Signal Transduction, Ageing and Disease

Lei Zhang, Matthew J. Yousefzadeh, Yousin Suh, Laura J. Niedernhofer, Paul D. Robbins

Research output: Contribution to journalArticle

Abstract

Ageing is defined by the loss of functional reserve over time, leading to a decreased tissue homeostasis and increased age-related pathology. The accumulation of damage including DNA damage contributes to driving cell signaling pathways that, in turn, can drive different cell fates, including senescence and apoptosis, as well as mitochondrial dysfunction and inflammation. In addition, the accumulation of cell autonomous damage with time also drives ageing through non-cell autonomous pathways by modulation of signaling pathways. Interestingly, genetic and pharmacologic analysis of factors able to modulate lifespan and healthspan in model organisms and even humans have identified several key signaling pathways including IGF-1, NF-κB, FOXO3, mTOR, Nrf-2 and sirtuins. This review will discuss the roles of several of these key signaling pathways, in particular NF-κB and Nrf2, in modulating ageing and age-related diseases.

Original languageEnglish (US)
Pages (from-to)227-247
Number of pages21
JournalSub-cellular biochemistry
Volume91
DOIs
StatePublished - Jan 1 2019

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Signal transduction
Signal Transduction
Aging of materials
Tissue homeostasis
Sirtuins
Cell signaling
Pathology
Insulin-Like Growth Factor I
DNA Damage
Statistical Factor Analysis
Homeostasis
Cells
Modulation
Apoptosis
Inflammation
DNA

Keywords

  • Age-related disease
  • Apoptosis
  • Inflammation
  • NF-κB Nrf2
  • Senescence
  • Signaling pathways
  • Sirtuins

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology
  • Cancer Research

Cite this

Zhang, L., Yousefzadeh, M. J., Suh, Y., Niedernhofer, L. J., & Robbins, P. D. (2019). Signal Transduction, Ageing and Disease. Sub-cellular biochemistry, 91, 227-247. https://doi.org/10.1007/978-981-13-3681-2_9

Signal Transduction, Ageing and Disease. / Zhang, Lei; Yousefzadeh, Matthew J.; Suh, Yousin; Niedernhofer, Laura J.; Robbins, Paul D.

In: Sub-cellular biochemistry, Vol. 91, 01.01.2019, p. 227-247.

Research output: Contribution to journalArticle

Zhang, L, Yousefzadeh, MJ, Suh, Y, Niedernhofer, LJ & Robbins, PD 2019, 'Signal Transduction, Ageing and Disease', Sub-cellular biochemistry, vol. 91, pp. 227-247. https://doi.org/10.1007/978-981-13-3681-2_9
Zhang L, Yousefzadeh MJ, Suh Y, Niedernhofer LJ, Robbins PD. Signal Transduction, Ageing and Disease. Sub-cellular biochemistry. 2019 Jan 1;91:227-247. https://doi.org/10.1007/978-981-13-3681-2_9
Zhang, Lei ; Yousefzadeh, Matthew J. ; Suh, Yousin ; Niedernhofer, Laura J. ; Robbins, Paul D. / Signal Transduction, Ageing and Disease. In: Sub-cellular biochemistry. 2019 ; Vol. 91. pp. 227-247.
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