Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease

Alice D. Lam; Gina Deck; Alica Goldman; Emad N. Eskandar; Jeffrey Noebels; Andrew J. Cole

doi:10.1038/nm.4330

Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease

Alice D. Lam, Gina Deck, Alica Goldman, Emad N. Eskandar, Jeffrey Noebels, Andrew J. Cole

Research output: Contribution to journal › Article › peer-review

193 Scopus citations

Abstract

We directly assessed mesial temporal activity using intracranial foramen ovale electrodes in two patients with Alzheimer's disease (AD) without a history or EEG evidence of seizures. We detected clinically silent hippocampal seizures and epileptiform spikes during sleep, a period when these abnormalities were most likely to interfere with memory consolidation. The findings in these index cases support a model in which early development of occult hippocampal hyperexcitability may contribute to the pathogenesis of AD.

Original language	English (US)
Pages (from-to)	678-680
Number of pages	3
Journal	Nature Medicine
Volume	23
Issue number	6
DOIs	https://doi.org/10.1038/nm.4330
State	Published - Jun 1 2017
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease",

abstract = "We directly assessed mesial temporal activity using intracranial foramen ovale electrodes in two patients with Alzheimer's disease (AD) without a history or EEG evidence of seizures. We detected clinically silent hippocampal seizures and epileptiform spikes during sleep, a period when these abnormalities were most likely to interfere with memory consolidation. The findings in these index cases support a model in which early development of occult hippocampal hyperexcitability may contribute to the pathogenesis of AD.",

author = "Lam, {Alice D.} and Gina Deck and Alica Goldman and Eskandar, {Emad N.} and Jeffrey Noebels and Cole, {Andrew J.}",

note = "Funding Information: This work was supported by NIH-NINDS R25-NS065743 (A.D.L.), the Massachusetts General Hospital Executive Committee on Research (A.D.L.), NIH-NINDS U01-NS090362 (A.G.), Citizens United for Research in Epilepsy (A.G.), NIH-NINDS R01-NS029709 (J.N.), and the Blue Bird Circle Foundation (J.N.). Publisher Copyright: {\textcopyright} 2017 Nature America, Inc., part of Springer Nature. All rights reserved.",

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AU - Goldman, Alica

AU - Eskandar, Emad N.

AU - Noebels, Jeffrey

AU - Cole, Andrew J.

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N2 - We directly assessed mesial temporal activity using intracranial foramen ovale electrodes in two patients with Alzheimer's disease (AD) without a history or EEG evidence of seizures. We detected clinically silent hippocampal seizures and epileptiform spikes during sleep, a period when these abnormalities were most likely to interfere with memory consolidation. The findings in these index cases support a model in which early development of occult hippocampal hyperexcitability may contribute to the pathogenesis of AD.

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Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease

Abstract

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