Silent corticotroph adenoma with multiple cysts: Pars intermedia tumor?

Hiroshi Nishioka, Asao Hirano, Sylvia L. Asa

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Abstract

A silent corticotroph adenoma with multiple cysts was found incidentally at autopsy. By immunohistochemistry, most of the adenoma cells contained reactivity for adrenocorticotropic hormone and beta-endorphin; a few cells stained for beta-subunit of luteinizing hormone. The cysts, interspersed within the tumor, were lined by cuboidal epithelium with foci of stratified squamous epithelium. The lining cells contained immunoreactive keratin; some cells were positive for S-100 protein or glial fibrillary acidic protein, and a few cells were also immuno-stained for adrenocorticotropic hormone and beta-endorphin. It is suggested that this tumor may represent a neoplasm of pars intermedia derivation.

Original languageEnglish (US)
Pages (from-to)47-51
Number of pages5
JournalEndocrine Pathology
Volume3
Issue number1
DOIs
Publication statusPublished - Mar 1 1992

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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