Short-term outcomes of children with febrile status epilepticus

Shlomo Shinnar, John M. Pellock, Anne T. Berg, Christine O'Dell, Susan M. Driscoll, Joseph Maytal, Solomon L. Moshe, Robert J. Delorenzo

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Febrile status epilepticus (SE) represents the extreme end of the complex febrile seizure spectrum. If there are significant sequelae to febrile seizures, they should be more common in this group. We have prospectively identified 180 children aged 1 month to 10 years who presented with febrile SE over a 10-year period in Bronx, New York, and Richmond, Virginia. They were compared with 244 children who presented with their first febrile seizure (not SE) in a prospective study done in the Bronx. The mean age of the children with febrile SE was 1.92 years, and of the comparison group, 1.85 years. Duration of SE was 30-59 min in 103 (58%), 60-119 rain in 43 (24%), and ≥120 min in 34 (18%). Focal features were present in 64 (35%) of cases. There were no deaths and no cases of new cognitive or motor handicap. Children with febrile SE were more likely to be neurologically abnormal (20% vs. 5%; p < 0.001), to have a history of neonatal seizures (3% vs. 0; p = 0.006) and a family history of epilepsy (11% vs. 5%; p = 0.05) and less likely to have a family history of febrile seizures (15% vs. 27%; p = 0.01) than were children in the comparison group. The short-term morbidity and mortality of febrile SE are low. There are differences in the types of children who have febrile SE compared with those who experience briefer febrile seizures. Long-term follow-up of this cohort may provide insight into the relationship of prolonged febrile seizures and subsequent mesial temporal sclerosis.

Original languageEnglish (US)
Pages (from-to)47-53
Number of pages7
JournalEpilepsia
Volume42
Issue number1
DOIs
StatePublished - 2001

Fingerprint

Status Epilepticus
Febrile Seizures
Fever
Rain
Sclerosis
Epilepsy
Seizures
Prospective Studies
Morbidity
Mortality

Keywords

  • Children
  • Epilepsy
  • Etiology
  • Seizure
  • Status epilepticus

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Shinnar, S., Pellock, J. M., Berg, A. T., O'Dell, C., Driscoll, S. M., Maytal, J., ... Delorenzo, R. J. (2001). Short-term outcomes of children with febrile status epilepticus. Epilepsia, 42(1), 47-53. https://doi.org/10.1046/j.1528-1157.2001.10000.x

Short-term outcomes of children with febrile status epilepticus. / Shinnar, Shlomo; Pellock, John M.; Berg, Anne T.; O'Dell, Christine; Driscoll, Susan M.; Maytal, Joseph; Moshe, Solomon L.; Delorenzo, Robert J.

In: Epilepsia, Vol. 42, No. 1, 2001, p. 47-53.

Research output: Contribution to journalArticle

Shinnar, S, Pellock, JM, Berg, AT, O'Dell, C, Driscoll, SM, Maytal, J, Moshe, SL & Delorenzo, RJ 2001, 'Short-term outcomes of children with febrile status epilepticus', Epilepsia, vol. 42, no. 1, pp. 47-53. https://doi.org/10.1046/j.1528-1157.2001.10000.x
Shinnar, Shlomo ; Pellock, John M. ; Berg, Anne T. ; O'Dell, Christine ; Driscoll, Susan M. ; Maytal, Joseph ; Moshe, Solomon L. ; Delorenzo, Robert J. / Short-term outcomes of children with febrile status epilepticus. In: Epilepsia. 2001 ; Vol. 42, No. 1. pp. 47-53.
@article{c7a22f77c44e43dc8812d9e5ed6ec344,
title = "Short-term outcomes of children with febrile status epilepticus",
abstract = "Febrile status epilepticus (SE) represents the extreme end of the complex febrile seizure spectrum. If there are significant sequelae to febrile seizures, they should be more common in this group. We have prospectively identified 180 children aged 1 month to 10 years who presented with febrile SE over a 10-year period in Bronx, New York, and Richmond, Virginia. They were compared with 244 children who presented with their first febrile seizure (not SE) in a prospective study done in the Bronx. The mean age of the children with febrile SE was 1.92 years, and of the comparison group, 1.85 years. Duration of SE was 30-59 min in 103 (58{\%}), 60-119 rain in 43 (24{\%}), and ≥120 min in 34 (18{\%}). Focal features were present in 64 (35{\%}) of cases. There were no deaths and no cases of new cognitive or motor handicap. Children with febrile SE were more likely to be neurologically abnormal (20{\%} vs. 5{\%}; p < 0.001), to have a history of neonatal seizures (3{\%} vs. 0; p = 0.006) and a family history of epilepsy (11{\%} vs. 5{\%}; p = 0.05) and less likely to have a family history of febrile seizures (15{\%} vs. 27{\%}; p = 0.01) than were children in the comparison group. The short-term morbidity and mortality of febrile SE are low. There are differences in the types of children who have febrile SE compared with those who experience briefer febrile seizures. Long-term follow-up of this cohort may provide insight into the relationship of prolonged febrile seizures and subsequent mesial temporal sclerosis.",
keywords = "Children, Epilepsy, Etiology, Seizure, Status epilepticus",
author = "Shlomo Shinnar and Pellock, {John M.} and Berg, {Anne T.} and Christine O'Dell and Driscoll, {Susan M.} and Joseph Maytal and Moshe, {Solomon L.} and Delorenzo, {Robert J.}",
year = "2001",
doi = "10.1046/j.1528-1157.2001.10000.x",
language = "English (US)",
volume = "42",
pages = "47--53",
journal = "Epilepsia",
issn = "0013-9580",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Short-term outcomes of children with febrile status epilepticus

AU - Shinnar, Shlomo

AU - Pellock, John M.

AU - Berg, Anne T.

AU - O'Dell, Christine

AU - Driscoll, Susan M.

AU - Maytal, Joseph

AU - Moshe, Solomon L.

AU - Delorenzo, Robert J.

PY - 2001

Y1 - 2001

N2 - Febrile status epilepticus (SE) represents the extreme end of the complex febrile seizure spectrum. If there are significant sequelae to febrile seizures, they should be more common in this group. We have prospectively identified 180 children aged 1 month to 10 years who presented with febrile SE over a 10-year period in Bronx, New York, and Richmond, Virginia. They were compared with 244 children who presented with their first febrile seizure (not SE) in a prospective study done in the Bronx. The mean age of the children with febrile SE was 1.92 years, and of the comparison group, 1.85 years. Duration of SE was 30-59 min in 103 (58%), 60-119 rain in 43 (24%), and ≥120 min in 34 (18%). Focal features were present in 64 (35%) of cases. There were no deaths and no cases of new cognitive or motor handicap. Children with febrile SE were more likely to be neurologically abnormal (20% vs. 5%; p < 0.001), to have a history of neonatal seizures (3% vs. 0; p = 0.006) and a family history of epilepsy (11% vs. 5%; p = 0.05) and less likely to have a family history of febrile seizures (15% vs. 27%; p = 0.01) than were children in the comparison group. The short-term morbidity and mortality of febrile SE are low. There are differences in the types of children who have febrile SE compared with those who experience briefer febrile seizures. Long-term follow-up of this cohort may provide insight into the relationship of prolonged febrile seizures and subsequent mesial temporal sclerosis.

AB - Febrile status epilepticus (SE) represents the extreme end of the complex febrile seizure spectrum. If there are significant sequelae to febrile seizures, they should be more common in this group. We have prospectively identified 180 children aged 1 month to 10 years who presented with febrile SE over a 10-year period in Bronx, New York, and Richmond, Virginia. They were compared with 244 children who presented with their first febrile seizure (not SE) in a prospective study done in the Bronx. The mean age of the children with febrile SE was 1.92 years, and of the comparison group, 1.85 years. Duration of SE was 30-59 min in 103 (58%), 60-119 rain in 43 (24%), and ≥120 min in 34 (18%). Focal features were present in 64 (35%) of cases. There were no deaths and no cases of new cognitive or motor handicap. Children with febrile SE were more likely to be neurologically abnormal (20% vs. 5%; p < 0.001), to have a history of neonatal seizures (3% vs. 0; p = 0.006) and a family history of epilepsy (11% vs. 5%; p = 0.05) and less likely to have a family history of febrile seizures (15% vs. 27%; p = 0.01) than were children in the comparison group. The short-term morbidity and mortality of febrile SE are low. There are differences in the types of children who have febrile SE compared with those who experience briefer febrile seizures. Long-term follow-up of this cohort may provide insight into the relationship of prolonged febrile seizures and subsequent mesial temporal sclerosis.

KW - Children

KW - Epilepsy

KW - Etiology

KW - Seizure

KW - Status epilepticus

UR - http://www.scopus.com/inward/record.url?scp=0035109542&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035109542&partnerID=8YFLogxK

U2 - 10.1046/j.1528-1157.2001.10000.x

DO - 10.1046/j.1528-1157.2001.10000.x

M3 - Article

C2 - 11207784

AN - SCOPUS:0035109542

VL - 42

SP - 47

EP - 53

JO - Epilepsia

JF - Epilepsia

SN - 0013-9580

IS - 1

ER -