusters map to chromosomes 1 and 6. / Allen, Beverly S.; Stein, Janet L.; Stein, Gary S.; Ostrer, Harry.

In: Genomics, Vol. 10, No. 2, 1991, p. 486-488.

Research output: Contribution to journalArticle

Allen, Beverly S. ; Stein, Janet L. ; Stein, Gary S. ; Ostrer, Harry. / Single-copy flanking sequences in human histone gene clusters map to chromosomes 1 and 6. In: Genomics. 1991 ; Vol. 10, No. 2. pp. 486-488.
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