Sickle cell disease: Old discoveries, new concepts, and future promise

Paul S. Frenette, George F. Atweh

Research output: Contribution to journalReview article

236 Scopus citations

Abstract

The discovery of the molecular basis of sickle cell disease was an important landmark in molecular medicine. The modern tools of molecular and cellular biology have refined our understanding of its pathophysiology and facilitated the development of new therapies. In this review, we discuss some of the important advances in this field and the impediments that limit the impact of these advances.

Original languageEnglish (US)
Pages (from-to)850-858
Number of pages9
JournalJournal of Clinical Investigation
Volume117
Issue number4
DOIs
StatePublished - Apr 2 2007
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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