Signs of central nervous system dysfunction in obsessive-compulsive disorder

Eric Hollander, Erica Schifftnan, Barry Cohen, Maria A. Rivera-Stein, Wilma Rosen, Jack M. Gorman, Abby J. Fyer, Laszlo Papp, Michael R. Liebowitz

Research output: Contribution to journalArticle

201 Citations (Scopus)

Abstract

Obsessive-compulsive disorder (OCD) has been linked to altered neurological function following head trauma, encephalitis, abnormal birth events, and Gilies de la Tourette's syndrome. Abnormalities in computed tomographic scans, electroencephalograms, positron emission tomographic scans, and evoked potentials have been described in this disorder, but are neither consistent nor pathognomonic of OCD. Neurological soft signs are nonlocalizing signs of deviant performance on a motor or sensory test where no other sign of a neurological lesion Is present. We studied 41 medication-free patients with OCD who met DSM-III-R criteria, as well as 20 normal controls, matched for age, sex, and handedness, on 20 Individual tasks that involved fine motor coordination, involuntary movements, and sensory and visuospatial function. There were significantly more signs of central nervous system dysfunction In the OCD group, as shown by abnormalities in fine motor coordination, involuntary and mirror movements, and visuospatial function. An excess of findings on the left side of the body and abnormalities of cube drawing may suggest right hemispheric dysfunction in a sub-group of patients with OCD. Soft signs correlated with a severity of obsessions. There was also a correlation between abnormalities In visual memory and recognition on neuropsychological testing and total soft signs. These findings provided additional evidence for a neurological deficit In some patients with OCD. However, further comparisons with other psychiatric populations are needed to determine whether these findings are unique to OCD or are a property of other psychiatric disorders as well.

Original languageEnglish (US)
Pages (from-to)27-32
Number of pages6
JournalArchives of General Psychiatry
Volume47
Issue number1
StatePublished - 1990
Externally publishedYes

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Obsessive-Compulsive Disorder
Central Nervous System
Dyskinesias
Psychiatry
Obsessive Behavior
Tourette Syndrome
Functional Laterality
Encephalitis
Craniocerebral Trauma
Evoked Potentials
Diagnostic and Statistical Manual of Mental Disorders
Electroencephalography
Parturition
Electrons
Population

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Hollander, E., Schifftnan, E., Cohen, B., Rivera-Stein, M. A., Rosen, W., Gorman, J. M., ... Liebowitz, M. R. (1990). Signs of central nervous system dysfunction in obsessive-compulsive disorder. Archives of General Psychiatry, 47(1), 27-32.

Signs of central nervous system dysfunction in obsessive-compulsive disorder. / Hollander, Eric; Schifftnan, Erica; Cohen, Barry; Rivera-Stein, Maria A.; Rosen, Wilma; Gorman, Jack M.; Fyer, Abby J.; Papp, Laszlo; Liebowitz, Michael R.

In: Archives of General Psychiatry, Vol. 47, No. 1, 1990, p. 27-32.

Research output: Contribution to journalArticle

Hollander, E, Schifftnan, E, Cohen, B, Rivera-Stein, MA, Rosen, W, Gorman, JM, Fyer, AJ, Papp, L & Liebowitz, MR 1990, 'Signs of central nervous system dysfunction in obsessive-compulsive disorder', Archives of General Psychiatry, vol. 47, no. 1, pp. 27-32.
Hollander E, Schifftnan E, Cohen B, Rivera-Stein MA, Rosen W, Gorman JM et al. Signs of central nervous system dysfunction in obsessive-compulsive disorder. Archives of General Psychiatry. 1990;47(1):27-32.
Hollander, Eric ; Schifftnan, Erica ; Cohen, Barry ; Rivera-Stein, Maria A. ; Rosen, Wilma ; Gorman, Jack M. ; Fyer, Abby J. ; Papp, Laszlo ; Liebowitz, Michael R. / Signs of central nervous system dysfunction in obsessive-compulsive disorder. In: Archives of General Psychiatry. 1990 ; Vol. 47, No. 1. pp. 27-32.
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