We directly assessed mesial temporal activity using intracranial foramen ovale electrodes in two patients with Alzheimer's disease (AD) without a history or EEG evidence of seizures. We detected clinically silent hippocampal seizures and epileptiform spikes during sleep, a period when these abnormalities were most likely to interfere with memory consolidation. The findings in these index cases support a model in which early development of occult hippocampal hyperexcitability may contribute to the pathogenesis of AD.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Jun 1 2017|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)