Significance of preoperative radiographic pancreatic density in predicting pancreatic fistula after surgery for pancreatic neuroendocrine tumors

Yasmine Assadipour, Saïd C. Azoury, Nicholas N. Schaub, Young Hong, Robert Eil, Suzanne M. Inchauste, Seth M. Steinberg, Aradhana M. Venkatesan, Steven K. Libutti, Marybeth S. Hughes

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Postoperative pancreatic fistula remains the most severe and worrisome complication after surgery. Predictive preoperative assessment remains challenging. The authors examine the role of pancreatic computed tomography density in predicting postoperative pancreatic fistula after surgery for pancreatic neuroendocrine tumors. Methods: A single institutional retrospective review of pancreatic surgery for neuroendocrine tumors between 1998 and 2010 was conducted. Preoperative contrast-enhanced computed tomography scans were reviewed, with mean region of interest measurements of pancreatic parenchymal density obtained from 10-mm thick axial computed tomography images. Results: A total of 119 patients were identified: 59 with enucleations and 60 with resections. Decreased preoperative pancreatic density was significantly associated with an increased grade of postoperative pancreatic fistula (P <.01). Subgroup analyses revealed that decreased gland density was associated with increased grade of postoperative pancreatic fistula in the resection (P <.01) but not in the enucleation group (P = .34). Conclusions: A significant association between postoperative pancreatic fistula grade and preoperative pancreatic computed tomography density is observed in patients undergoing resection for pancreatic neuroendocrine tumors.

Original languageEnglish (US)
JournalAmerican Journal of Surgery
DOIs
StateAccepted/In press - Jan 22 2015

Fingerprint

Pancreatic Fistula
Neuroendocrine Tumors
Tomography

Keywords

  • Neuroendocrine tumors
  • Pancreatic enucleation
  • Pancreatic fistula
  • Pancreatic resection
  • Pancreaticoduodenectomy

ASJC Scopus subject areas

  • Surgery

Cite this

Significance of preoperative radiographic pancreatic density in predicting pancreatic fistula after surgery for pancreatic neuroendocrine tumors. / Assadipour, Yasmine; Azoury, Saïd C.; Schaub, Nicholas N.; Hong, Young; Eil, Robert; Inchauste, Suzanne M.; Steinberg, Seth M.; Venkatesan, Aradhana M.; Libutti, Steven K.; Hughes, Marybeth S.

In: American Journal of Surgery, 22.01.2015.

Research output: Contribution to journalArticle

Assadipour, Yasmine ; Azoury, Saïd C. ; Schaub, Nicholas N. ; Hong, Young ; Eil, Robert ; Inchauste, Suzanne M. ; Steinberg, Seth M. ; Venkatesan, Aradhana M. ; Libutti, Steven K. ; Hughes, Marybeth S. / Significance of preoperative radiographic pancreatic density in predicting pancreatic fistula after surgery for pancreatic neuroendocrine tumors. In: American Journal of Surgery. 2015.
@article{441ffd4040d041669887f6e0b37e1442,
title = "Significance of preoperative radiographic pancreatic density in predicting pancreatic fistula after surgery for pancreatic neuroendocrine tumors",
abstract = "Background: Postoperative pancreatic fistula remains the most severe and worrisome complication after surgery. Predictive preoperative assessment remains challenging. The authors examine the role of pancreatic computed tomography density in predicting postoperative pancreatic fistula after surgery for pancreatic neuroendocrine tumors. Methods: A single institutional retrospective review of pancreatic surgery for neuroendocrine tumors between 1998 and 2010 was conducted. Preoperative contrast-enhanced computed tomography scans were reviewed, with mean region of interest measurements of pancreatic parenchymal density obtained from 10-mm thick axial computed tomography images. Results: A total of 119 patients were identified: 59 with enucleations and 60 with resections. Decreased preoperative pancreatic density was significantly associated with an increased grade of postoperative pancreatic fistula (P <.01). Subgroup analyses revealed that decreased gland density was associated with increased grade of postoperative pancreatic fistula in the resection (P <.01) but not in the enucleation group (P = .34). Conclusions: A significant association between postoperative pancreatic fistula grade and preoperative pancreatic computed tomography density is observed in patients undergoing resection for pancreatic neuroendocrine tumors.",
keywords = "Neuroendocrine tumors, Pancreatic enucleation, Pancreatic fistula, Pancreatic resection, Pancreaticoduodenectomy",
author = "Yasmine Assadipour and Azoury, {Sa{\"i}d C.} and Schaub, {Nicholas N.} and Young Hong and Robert Eil and Inchauste, {Suzanne M.} and Steinberg, {Seth M.} and Venkatesan, {Aradhana M.} and Libutti, {Steven K.} and Hughes, {Marybeth S.}",
year = "2015",
month = "1",
day = "22",
doi = "10.1016/j.amjsurg.2015.07.031",
language = "English (US)",
journal = "American Journal of Surgery",
issn = "0002-9610",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Significance of preoperative radiographic pancreatic density in predicting pancreatic fistula after surgery for pancreatic neuroendocrine tumors

AU - Assadipour, Yasmine

AU - Azoury, Saïd C.

AU - Schaub, Nicholas N.

AU - Hong, Young

AU - Eil, Robert

AU - Inchauste, Suzanne M.

AU - Steinberg, Seth M.

AU - Venkatesan, Aradhana M.

AU - Libutti, Steven K.

AU - Hughes, Marybeth S.

PY - 2015/1/22

Y1 - 2015/1/22

N2 - Background: Postoperative pancreatic fistula remains the most severe and worrisome complication after surgery. Predictive preoperative assessment remains challenging. The authors examine the role of pancreatic computed tomography density in predicting postoperative pancreatic fistula after surgery for pancreatic neuroendocrine tumors. Methods: A single institutional retrospective review of pancreatic surgery for neuroendocrine tumors between 1998 and 2010 was conducted. Preoperative contrast-enhanced computed tomography scans were reviewed, with mean region of interest measurements of pancreatic parenchymal density obtained from 10-mm thick axial computed tomography images. Results: A total of 119 patients were identified: 59 with enucleations and 60 with resections. Decreased preoperative pancreatic density was significantly associated with an increased grade of postoperative pancreatic fistula (P <.01). Subgroup analyses revealed that decreased gland density was associated with increased grade of postoperative pancreatic fistula in the resection (P <.01) but not in the enucleation group (P = .34). Conclusions: A significant association between postoperative pancreatic fistula grade and preoperative pancreatic computed tomography density is observed in patients undergoing resection for pancreatic neuroendocrine tumors.

AB - Background: Postoperative pancreatic fistula remains the most severe and worrisome complication after surgery. Predictive preoperative assessment remains challenging. The authors examine the role of pancreatic computed tomography density in predicting postoperative pancreatic fistula after surgery for pancreatic neuroendocrine tumors. Methods: A single institutional retrospective review of pancreatic surgery for neuroendocrine tumors between 1998 and 2010 was conducted. Preoperative contrast-enhanced computed tomography scans were reviewed, with mean region of interest measurements of pancreatic parenchymal density obtained from 10-mm thick axial computed tomography images. Results: A total of 119 patients were identified: 59 with enucleations and 60 with resections. Decreased preoperative pancreatic density was significantly associated with an increased grade of postoperative pancreatic fistula (P <.01). Subgroup analyses revealed that decreased gland density was associated with increased grade of postoperative pancreatic fistula in the resection (P <.01) but not in the enucleation group (P = .34). Conclusions: A significant association between postoperative pancreatic fistula grade and preoperative pancreatic computed tomography density is observed in patients undergoing resection for pancreatic neuroendocrine tumors.

KW - Neuroendocrine tumors

KW - Pancreatic enucleation

KW - Pancreatic fistula

KW - Pancreatic resection

KW - Pancreaticoduodenectomy

UR - http://www.scopus.com/inward/record.url?scp=84953432644&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84953432644&partnerID=8YFLogxK

U2 - 10.1016/j.amjsurg.2015.07.031

DO - 10.1016/j.amjsurg.2015.07.031

M3 - Article

JO - American Journal of Surgery

JF - American Journal of Surgery

SN - 0002-9610

ER -