Significance of epicardial and intrathoracic adipose tissue volume among type 1 diabetes patients in the DCCT/EDIC

A pilot study

DCCT/EDIC Research Group

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Introduction: Type 1 diabetes (T1DM) patients are at increased risk of coronary artery disease (CAD). This pilot study sought to evaluate the relationship between epicardial adipose tissue (EAT) and intra-thoracic adipose tissue (IAT) volumes and cardio-metabolic risk factors in T1DM. Method: EAT/IAT volumes in 100 patients, underwent non-contrast cardiac computed tomography in the Diabetes Control and Complications Trial /Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study were measured by a certified reader. Fat was defined as pixels' density of -30 to -190 Hounsfield Unit. The associations were assessed using-Pearson partial correlation and linear regression models adjusted for gender and age with inverse probability sample weighting. Results: The weighted mean age was 43 years (range 32-57) and 53% were male. Adjusted for gender, Pearson correlation analysis showed a significant correlation between age and EAT/IAT volumes (both p<0.001). After adjusting for gender and age, participants with greater BMI, higher waist to hip ratio (WTH), higher weighted HbA1c, elevated triglyceride level, and a history of albumin excretion rate of equal or greater than 300 mg/d (AER≥300) or end stage renal disease (ESRD) had significantly larger EAT/IAT volumes. Conclusion: T1DM patients with greater BMI, WTH ratio, weighted HbA1c level, triglyceride level and AER≥300/ESRD had significantly larger EAT/IAT volumes. Larger sample size studies are recommended to evaluate independency.

Original languageEnglish (US)
Article numbere0159958
JournalPLoS One
Volume11
Issue number7
DOIs
StatePublished - Jul 1 2016

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Epidemiology
insulin-dependent diabetes mellitus
Diabetes Complications
Medical problems
Type 1 Diabetes Mellitus
adipose tissue
diabetes
Adipose Tissue
epidemiology
Tissue
chest
Thorax
waist-to-hip ratio
glycohemoglobin
Waist-Hip Ratio
kidney diseases
Chronic Kidney Failure
gender
Linear Models
Triglycerides

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Significance of epicardial and intrathoracic adipose tissue volume among type 1 diabetes patients in the DCCT/EDIC : A pilot study. / DCCT/EDIC Research Group.

In: PLoS One, Vol. 11, No. 7, e0159958, 01.07.2016.

Research output: Contribution to journalArticle

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title = "Significance of epicardial and intrathoracic adipose tissue volume among type 1 diabetes patients in the DCCT/EDIC: A pilot study",
abstract = "Introduction: Type 1 diabetes (T1DM) patients are at increased risk of coronary artery disease (CAD). This pilot study sought to evaluate the relationship between epicardial adipose tissue (EAT) and intra-thoracic adipose tissue (IAT) volumes and cardio-metabolic risk factors in T1DM. Method: EAT/IAT volumes in 100 patients, underwent non-contrast cardiac computed tomography in the Diabetes Control and Complications Trial /Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study were measured by a certified reader. Fat was defined as pixels' density of -30 to -190 Hounsfield Unit. The associations were assessed using-Pearson partial correlation and linear regression models adjusted for gender and age with inverse probability sample weighting. Results: The weighted mean age was 43 years (range 32-57) and 53{\%} were male. Adjusted for gender, Pearson correlation analysis showed a significant correlation between age and EAT/IAT volumes (both p<0.001). After adjusting for gender and age, participants with greater BMI, higher waist to hip ratio (WTH), higher weighted HbA1c, elevated triglyceride level, and a history of albumin excretion rate of equal or greater than 300 mg/d (AER≥300) or end stage renal disease (ESRD) had significantly larger EAT/IAT volumes. Conclusion: T1DM patients with greater BMI, WTH ratio, weighted HbA1c level, triglyceride level and AER≥300/ESRD had significantly larger EAT/IAT volumes. Larger sample size studies are recommended to evaluate independency.",
author = "{DCCT/EDIC Research Group} and Sirous Darabian and Backlund, {Jye Yu C} and Cleary, {Patricia A.} and Nasim Sheidaee and Ionut Bebu and Lachin, {John M.} and Budoff, {Matthew J.} and Nathan, {D. M.} and B. Zinman and O. Crofford and S. Genuth and J. Brown-Friday and Crandall, {Jill P.} and H. Engel and S. Engel and H. Martinez and M. Phillips and M. Reid and Harry Shamoon and J. Sheindlin and R. Gubitosi-Klug and L. Mayer and S. Pendegast and H. Zegarra and D. Miller and L. Singerman and S. Smith-Brewer and M. Novak and J. Quin and Saul Genuth and M. Palmert and E. Brown and J. McConnell and P. Pugsley and P. Crawford and W. Dahms and D. Brillon and Lackaye, {M. E.} and S. Kiss and R. Chan and A. Orlin and M. Rubin and V. Reppucci and T. Lee and M. Heinemann and S. Chang and B. Levy and L. Jovanovic and M. Richardson and B. Bosco",
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T1 - Significance of epicardial and intrathoracic adipose tissue volume among type 1 diabetes patients in the DCCT/EDIC

T2 - A pilot study

AU - DCCT/EDIC Research Group

AU - Darabian, Sirous

AU - Backlund, Jye Yu C

AU - Cleary, Patricia A.

AU - Sheidaee, Nasim

AU - Bebu, Ionut

AU - Lachin, John M.

AU - Budoff, Matthew J.

AU - Nathan, D. M.

AU - Zinman, B.

AU - Crofford, O.

AU - Genuth, S.

AU - Brown-Friday, J.

AU - Crandall, Jill P.

AU - Engel, H.

AU - Engel, S.

AU - Martinez, H.

AU - Phillips, M.

AU - Reid, M.

AU - Shamoon, Harry

AU - Sheindlin, J.

AU - Gubitosi-Klug, R.

AU - Mayer, L.

AU - Pendegast, S.

AU - Zegarra, H.

AU - Miller, D.

AU - Singerman, L.

AU - Smith-Brewer, S.

AU - Novak, M.

AU - Quin, J.

AU - Genuth, Saul

AU - Palmert, M.

AU - Brown, E.

AU - McConnell, J.

AU - Pugsley, P.

AU - Crawford, P.

AU - Dahms, W.

AU - Brillon, D.

AU - Lackaye, M. E.

AU - Kiss, S.

AU - Chan, R.

AU - Orlin, A.

AU - Rubin, M.

AU - Reppucci, V.

AU - Lee, T.

AU - Heinemann, M.

AU - Chang, S.

AU - Levy, B.

AU - Jovanovic, L.

AU - Richardson, M.

AU - Bosco, B.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Introduction: Type 1 diabetes (T1DM) patients are at increased risk of coronary artery disease (CAD). This pilot study sought to evaluate the relationship between epicardial adipose tissue (EAT) and intra-thoracic adipose tissue (IAT) volumes and cardio-metabolic risk factors in T1DM. Method: EAT/IAT volumes in 100 patients, underwent non-contrast cardiac computed tomography in the Diabetes Control and Complications Trial /Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study were measured by a certified reader. Fat was defined as pixels' density of -30 to -190 Hounsfield Unit. The associations were assessed using-Pearson partial correlation and linear regression models adjusted for gender and age with inverse probability sample weighting. Results: The weighted mean age was 43 years (range 32-57) and 53% were male. Adjusted for gender, Pearson correlation analysis showed a significant correlation between age and EAT/IAT volumes (both p<0.001). After adjusting for gender and age, participants with greater BMI, higher waist to hip ratio (WTH), higher weighted HbA1c, elevated triglyceride level, and a history of albumin excretion rate of equal or greater than 300 mg/d (AER≥300) or end stage renal disease (ESRD) had significantly larger EAT/IAT volumes. Conclusion: T1DM patients with greater BMI, WTH ratio, weighted HbA1c level, triglyceride level and AER≥300/ESRD had significantly larger EAT/IAT volumes. Larger sample size studies are recommended to evaluate independency.

AB - Introduction: Type 1 diabetes (T1DM) patients are at increased risk of coronary artery disease (CAD). This pilot study sought to evaluate the relationship between epicardial adipose tissue (EAT) and intra-thoracic adipose tissue (IAT) volumes and cardio-metabolic risk factors in T1DM. Method: EAT/IAT volumes in 100 patients, underwent non-contrast cardiac computed tomography in the Diabetes Control and Complications Trial /Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study were measured by a certified reader. Fat was defined as pixels' density of -30 to -190 Hounsfield Unit. The associations were assessed using-Pearson partial correlation and linear regression models adjusted for gender and age with inverse probability sample weighting. Results: The weighted mean age was 43 years (range 32-57) and 53% were male. Adjusted for gender, Pearson correlation analysis showed a significant correlation between age and EAT/IAT volumes (both p<0.001). After adjusting for gender and age, participants with greater BMI, higher waist to hip ratio (WTH), higher weighted HbA1c, elevated triglyceride level, and a history of albumin excretion rate of equal or greater than 300 mg/d (AER≥300) or end stage renal disease (ESRD) had significantly larger EAT/IAT volumes. Conclusion: T1DM patients with greater BMI, WTH ratio, weighted HbA1c level, triglyceride level and AER≥300/ESRD had significantly larger EAT/IAT volumes. Larger sample size studies are recommended to evaluate independency.

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U2 - 10.1371/journal.pone.0159958

DO - 10.1371/journal.pone.0159958

M3 - Article

VL - 11

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 7

M1 - e0159958

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