@inbook{24d047f76ce549c2a56293dc21b07093,
title = "Signaling Pathways in Leukemic Stem Cells",
abstract = "Hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs) utilize many of the same signaling pathways for their maintenance and survival. In this review, we will focus on several signaling pathways whose roles have been extensively studied in both HSCs and LSCs. Our main focus will be on the PI3K/AKT/mTOR pathway and several of its regulators and downstream effectors. We will also discuss several other signaling pathways of particular importance in LSCs, including the WNT/{\^I}²-catenin pathway, the NOTCH pathway, and the TGF{\^I}² pathway. For each of these pathways, we will emphasize differences in how these pathways operate in LSCs, compared to their function in HSCs, to highlight opportunities for the specific therapeutic targeting of LSCs. We will also highlight areas of crosstalk between multiple signaling pathways that may affect LSC function.",
keywords = "Akt, FOXO, Hematopoietic stem cell, Leukemic stem cell, NOTCH, PI3K, Signaling, TGF{\^I}², WNT, mTOR, {\^I}²-Catenin",
author = "Gurska, {Lindsay M.} and Kristina Ames and Kira Gritsman",
note = "Funding Information: We thank all members of the Gritsman lab for helpful discussions. We apolo-gize to any authors whose work was not cited due to space limitations. This work was supported by the NIH/NCI R01 #R01CA196973 (KG), the American Society of Hematology (KG), the V Foundation for Cancer Research (KG), the Sinsheimer Foundation (KG), the Training Program in Cellular and Molecular Biology and Genetics at Albert Einstein College of Medicine #5T32GM007491-44 (LG), and the IRACDA-BETTR Postdoctoral Training Grant at Albert Einstein College of Medicine #2K12GM102779 (KA).",
year = "2019",
doi = "10.1007/978-981-13-7342-8_1",
language = "English (US)",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer New York LLC",
pages = "1--39",
booktitle = "Advances in Experimental Medicine and Biology",
}