@article{b3c9679f144d4492a8ed389da1cee231,
title = "Single-cell RNA sequencing for the study of lupus nephritis",
abstract = "Single-cell RNA sequencing (scRNA-seq) has recently undergone rapid advances in the development of this technology, leading to high throughput and accelerating discovery in many biological systems and diseases. The single-cell resolution of the technique allows for the investigation of heterogeneity in cell populations, and the pinpointing of pathological populations contributing to disease. Here we review the development of scRNA-seq technology and the analysis that has evolved with the ever-increasing throughput. Finally, we highlight recent applications of scRNA-seq to understand the molecular pathogenesis of lupus and lupus nephritis.",
keywords = "inflammation, lupus nephritis, systemic lupus erythematosus",
author = "Evan Der and Hemant Suryawanshi and Jill Buyon and Thomas Tuschl and Chaim Putterman",
note = "Funding Information: Funding Funding was provided through grants from the National Institutes of Health (UH2-AR067676, UH2-AR067677, UH2-AR067679, UH2-AR067681, UH2-AR067685, UH2-AR067688, UH2-AR067689, UH2-AR067690, UH2-AR067691, UH2-AR067694, and UM2-AR067678). Competing interests None declared. Patient consent for publication Not required. Provenance and peer review Commissioned; externally peer reviewed. open access This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0 Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2019",
month = jun,
day = "1",
doi = "10.1136/lupus-2019-000329",
language = "English (US)",
volume = "6",
journal = "Lupus Science and Medicine",
issn = "2053-8790",
publisher = "BMJ Publishing Group",
number = "1",
}