SHMTool: A webserver for comparative analysis of somatic hypermutation datasets

Thomas MacCarthy, Sergio Roa, Matthew D. Scharff, Aviv Bergman

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

The somatic hypermutation (SHM) of Immunoglobulin variable (V) regions is a key process in the generation of antibody diversity. The growing number of datasets of point mutations that occur during SHM in mice and humans often include comparisons between wild-type and individuals or strains genetically defective in the repair mechanisms that contribute to SHM. However, it has been difficult to compare the results of different studies because the analyses have not been standardized for criteria such as correction for base composition and the inclusion of unique mutations. If many mutations are involved, the analysis can also be time consuming. To overcome these problems and facilitate a standardized analysis and display of similar data, we present a webserver (SHMTool) for comparing SHM datasets, available at http://scb.aecom.yu.edu/shmtool.

Original languageEnglish (US)
Pages (from-to)137-141
Number of pages5
JournalDNA Repair
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2009

Keywords

  • Mutation analysis
  • Somatic hypermutation
  • Standardization

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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