Signals, synapses, and synthesis: How new proteins control plasticity

R. Suzanne Zukin, Joel D. Richter, Claudia Bagni

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Localization of mRNAs to dendrites and local protein synthesis afford spatial and temporal regulation of gene expression and endow synapses with the capacity to autonomously alter their structure and function. Emerging evidence indicates that RNA binding proteins, ribosomes, translation factors and mRNAs encoding proteins critical to synaptic structure and function localize to neuronal processes. RNAs are transported into dendrites in a translationally quiescent state where they are activated by synaptic stimuli. Two RNA binding proteins that regulate dendritic RNA delivery and translational repression are cytoplasmic polyadenylation element binding protein and fragile X mental retardation protein (FMRP). The fragile X syndrome (FXS) is the most common known genetic cause of autism and is characterized by the loss of FMRP. Hallmark features of the FXS include dysregulation of spine morphogenesis and exaggerated metabotropic glutamate receptor-dependent long term depression, a cellular substrate of learning and memory. Current research focuses on mechanisms whereby mRNAs are transported in a translationally repressed state from soma to distal process and are activated at synaptic sites in response to synaptic signals.

Original languageEnglish (US)
Article number14
JournalFrontiers in Neural Circuits
Volume3
Issue numberOCT
DOIs
StatePublished - Oct 7 2009

Fingerprint

Fragile X Mental Retardation Protein
Synapses
Fragile X Syndrome
RNA-Binding Proteins
Dendrites
Messenger RNA
RNA
Polyadenylation
Metabotropic Glutamate Receptors
Proteins
Gene Expression Regulation
Protein Biosynthesis
Carisoprodol
Autistic Disorder
Ribosomes
Morphogenesis
Carrier Proteins
Spine
Learning
Depression

Keywords

  • CPEB
  • Cytoplasmic polyadenylation
  • FMRP
  • Fragile X syndrome
  • Synaptic plasticity
  • Synaptic signaling
  • Translational control

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Cellular and Molecular Neuroscience
  • Sensory Systems
  • Cognitive Neuroscience

Cite this

Signals, synapses, and synthesis : How new proteins control plasticity. / Zukin, R. Suzanne; Richter, Joel D.; Bagni, Claudia.

In: Frontiers in Neural Circuits, Vol. 3, No. OCT, 14, 07.10.2009.

Research output: Contribution to journalArticle

@article{a41416cbd2f340a9a243389a64ec9e87,
title = "Signals, synapses, and synthesis: How new proteins control plasticity",
abstract = "Localization of mRNAs to dendrites and local protein synthesis afford spatial and temporal regulation of gene expression and endow synapses with the capacity to autonomously alter their structure and function. Emerging evidence indicates that RNA binding proteins, ribosomes, translation factors and mRNAs encoding proteins critical to synaptic structure and function localize to neuronal processes. RNAs are transported into dendrites in a translationally quiescent state where they are activated by synaptic stimuli. Two RNA binding proteins that regulate dendritic RNA delivery and translational repression are cytoplasmic polyadenylation element binding protein and fragile X mental retardation protein (FMRP). The fragile X syndrome (FXS) is the most common known genetic cause of autism and is characterized by the loss of FMRP. Hallmark features of the FXS include dysregulation of spine morphogenesis and exaggerated metabotropic glutamate receptor-dependent long term depression, a cellular substrate of learning and memory. Current research focuses on mechanisms whereby mRNAs are transported in a translationally repressed state from soma to distal process and are activated at synaptic sites in response to synaptic signals.",
keywords = "CPEB, Cytoplasmic polyadenylation, FMRP, Fragile X syndrome, Synaptic plasticity, Synaptic signaling, Translational control",
author = "Zukin, {R. Suzanne} and Richter, {Joel D.} and Claudia Bagni",
year = "2009",
month = "10",
day = "7",
doi = "10.3389/neuro.04.014.2009",
language = "English (US)",
volume = "3",
journal = "Frontiers in Neural Circuits",
issn = "1662-5110",
publisher = "Frontiers Research Foundation",
number = "OCT",

}

TY - JOUR

T1 - Signals, synapses, and synthesis

T2 - How new proteins control plasticity

AU - Zukin, R. Suzanne

AU - Richter, Joel D.

AU - Bagni, Claudia

PY - 2009/10/7

Y1 - 2009/10/7

N2 - Localization of mRNAs to dendrites and local protein synthesis afford spatial and temporal regulation of gene expression and endow synapses with the capacity to autonomously alter their structure and function. Emerging evidence indicates that RNA binding proteins, ribosomes, translation factors and mRNAs encoding proteins critical to synaptic structure and function localize to neuronal processes. RNAs are transported into dendrites in a translationally quiescent state where they are activated by synaptic stimuli. Two RNA binding proteins that regulate dendritic RNA delivery and translational repression are cytoplasmic polyadenylation element binding protein and fragile X mental retardation protein (FMRP). The fragile X syndrome (FXS) is the most common known genetic cause of autism and is characterized by the loss of FMRP. Hallmark features of the FXS include dysregulation of spine morphogenesis and exaggerated metabotropic glutamate receptor-dependent long term depression, a cellular substrate of learning and memory. Current research focuses on mechanisms whereby mRNAs are transported in a translationally repressed state from soma to distal process and are activated at synaptic sites in response to synaptic signals.

AB - Localization of mRNAs to dendrites and local protein synthesis afford spatial and temporal regulation of gene expression and endow synapses with the capacity to autonomously alter their structure and function. Emerging evidence indicates that RNA binding proteins, ribosomes, translation factors and mRNAs encoding proteins critical to synaptic structure and function localize to neuronal processes. RNAs are transported into dendrites in a translationally quiescent state where they are activated by synaptic stimuli. Two RNA binding proteins that regulate dendritic RNA delivery and translational repression are cytoplasmic polyadenylation element binding protein and fragile X mental retardation protein (FMRP). The fragile X syndrome (FXS) is the most common known genetic cause of autism and is characterized by the loss of FMRP. Hallmark features of the FXS include dysregulation of spine morphogenesis and exaggerated metabotropic glutamate receptor-dependent long term depression, a cellular substrate of learning and memory. Current research focuses on mechanisms whereby mRNAs are transported in a translationally repressed state from soma to distal process and are activated at synaptic sites in response to synaptic signals.

KW - CPEB

KW - Cytoplasmic polyadenylation

KW - FMRP

KW - Fragile X syndrome

KW - Synaptic plasticity

KW - Synaptic signaling

KW - Translational control

UR - http://www.scopus.com/inward/record.url?scp=77952430888&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952430888&partnerID=8YFLogxK

U2 - 10.3389/neuro.04.014.2009

DO - 10.3389/neuro.04.014.2009

M3 - Article

AN - SCOPUS:77952430888

VL - 3

JO - Frontiers in Neural Circuits

JF - Frontiers in Neural Circuits

SN - 1662-5110

IS - OCT

M1 - 14

ER -