Sickle cell disease: Old discoveries, new concepts, and future promise

Paul S. Frenette, George F. Atweh

Research output: Contribution to journalReview articlepeer-review

266 Scopus citations


The discovery of the molecular basis of sickle cell disease was an important landmark in molecular medicine. The modern tools of molecular and cellular biology have refined our understanding of its pathophysiology and facilitated the development of new therapies. In this review, we discuss some of the important advances in this field and the impediments that limit the impact of these advances.

Original languageEnglish (US)
Pages (from-to)850-858
Number of pages9
JournalJournal of Clinical Investigation
Issue number4
StatePublished - Apr 2 2007
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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