Silent corticotroph adenoma with multiple cysts: Pars intermedia tumor?

Hiroshi Nishioka; Asao Hirano; Sylvia L. Asa

doi:10.1007/BF02921343

Silent corticotroph adenoma with multiple cysts: Pars intermedia tumor?

Hiroshi Nishioka, Asao Hirano, Sylvia L. Asa

Pathology

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Abstract

A silent corticotroph adenoma with multiple cysts was found incidentally at autopsy. By immunohistochemistry, most of the adenoma cells contained reactivity for adrenocorticotropic hormone and beta-endorphin; a few cells stained for beta-subunit of luteinizing hormone. The cysts, interspersed within the tumor, were lined by cuboidal epithelium with foci of stratified squamous epithelium. The lining cells contained immunoreactive keratin; some cells were positive for S-100 protein or glial fibrillary acidic protein, and a few cells were also immuno-stained for adrenocorticotropic hormone and beta-endorphin. It is suggested that this tumor may represent a neoplasm of pars intermedia derivation.

Original language	English (US)
Pages (from-to)	47-51
Number of pages	5
Journal	Endocrine Pathology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1007/BF02921343
State	Published - Mar 1992

ASJC Scopus subject areas

Pathology and Forensic Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1007/BF02921343

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title = "Silent corticotroph adenoma with multiple cysts: Pars intermedia tumor?",

abstract = "A silent corticotroph adenoma with multiple cysts was found incidentally at autopsy. By immunohistochemistry, most of the adenoma cells contained reactivity for adrenocorticotropic hormone and beta-endorphin; a few cells stained for beta-subunit of luteinizing hormone. The cysts, interspersed within the tumor, were lined by cuboidal epithelium with foci of stratified squamous epithelium. The lining cells contained immunoreactive keratin; some cells were positive for S-100 protein or glial fibrillary acidic protein, and a few cells were also immuno-stained for adrenocorticotropic hormone and beta-endorphin. It is suggested that this tumor may represent a neoplasm of pars intermedia derivation.",

author = "Hiroshi Nishioka and Asao Hirano and Asa, {Sylvia L.}",

year = "1992",

month = mar,

doi = "10.1007/BF02921343",

language = "English (US)",

volume = "3",

pages = "47--51",

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T1 - Silent corticotroph adenoma with multiple cysts

T2 - Pars intermedia tumor?

AU - Nishioka, Hiroshi

AU - Hirano, Asao

AU - Asa, Sylvia L.

PY - 1992/3

Y1 - 1992/3

N2 - A silent corticotroph adenoma with multiple cysts was found incidentally at autopsy. By immunohistochemistry, most of the adenoma cells contained reactivity for adrenocorticotropic hormone and beta-endorphin; a few cells stained for beta-subunit of luteinizing hormone. The cysts, interspersed within the tumor, were lined by cuboidal epithelium with foci of stratified squamous epithelium. The lining cells contained immunoreactive keratin; some cells were positive for S-100 protein or glial fibrillary acidic protein, and a few cells were also immuno-stained for adrenocorticotropic hormone and beta-endorphin. It is suggested that this tumor may represent a neoplasm of pars intermedia derivation.

AB - A silent corticotroph adenoma with multiple cysts was found incidentally at autopsy. By immunohistochemistry, most of the adenoma cells contained reactivity for adrenocorticotropic hormone and beta-endorphin; a few cells stained for beta-subunit of luteinizing hormone. The cysts, interspersed within the tumor, were lined by cuboidal epithelium with foci of stratified squamous epithelium. The lining cells contained immunoreactive keratin; some cells were positive for S-100 protein or glial fibrillary acidic protein, and a few cells were also immuno-stained for adrenocorticotropic hormone and beta-endorphin. It is suggested that this tumor may represent a neoplasm of pars intermedia derivation.

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JO - Endocrine Pathology

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Silent corticotroph adenoma with multiple cysts: Pars intermedia tumor?

Abstract

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