Short Physical Performance Battery and all-cause mortality

Systematic review and meta-analysis

Rita Pavasini, Jack Guralnik, Justin C. Brown, Mauro di Bari, Matteo Cesari, Francesco Landi, Bert Vaes, Delphine Legrand, Joe Verghese, Cuiling Wang, Sari Stenholm, Luigi Ferrucci, Jennifer C. Lai, Anna Arnau Bartes, Joan Espaulella, Montserrat Ferrer, Jae Young Lim, Kristine E. Ensrud, Peggy Cawthon, Anna Turusheva & 8 others Elena Frolova, Yves Rolland, Valerie Lauwers, Andrea Corsonello, Gregory D. Kirk, Roberto Ferrari, Stefano Volpato, Gianluca Campo

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Background: The Short Physical Performance Battery (SPPB) is a well-established tool to assess lower extremity physical performance status. Its predictive ability for all-cause mortality has been sparsely reported, but with conflicting results in different subsets of participants. The aim of this study was to perform a meta-analysis investigating the relationship between SPPB score and all-cause mortality. Methods: Articles were searched in MEDLINE, the Cochrane Library, Google Scholar, and BioMed Central between July and September 2015 and updated in January 2016. Inclusion criteria were observational studies; >50 participants; stratification of population according to SPPB value; data on all-cause mortality; English language publications. Twenty-four articles were selected from available evidence. Data of interest (i.e., clinical characteristics, information after stratification of the sample into four SPPB groups [0-3, 4-6, 7-9, 10-12]) were retrieved from the articles and/or obtained by the study authors. The odds ratio (OR) and/or hazard ratio (HR) was obtained for all-cause mortality according to SPPB category (with SPPB scores 10-12 considered as reference) with adjustment for age, sex, and body mass index. Results: Standardized data were obtained for 17 studies (n=16,534, mean age 76±3years). As compared to SPPB scores 10-12, values of 0-3 (OR 3.25, 95%CI 2.86-3.79), 4-6 (OR 2.14, 95%CI 1.92-2.39), and 7-9 (OR 1.50, 95%CI 1.32-1.71) were each associated with an increased risk of all-cause mortality. The association between poor performance on SPPB and all-cause mortality remained highly consistent independent of follow-up length, subsets of participants, geographic area, and age of the population. Random effects meta-regression showed that OR for all-cause mortality with SPPB values 7-9 was higher in the younger population, diabetics, and men. Conclusions: An SPPB score lower than 10 is predictive of all-cause mortality. The systematic implementation of the SPPB in clinical practice settings may provide useful prognostic information about the risk of all-cause mortality. Moreover, the SPPB could be used as a surrogate endpoint of all-cause mortality in trials needing to quantify benefit and health improvements of specific treatments or rehabilitation programs. The study protocol was published on PROSPERO (CRD42015024916).

Original languageEnglish (US)
Article number215
JournalBMC Medicine
Volume14
Issue number1
DOIs
StatePublished - Dec 22 2016

Fingerprint

Meta-Analysis
Mortality
Odds Ratio
Population
Aptitude
Insurance Benefits
MEDLINE
Libraries
Observational Studies
Publications
Lower Extremity
Body Mass Index
Language
Rehabilitation
Biomarkers

Keywords

  • All-cause mortality
  • Meta-analysis
  • Physical function
  • Short Physical Performance Battery

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pavasini, R., Guralnik, J., Brown, J. C., di Bari, M., Cesari, M., Landi, F., ... Campo, G. (2016). Short Physical Performance Battery and all-cause mortality: Systematic review and meta-analysis. BMC Medicine, 14(1), [215]. https://doi.org/10.1186/s12916-016-0763-7

Short Physical Performance Battery and all-cause mortality : Systematic review and meta-analysis. / Pavasini, Rita; Guralnik, Jack; Brown, Justin C.; di Bari, Mauro; Cesari, Matteo; Landi, Francesco; Vaes, Bert; Legrand, Delphine; Verghese, Joe; Wang, Cuiling; Stenholm, Sari; Ferrucci, Luigi; Lai, Jennifer C.; Bartes, Anna Arnau; Espaulella, Joan; Ferrer, Montserrat; Lim, Jae Young; Ensrud, Kristine E.; Cawthon, Peggy; Turusheva, Anna; Frolova, Elena; Rolland, Yves; Lauwers, Valerie; Corsonello, Andrea; Kirk, Gregory D.; Ferrari, Roberto; Volpato, Stefano; Campo, Gianluca.

In: BMC Medicine, Vol. 14, No. 1, 215, 22.12.2016.

Research output: Contribution to journalArticle

Pavasini, R, Guralnik, J, Brown, JC, di Bari, M, Cesari, M, Landi, F, Vaes, B, Legrand, D, Verghese, J, Wang, C, Stenholm, S, Ferrucci, L, Lai, JC, Bartes, AA, Espaulella, J, Ferrer, M, Lim, JY, Ensrud, KE, Cawthon, P, Turusheva, A, Frolova, E, Rolland, Y, Lauwers, V, Corsonello, A, Kirk, GD, Ferrari, R, Volpato, S & Campo, G 2016, 'Short Physical Performance Battery and all-cause mortality: Systematic review and meta-analysis', BMC Medicine, vol. 14, no. 1, 215. https://doi.org/10.1186/s12916-016-0763-7
Pavasini, Rita ; Guralnik, Jack ; Brown, Justin C. ; di Bari, Mauro ; Cesari, Matteo ; Landi, Francesco ; Vaes, Bert ; Legrand, Delphine ; Verghese, Joe ; Wang, Cuiling ; Stenholm, Sari ; Ferrucci, Luigi ; Lai, Jennifer C. ; Bartes, Anna Arnau ; Espaulella, Joan ; Ferrer, Montserrat ; Lim, Jae Young ; Ensrud, Kristine E. ; Cawthon, Peggy ; Turusheva, Anna ; Frolova, Elena ; Rolland, Yves ; Lauwers, Valerie ; Corsonello, Andrea ; Kirk, Gregory D. ; Ferrari, Roberto ; Volpato, Stefano ; Campo, Gianluca. / Short Physical Performance Battery and all-cause mortality : Systematic review and meta-analysis. In: BMC Medicine. 2016 ; Vol. 14, No. 1.
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T2 - Systematic review and meta-analysis

AU - Pavasini, Rita

AU - Guralnik, Jack

AU - Brown, Justin C.

AU - di Bari, Mauro

AU - Cesari, Matteo

AU - Landi, Francesco

AU - Vaes, Bert

AU - Legrand, Delphine

AU - Verghese, Joe

AU - Wang, Cuiling

AU - Stenholm, Sari

AU - Ferrucci, Luigi

AU - Lai, Jennifer C.

AU - Bartes, Anna Arnau

AU - Espaulella, Joan

AU - Ferrer, Montserrat

AU - Lim, Jae Young

AU - Ensrud, Kristine E.

AU - Cawthon, Peggy

AU - Turusheva, Anna

AU - Frolova, Elena

AU - Rolland, Yves

AU - Lauwers, Valerie

AU - Corsonello, Andrea

AU - Kirk, Gregory D.

AU - Ferrari, Roberto

AU - Volpato, Stefano

AU - Campo, Gianluca

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Y1 - 2016/12/22

N2 - Background: The Short Physical Performance Battery (SPPB) is a well-established tool to assess lower extremity physical performance status. Its predictive ability for all-cause mortality has been sparsely reported, but with conflicting results in different subsets of participants. The aim of this study was to perform a meta-analysis investigating the relationship between SPPB score and all-cause mortality. Methods: Articles were searched in MEDLINE, the Cochrane Library, Google Scholar, and BioMed Central between July and September 2015 and updated in January 2016. Inclusion criteria were observational studies; >50 participants; stratification of population according to SPPB value; data on all-cause mortality; English language publications. Twenty-four articles were selected from available evidence. Data of interest (i.e., clinical characteristics, information after stratification of the sample into four SPPB groups [0-3, 4-6, 7-9, 10-12]) were retrieved from the articles and/or obtained by the study authors. The odds ratio (OR) and/or hazard ratio (HR) was obtained for all-cause mortality according to SPPB category (with SPPB scores 10-12 considered as reference) with adjustment for age, sex, and body mass index. Results: Standardized data were obtained for 17 studies (n=16,534, mean age 76±3years). As compared to SPPB scores 10-12, values of 0-3 (OR 3.25, 95%CI 2.86-3.79), 4-6 (OR 2.14, 95%CI 1.92-2.39), and 7-9 (OR 1.50, 95%CI 1.32-1.71) were each associated with an increased risk of all-cause mortality. The association between poor performance on SPPB and all-cause mortality remained highly consistent independent of follow-up length, subsets of participants, geographic area, and age of the population. Random effects meta-regression showed that OR for all-cause mortality with SPPB values 7-9 was higher in the younger population, diabetics, and men. Conclusions: An SPPB score lower than 10 is predictive of all-cause mortality. The systematic implementation of the SPPB in clinical practice settings may provide useful prognostic information about the risk of all-cause mortality. Moreover, the SPPB could be used as a surrogate endpoint of all-cause mortality in trials needing to quantify benefit and health improvements of specific treatments or rehabilitation programs. The study protocol was published on PROSPERO (CRD42015024916).

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KW - All-cause mortality

KW - Meta-analysis

KW - Physical function

KW - Short Physical Performance Battery

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