Single-cell RNA sequencing for the study of lupus nephritis

Evan Der, Hemant Suryawanshi, Jill Buyon, Thomas Tuschl, Chaim Putterman

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Single-cell RNA sequencing (scRNA-seq) has recently undergone rapid advances in the development of this technology, leading to high throughput and accelerating discovery in many biological systems and diseases. The single-cell resolution of the technique allows for the investigation of heterogeneity in cell populations, and the pinpointing of pathological populations contributing to disease. Here we review the development of scRNA-seq technology and the analysis that has evolved with the ever-increasing throughput. Finally, we highlight recent applications of scRNA-seq to understand the molecular pathogenesis of lupus and lupus nephritis.

Original languageEnglish (US)
Article numbere000329
JournalLupus Science and Medicine
Volume6
Issue number1
DOIs
StatePublished - Jun 1 2019

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Keywords

  • inflammation
  • lupus nephritis
  • systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology

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