Sickle cell vaso-occlusion

Elaine Y. Chiang, Paul S. Frenette

Research output: Contribution to journalReview article

98 Scopus citations

Abstract

The vaso-occlusion model has evolved impressively over the past several decades from polymerization-based concepts to a complex, wide-ranging schema that involves multistep, heterogeneous, and interdependent interactions among sickle erythrocytes (SSRBCs), adherent leukocytes, endothelial cells, plasma proteins, and other factors. Endothelial activation, induced directly or indirectly by the proinflammatory behavior of SSRBCs, is the most likely initiating step toward vaso-occlusion. Given the complexity and dynamic relationships of the potential mechanisms leading to vaso-occlusion, further in vivo studies in relevant sickle cell animal models will most likely yield the greatest advances and promote the development of novel, more effective therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)771-784
Number of pages14
JournalHematology/Oncology Clinics of North America
Volume19
Issue number5
DOIs
StatePublished - Oct 1 2005
Externally publishedYes

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ASJC Scopus subject areas

  • Hematology
  • Oncology

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