Short communication: Methamphetamine treatment increases in vitro and in vivo HIV replication

Sima Shelly Toussi, Aviva Joseph, Jian Hua Zheng, Monica Dutta, Laura Santambrogio, Harris Goldstein

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

To delineate the mechanistic basis for the epidemiological association between methamphetamine use and accelerated progression to AIDS, we evaluated the direct in vitro and in vivo effects of methamphetamine on HIV-1 replication. Methamphetamine administration significantly increased HIV-1 production by both HIV-infected monocytes and CD4 T lymphocytes in vitro. In addition, in vivo methamphetamine treatment increased HIV production and viremia in mice transgenic for a replication-competent HIV provirus and human cyclinT1. Methamphetamine activated transcription of the HIV long terminal repeat (LTR) regulatory region, was associated with nuclear translocation of NF-κB. Our results provide further insights into the mechanisms by which methamphetamine accelerates disease course in HIV-infected individuals.

Original languageEnglish (US)
Pages (from-to)1117-1121
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume25
Issue number11
DOIs
StatePublished - Nov 1 2009

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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