Short latency cerebellar modulation of the basal ganglia

Christopher H. Chen, Rachel Fremont, Eduardo E. Arteaga-Bracho, Kamran Khodakhah

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

The graceful, purposeful motion of our body is an engineering feat that remains unparalleled in robotic devices using advanced artificial intelligence. Much of the information required for complex movements is generated by the cerebellum and the basal ganglia in conjunction with the cortex. Cerebellum and basal ganglia have been thought to communicate with each other only through slow, multi-synaptic cortical loops, begging the question as to how they coordinate their outputs in real time. We found that the cerebellum rapidly modulates the activity of the striatum via a disynaptic pathway in mice. Under physiological conditions, this short latency pathway was capable of facilitating optimal motor control by allowing the basal ganglia to incorporate time-sensitive cerebellar information and by guiding the sign of cortico-striatal plasticity. Conversely, under pathological condition, this pathway relayed aberrant cerebellar activity to the basal ganglia to cause dystonia.

Original languageEnglish (US)
Pages (from-to)1767-1775
Number of pages9
JournalNature Neuroscience
Volume17
Issue number12
DOIs
StatePublished - Jan 1 2014

Fingerprint

Basal Ganglia
Cerebellum
Corpus Striatum
Dystonia
Artificial Intelligence
Robotics
Equipment and Supplies

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Short latency cerebellar modulation of the basal ganglia. / Chen, Christopher H.; Fremont, Rachel; Arteaga-Bracho, Eduardo E.; Khodakhah, Kamran.

In: Nature Neuroscience, Vol. 17, No. 12, 01.01.2014, p. 1767-1775.

Research output: Contribution to journalArticle

Chen, CH, Fremont, R, Arteaga-Bracho, EE & Khodakhah, K 2014, 'Short latency cerebellar modulation of the basal ganglia', Nature Neuroscience, vol. 17, no. 12, pp. 1767-1775. https://doi.org/10.1038/nn.3868
Chen, Christopher H. ; Fremont, Rachel ; Arteaga-Bracho, Eduardo E. ; Khodakhah, Kamran. / Short latency cerebellar modulation of the basal ganglia. In: Nature Neuroscience. 2014 ; Vol. 17, No. 12. pp. 1767-1775.
@article{8783c2cdf6dd499592c39edc09ee8c93,
title = "Short latency cerebellar modulation of the basal ganglia",
abstract = "The graceful, purposeful motion of our body is an engineering feat that remains unparalleled in robotic devices using advanced artificial intelligence. Much of the information required for complex movements is generated by the cerebellum and the basal ganglia in conjunction with the cortex. Cerebellum and basal ganglia have been thought to communicate with each other only through slow, multi-synaptic cortical loops, begging the question as to how they coordinate their outputs in real time. We found that the cerebellum rapidly modulates the activity of the striatum via a disynaptic pathway in mice. Under physiological conditions, this short latency pathway was capable of facilitating optimal motor control by allowing the basal ganglia to incorporate time-sensitive cerebellar information and by guiding the sign of cortico-striatal plasticity. Conversely, under pathological condition, this pathway relayed aberrant cerebellar activity to the basal ganglia to cause dystonia.",
author = "Chen, {Christopher H.} and Rachel Fremont and Arteaga-Bracho, {Eduardo E.} and Kamran Khodakhah",
year = "2014",
month = "1",
day = "1",
doi = "10.1038/nn.3868",
language = "English (US)",
volume = "17",
pages = "1767--1775",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "12",

}

TY - JOUR

T1 - Short latency cerebellar modulation of the basal ganglia

AU - Chen, Christopher H.

AU - Fremont, Rachel

AU - Arteaga-Bracho, Eduardo E.

AU - Khodakhah, Kamran

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The graceful, purposeful motion of our body is an engineering feat that remains unparalleled in robotic devices using advanced artificial intelligence. Much of the information required for complex movements is generated by the cerebellum and the basal ganglia in conjunction with the cortex. Cerebellum and basal ganglia have been thought to communicate with each other only through slow, multi-synaptic cortical loops, begging the question as to how they coordinate their outputs in real time. We found that the cerebellum rapidly modulates the activity of the striatum via a disynaptic pathway in mice. Under physiological conditions, this short latency pathway was capable of facilitating optimal motor control by allowing the basal ganglia to incorporate time-sensitive cerebellar information and by guiding the sign of cortico-striatal plasticity. Conversely, under pathological condition, this pathway relayed aberrant cerebellar activity to the basal ganglia to cause dystonia.

AB - The graceful, purposeful motion of our body is an engineering feat that remains unparalleled in robotic devices using advanced artificial intelligence. Much of the information required for complex movements is generated by the cerebellum and the basal ganglia in conjunction with the cortex. Cerebellum and basal ganglia have been thought to communicate with each other only through slow, multi-synaptic cortical loops, begging the question as to how they coordinate their outputs in real time. We found that the cerebellum rapidly modulates the activity of the striatum via a disynaptic pathway in mice. Under physiological conditions, this short latency pathway was capable of facilitating optimal motor control by allowing the basal ganglia to incorporate time-sensitive cerebellar information and by guiding the sign of cortico-striatal plasticity. Conversely, under pathological condition, this pathway relayed aberrant cerebellar activity to the basal ganglia to cause dystonia.

UR - http://www.scopus.com/inward/record.url?scp=84925223399&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925223399&partnerID=8YFLogxK

U2 - 10.1038/nn.3868

DO - 10.1038/nn.3868

M3 - Article

VL - 17

SP - 1767

EP - 1775

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 12

ER -