Sickle cell disease: Old discoveries, new concepts, and future promise

Paul S. Frenette; George F. Atweh

doi:10.1172/JCI30920

Sickle cell disease: Old discoveries, new concepts, and future promise

Paul S. Frenette, George F. Atweh

Research output: Contribution to journal › Review article › peer-review

287 Scopus citations

Abstract

The discovery of the molecular basis of sickle cell disease was an important landmark in molecular medicine. The modern tools of molecular and cellular biology have refined our understanding of its pathophysiology and facilitated the development of new therapies. In this review, we discuss some of the important advances in this field and the impediments that limit the impact of these advances.

Original language	English (US)
Pages (from-to)	850-858
Number of pages	9
Journal	Journal of Clinical Investigation
Volume	117
Issue number	4
DOIs	https://doi.org/10.1172/JCI30920
State	Published - Apr 2 2007
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1172/JCI30920

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abstract = "The discovery of the molecular basis of sickle cell disease was an important landmark in molecular medicine. The modern tools of molecular and cellular biology have refined our understanding of its pathophysiology and facilitated the development of new therapies. In this review, we discuss some of the important advances in this field and the impediments that limit the impact of these advances.",

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Sickle cell disease: Old discoveries, new concepts, and future promise

Abstract

ASJC Scopus subject areas

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