TY - JOUR
T1 - Sex-specific impact of severe obesity in the outcomes of hospitalized patients with COVID-19
T2 - a large retrospective study from the Bronx, New York
AU - Guerson-Gil, Arcelia
AU - Palaiodimos, Leonidas
AU - Assa, Andrei
AU - Karamanis, Dimitris
AU - Kokkinidis, Damianos
AU - Chamorro-Pareja, Natalia
AU - Kishore, Preeti
AU - Leider, Jason M.
AU - Brandt, Lawrence J.
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2021/9
Y1 - 2021/9
N2 - It has been demonstrated that obesity is an independent risk factor for worse outcomes in patients with COVID-19. Our objectives were to investigate which classes of obesity are associated with higher in-hospital mortality and to assess the association between obesity and systemic inflammation. This was a retrospective study which included consecutive hospitalized patients with COVID-19 in a tertiary center. Three thousand five hundred thirty patients were included in this analysis (female sex: 1579, median age: 65 years). The median body mass index (BMI) was 28.8 kg/m2. In the overall cohort, a J-shaped association between BMI and in-hospital mortality was depicted. In the subgroup of men, BMI 35–39.9 kg/m2 and BMI ≥40 kg/m2 were found to have significant association with higher in-hospital mortality, while only BMI ≥40 kg/m2 was found significant in the subgroup of women. No significant association between BMI and IL-6 was noted. Obesity classes II and III in men and obesity class III in women were independently associated with higher in-hospital mortality in patients with COVID-19. The male population with severe obesity was the one that mainly drove this association. No significant association between BMI and IL-6 was noted.
AB - It has been demonstrated that obesity is an independent risk factor for worse outcomes in patients with COVID-19. Our objectives were to investigate which classes of obesity are associated with higher in-hospital mortality and to assess the association between obesity and systemic inflammation. This was a retrospective study which included consecutive hospitalized patients with COVID-19 in a tertiary center. Three thousand five hundred thirty patients were included in this analysis (female sex: 1579, median age: 65 years). The median body mass index (BMI) was 28.8 kg/m2. In the overall cohort, a J-shaped association between BMI and in-hospital mortality was depicted. In the subgroup of men, BMI 35–39.9 kg/m2 and BMI ≥40 kg/m2 were found to have significant association with higher in-hospital mortality, while only BMI ≥40 kg/m2 was found significant in the subgroup of women. No significant association between BMI and IL-6 was noted. Obesity classes II and III in men and obesity class III in women were independently associated with higher in-hospital mortality in patients with COVID-19. The male population with severe obesity was the one that mainly drove this association. No significant association between BMI and IL-6 was noted.
KW - COVID-19
KW - IL-6
KW - Inflammation
KW - Mortality
KW - Novel coronavirus
KW - Obesity
KW - Observational study
KW - Risk factor
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85105484737&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85105484737&partnerID=8YFLogxK
U2 - 10.1007/s10096-021-04260-z
DO - 10.1007/s10096-021-04260-z
M3 - Article
C2 - 33956286
AN - SCOPUS:85105484737
SN - 0934-9723
VL - 40
SP - 1963
EP - 1974
JO - European Journal of Clinical Microbiology and Infectious Diseases
JF - European Journal of Clinical Microbiology and Infectious Diseases
IS - 9
ER -
