Signaling Pathways in Leukemic Stem Cells

Lindsay M. Gurska, Kristina Ames, Kira Gritsman

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs) utilize many of the same signaling pathways for their maintenance and survival. In this review, we will focus on several signaling pathways whose roles have been extensively studied in both HSCs and LSCs. Our main focus will be on the PI3K/AKT/mTOR pathway and several of its regulators and downstream effectors. We will also discuss several other signaling pathways of particular importance in LSCs, including the WNT/β-catenin pathway, the NOTCH pathway, and the TGFβ pathway. For each of these pathways, we will emphasize differences in how these pathways operate in LSCs, compared to their function in HSCs, to highlight opportunities for the specific therapeutic targeting of LSCs. We will also highlight areas of crosstalk between multiple signaling pathways that may affect LSC function.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages1-39
Number of pages39
DOIs
StatePublished - Jan 1 2019

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1143
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Akt
  • FOXO
  • Hematopoietic stem cell
  • Leukemic stem cell
  • NOTCH
  • PI3K
  • Signaling
  • TGFβ
  • WNT
  • mTOR
  • β-Catenin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Gurska, L. M., Ames, K., & Gritsman, K. (2019). Signaling Pathways in Leukemic Stem Cells. In Advances in Experimental Medicine and Biology (pp. 1-39). (Advances in Experimental Medicine and Biology; Vol. 1143). Springer New York LLC. https://doi.org/10.1007/978-981-13-7342-8_1