The side chain conformations of several residues of oxytocin and [8-arginine]vasopressin are compared by using measurements of the circumjacent vicinal couplings of 1Hα, 13C', and 15N’ to β protons and stereospecific β deuteration in series of 18 specifically designed and synthesized isotopic isomers. The conformation(s) of half-cystyls-1 and -6 and tyrosyl-2 is (are) markedly similar when comparing the two peptides, and other residues show only small differences. Conformational classes of side chain are identified. It is concluded that most of the side chain conformations are largely uninfluenced by the differences in the primary structures of the two peptides.
ASJC Scopus subject areas
- Colloid and Surface Chemistry