Signaling pathways in reactive astrocytes, a genetic perspective

Wenfei Kang, Jean M. Hebert

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Reactive astrocytes are associated with a vast array of central nervous system (CNS) pathologies. The activation of astrocytes is characterized by changes in their molecular and morphological features, and depending on the type of damage can also be accompanied by inflammatory responses, neuronal damage, and in severe cases, scar formation. Although reactive astrogliosis is the normal physiological response essential for containing damage, it can also have detrimental effects on neuronal survival and axon regeneration, particularly in neurodegenerative diseases. It is believed that progressive changes in astrocytes as they become reactive are finely regulated by complex intercellular and intracellular signaling mechanisms. However, these have yet to be sorted out. Much has been learned from gain-of-function approaches in vivo and culture paradigms, but in most cases, loss-of-function genetic studies, which are a critical complementary approach, have been lacking. Understanding which signaling pathways are required to control different aspects of astrogliosis will be necessary for designing therapeutic strategies to improve their beneficial effects and limit their detrimental ones in CNS pathologies. In this article, we review recent advances in the mechanisms underlying the regulation of aspects of astrogliosis, with the main focus on the signaling pathways that have been studied using loss-of-function genetic mouse models.

Original languageEnglish (US)
Pages (from-to)147-154
Number of pages8
JournalMolecular Neurobiology
Volume43
Issue number3
DOIs
StatePublished - Jun 2011

Fingerprint

Astrocytes
Central Nervous System
Pathology
Genetic Models
Neurodegenerative Diseases
Cicatrix
Axons
Regeneration
Therapeutics

Keywords

  • Astrogliosis
  • Genetics
  • Gliosis
  • Reactive gliosis

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Signaling pathways in reactive astrocytes, a genetic perspective. / Kang, Wenfei; Hebert, Jean M.

In: Molecular Neurobiology, Vol. 43, No. 3, 06.2011, p. 147-154.

Research output: Contribution to journalArticle

@article{e60e16de9ee84d2fbc637e29ffb02d75,
title = "Signaling pathways in reactive astrocytes, a genetic perspective",
abstract = "Reactive astrocytes are associated with a vast array of central nervous system (CNS) pathologies. The activation of astrocytes is characterized by changes in their molecular and morphological features, and depending on the type of damage can also be accompanied by inflammatory responses, neuronal damage, and in severe cases, scar formation. Although reactive astrogliosis is the normal physiological response essential for containing damage, it can also have detrimental effects on neuronal survival and axon regeneration, particularly in neurodegenerative diseases. It is believed that progressive changes in astrocytes as they become reactive are finely regulated by complex intercellular and intracellular signaling mechanisms. However, these have yet to be sorted out. Much has been learned from gain-of-function approaches in vivo and culture paradigms, but in most cases, loss-of-function genetic studies, which are a critical complementary approach, have been lacking. Understanding which signaling pathways are required to control different aspects of astrogliosis will be necessary for designing therapeutic strategies to improve their beneficial effects and limit their detrimental ones in CNS pathologies. In this article, we review recent advances in the mechanisms underlying the regulation of aspects of astrogliosis, with the main focus on the signaling pathways that have been studied using loss-of-function genetic mouse models.",
keywords = "Astrogliosis, Genetics, Gliosis, Reactive gliosis",
author = "Wenfei Kang and Hebert, {Jean M.}",
year = "2011",
month = "6",
doi = "10.1007/s12035-011-8163-7",
language = "English (US)",
volume = "43",
pages = "147--154",
journal = "Molecular Neurobiology",
issn = "0893-7648",
publisher = "Humana Press",
number = "3",

}

TY - JOUR

T1 - Signaling pathways in reactive astrocytes, a genetic perspective

AU - Kang, Wenfei

AU - Hebert, Jean M.

PY - 2011/6

Y1 - 2011/6

N2 - Reactive astrocytes are associated with a vast array of central nervous system (CNS) pathologies. The activation of astrocytes is characterized by changes in their molecular and morphological features, and depending on the type of damage can also be accompanied by inflammatory responses, neuronal damage, and in severe cases, scar formation. Although reactive astrogliosis is the normal physiological response essential for containing damage, it can also have detrimental effects on neuronal survival and axon regeneration, particularly in neurodegenerative diseases. It is believed that progressive changes in astrocytes as they become reactive are finely regulated by complex intercellular and intracellular signaling mechanisms. However, these have yet to be sorted out. Much has been learned from gain-of-function approaches in vivo and culture paradigms, but in most cases, loss-of-function genetic studies, which are a critical complementary approach, have been lacking. Understanding which signaling pathways are required to control different aspects of astrogliosis will be necessary for designing therapeutic strategies to improve their beneficial effects and limit their detrimental ones in CNS pathologies. In this article, we review recent advances in the mechanisms underlying the regulation of aspects of astrogliosis, with the main focus on the signaling pathways that have been studied using loss-of-function genetic mouse models.

AB - Reactive astrocytes are associated with a vast array of central nervous system (CNS) pathologies. The activation of astrocytes is characterized by changes in their molecular and morphological features, and depending on the type of damage can also be accompanied by inflammatory responses, neuronal damage, and in severe cases, scar formation. Although reactive astrogliosis is the normal physiological response essential for containing damage, it can also have detrimental effects on neuronal survival and axon regeneration, particularly in neurodegenerative diseases. It is believed that progressive changes in astrocytes as they become reactive are finely regulated by complex intercellular and intracellular signaling mechanisms. However, these have yet to be sorted out. Much has been learned from gain-of-function approaches in vivo and culture paradigms, but in most cases, loss-of-function genetic studies, which are a critical complementary approach, have been lacking. Understanding which signaling pathways are required to control different aspects of astrogliosis will be necessary for designing therapeutic strategies to improve their beneficial effects and limit their detrimental ones in CNS pathologies. In this article, we review recent advances in the mechanisms underlying the regulation of aspects of astrogliosis, with the main focus on the signaling pathways that have been studied using loss-of-function genetic mouse models.

KW - Astrogliosis

KW - Genetics

KW - Gliosis

KW - Reactive gliosis

UR - http://www.scopus.com/inward/record.url?scp=79958259743&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958259743&partnerID=8YFLogxK

U2 - 10.1007/s12035-011-8163-7

DO - 10.1007/s12035-011-8163-7

M3 - Article

C2 - 21234816

AN - SCOPUS:79958259743

VL - 43

SP - 147

EP - 154

JO - Molecular Neurobiology

JF - Molecular Neurobiology

SN - 0893-7648

IS - 3

ER -