Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease

Alice D. Lam, Gina Deck, Alica Goldman, Emad N. Eskandar, Jeffrey Noebels, Andrew J. Cole

Research output: Contribution to journalArticle

73 Scopus citations


We directly assessed mesial temporal activity using intracranial foramen ovale electrodes in two patients with Alzheimer's disease (AD) without a history or EEG evidence of seizures. We detected clinically silent hippocampal seizures and epileptiform spikes during sleep, a period when these abnormalities were most likely to interfere with memory consolidation. The findings in these index cases support a model in which early development of occult hippocampal hyperexcitability may contribute to the pathogenesis of AD.

Original languageEnglish (US)
Pages (from-to)678-680
Number of pages3
JournalNature Medicine
Issue number6
StatePublished - Jun 1 2017


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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