Sex hormones in women with and without migraine

Jelena M. Pavlovic, Amanda A. Allshouse, Nanette F. Santoro, Sybil L. Crawford, Rebecca C. Thurston, Genevieve S. Neal-Perry, Richard B. Lipton, Carol A. Derby

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objective: To compare daily sex hormone levels and rates of change between women with history of migraine and controls. Methods: History of migraine, daily headache diaries, and daily hormone data were collected in ovulatory cycles of pre- and early perimenopausal women in the Study of Women's Health Across the Nation. Peak hormone levels, average daily levels, and within-woman day-to-day rates of decline over the 5 days following each hormone peak were calculated in ovulatory cycles for conjugated urinary estrogens (E1c), pregnanediol-3-glucuronide, luteinizing hormone, and follicle-stimulating hormone. Comparisons were made between migraineurs and controls using 2-sample t tests on the log scale with results reported as geometric means. Results: The sample included 114 women with history of migraine and 223 controls. Analyses of within-woman rates of decline showed that E1c decline over the 2 days following the luteal peak was greater in migraineurs for both absolute rate of decline (33.8 [95% confidence interval 28.0-40.8] pg/mgCr vs 23.1 [95% confidence interval 20.1-26.6] pg/mgCr, p 0.002) and percent change (40% vs 30%, p <0.001). There was no significant difference between migraineurs and controls in absolute peak or daily E1c, pregnanediol-3-glucuronide, luteinizing hormone, and follicle-stimulating hormone levels. Secondary analyses demonstrated that, among migraineurs, the rate of E1c decline did not differ according to whether a headache occurred during the cycle studied. Conclusions: Migraineurs are characterized by faster late luteal phase E1c decline compared to controls. The timing and rate of estrogen withdrawal before menses may be a marker of neuroendocrine vulnerability in women with migraine.

Original languageEnglish (US)
Pages (from-to)49-56
Number of pages8
JournalNeurology
Volume87
Issue number1
DOIs
StatePublished - Jul 5 2016

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Gonadal Steroid Hormones
Migraine Disorders
Follicle Stimulating Hormone
Hormones
Luteinizing Hormone
Confidence Intervals
Conjugated (USP) Estrogens
Menstruation
Luteal Phase
Corpus Luteum
Women's Health
Headache
Estrogens

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Pavlovic, J. M., Allshouse, A. A., Santoro, N. F., Crawford, S. L., Thurston, R. C., Neal-Perry, G. S., ... Derby, C. A. (2016). Sex hormones in women with and without migraine. Neurology, 87(1), 49-56. https://doi.org/10.1212/WNL.0000000000002798

Sex hormones in women with and without migraine. / Pavlovic, Jelena M.; Allshouse, Amanda A.; Santoro, Nanette F.; Crawford, Sybil L.; Thurston, Rebecca C.; Neal-Perry, Genevieve S.; Lipton, Richard B.; Derby, Carol A.

In: Neurology, Vol. 87, No. 1, 05.07.2016, p. 49-56.

Research output: Contribution to journalArticle

Pavlovic, JM, Allshouse, AA, Santoro, NF, Crawford, SL, Thurston, RC, Neal-Perry, GS, Lipton, RB & Derby, CA 2016, 'Sex hormones in women with and without migraine', Neurology, vol. 87, no. 1, pp. 49-56. https://doi.org/10.1212/WNL.0000000000002798
Pavlovic JM, Allshouse AA, Santoro NF, Crawford SL, Thurston RC, Neal-Perry GS et al. Sex hormones in women with and without migraine. Neurology. 2016 Jul 5;87(1):49-56. https://doi.org/10.1212/WNL.0000000000002798
Pavlovic, Jelena M. ; Allshouse, Amanda A. ; Santoro, Nanette F. ; Crawford, Sybil L. ; Thurston, Rebecca C. ; Neal-Perry, Genevieve S. ; Lipton, Richard B. ; Derby, Carol A. / Sex hormones in women with and without migraine. In: Neurology. 2016 ; Vol. 87, No. 1. pp. 49-56.
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AU - Santoro, Nanette F.

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AU - Neal-Perry, Genevieve S.

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