Signaling to and from the RNA Polymerase III Transcription and Processing Machinery

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

RNA polymerase (Pol) III has a specialized role in transcribing the most abundant RNAs in eukaryotic cells, transfer RNAs (tRNAs), along with other ubiquitous small noncoding RNAs, many of which have functions related to the ribosome and protein synthesis. The high energetic cost of producing these RNAs and their central role in protein synthesis underlie the robust regulation of Pol III transcription in response to nutrients and stress by growth regulatory pathways. Downstream of Pol III, signaling impacts posttranscriptional processes affecting tRNA function in translation and tRNA cleavage into smaller fragments that are increasingly attributed with novel cellular activities. In this review, we consider how nutrients and stress control Pol III transcription via its factors and its negative regulator, Maf1. We highlight recent work showing that the composition of the tRNA population and the function of individual tRNAs is dynamically controlled and that unrestrained Pol III transcription can reprogram central metabolic pathways.

Original languageEnglish (US)
Pages (from-to)75-100
Number of pages26
JournalAnnual Review of Biochemistry
Volume87
DOIs
StatePublished - Jun 20 2018

Fingerprint

RNA Polymerase III
Transcription
Transfer RNA
Machinery
Processing
Nutrients
RNA Cleavage
RNA
Small Untranslated RNA
Food
Eukaryotic Cells
Metabolic Networks and Pathways
Ribosomes
Proteins
Costs and Cost Analysis
Growth
Chemical analysis
Population
Costs

Keywords

  • metabolism
  • regulation
  • RNA polymerase III
  • signaling
  • transcription
  • tRNA fragments
  • tRNA modification

ASJC Scopus subject areas

  • Biochemistry

Cite this

Signaling to and from the RNA Polymerase III Transcription and Processing Machinery. / Willis, Ian M.; Moir, Robyn D.

In: Annual Review of Biochemistry, Vol. 87, 20.06.2018, p. 75-100.

Research output: Contribution to journalReview article

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