Short-term single-blind fluvoxamine treatment of pathological gambling

Eric Hollander, Concetta M. DeCaria, Eduardo Mari, Cheryl M. Wong, Serge Mosovich, Robert Grossman, Tomer Begaz

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

Objective: The authors' goal was to assess the efficacy and tolerability of the selective serotonin reuptake inhibitor fluvoxamine in the treatment of pathological gambling. Method: Sixteen patients with pathological gambling entered an 8-week placebo lead-in phase, and 10 of these patients completed an 8-week single-blind fluvoxamine trial. Results: Seven of the 10 patients who completed the fluvoxamine trial were judged treatment responders at the end of the study: 1) they had greater than 25% decreases in their gambling behavior scores on the pathological gambling modification of the Yale-Brown Obsessive Compulsive Scale, and 2) their clinician-rated Clinical Global Impression scores for gambling severity were very much improved or much improved. Fluvoxamine treatment resulted in gambling abstinence in seven of the 10 patients. Conclusions: Findings from this preliminary study suggest that fluvoxamine may be effective in reducing the urge to gamble. Randomized placebo-controlled and maintenance trials are required to confirm these findings and to determine whether improvement persists.

Original languageEnglish (US)
Pages (from-to)1781-1783
Number of pages3
JournalAmerican Journal of Psychiatry
Volume155
Issue number12
StatePublished - Dec 1998
Externally publishedYes

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Fluvoxamine
Gambling
Therapeutics
Placebos
Serotonin Uptake Inhibitors
Maintenance

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Hollander, E., DeCaria, C. M., Mari, E., Wong, C. M., Mosovich, S., Grossman, R., & Begaz, T. (1998). Short-term single-blind fluvoxamine treatment of pathological gambling. American Journal of Psychiatry, 155(12), 1781-1783.

Short-term single-blind fluvoxamine treatment of pathological gambling. / Hollander, Eric; DeCaria, Concetta M.; Mari, Eduardo; Wong, Cheryl M.; Mosovich, Serge; Grossman, Robert; Begaz, Tomer.

In: American Journal of Psychiatry, Vol. 155, No. 12, 12.1998, p. 1781-1783.

Research output: Contribution to journalArticle

Hollander, E, DeCaria, CM, Mari, E, Wong, CM, Mosovich, S, Grossman, R & Begaz, T 1998, 'Short-term single-blind fluvoxamine treatment of pathological gambling', American Journal of Psychiatry, vol. 155, no. 12, pp. 1781-1783.
Hollander E, DeCaria CM, Mari E, Wong CM, Mosovich S, Grossman R et al. Short-term single-blind fluvoxamine treatment of pathological gambling. American Journal of Psychiatry. 1998 Dec;155(12):1781-1783.
Hollander, Eric ; DeCaria, Concetta M. ; Mari, Eduardo ; Wong, Cheryl M. ; Mosovich, Serge ; Grossman, Robert ; Begaz, Tomer. / Short-term single-blind fluvoxamine treatment of pathological gambling. In: American Journal of Psychiatry. 1998 ; Vol. 155, No. 12. pp. 1781-1783.
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