Sex hormones are associated with right ventricular structure and function

The MESA-right ventricle study

Corey E. Ventetuolo, Pamela Ouyang, David A. Bluemke, Harikrishna Tandri, R. Graham Barr, Emilia Bagiella, Anne R. Cappola, Michael R. Bristow, Craig Johnson, Richard A. Kronmal, Jorge Kizer, Joao A C Lima, Steven M. Kawut

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Rationale: Sex hormones have effects on the left ventricle, but hormonal influences on the right ventricle (RV) are unknown. Objectives: We hypothesized that sex hormones would be associated with RV morphology in a large cohort free of cardiovascular disease. Methods: Sex hormones were measured by immunoassay and RV ejection fraction (RVEF), stroke volume (RVSV), mass, end-diastolic volume, and end-systolic volume (RVESV) were measured by cardiac magnetic resonance imaging in 1,957 men and 1,738 postmenopausal women. The relationship between each hormone and RV parameter was assessed by multivariate linear regression. Measurements and Main Results: Higher estradiol levels were associated with higher RVEF (β per 1 ln[nmol/L], 0.88; 95% confidence interval [CI], 0.32 to 1.43; P = 0.002) and lower RVESV (β per 1 ln[nmol/L], -0.87; 95% CI, -1.67 to 20.08; P = 0.03) in women using hormone therapy. In men, higher bioavailable testosterone levels were associated with higher RVSV (β per 1 ln[nmol/L], 1.97; 95% CI, 0.20 to 3.73; P = 0.03) and greater RV mass and volumes (P ≤ 0.01). Higher dehydroepiandrosterone levels were associated with higher RVSV (β per 1 ln[nmol/L], 1.37; 95% CI, 0.15 to 2.59; P = 0.03) and greater RV mass (β per 1 ln[nmol/L], 0.25; 95% CI, 0.00 to 0.49; P = 0.05) and volumes (P ≤ 0.001) in women. Conclusions: Higher estradiol levels were associated with better RV systolic function in women using hormone therapy. Higher levels of androgens were associated with greater RV mass and volumes in both sexes.

Original languageEnglish (US)
Pages (from-to)659-667
Number of pages9
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume183
Issue number5
DOIs
StatePublished - Mar 1 2011
Externally publishedYes

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Right Ventricular Function
Gonadal Steroid Hormones
Heart Ventricles
Confidence Intervals
Stroke Volume
Hormones
Estradiol
Dehydroepiandrosterone
Immunoassay
Androgens
Testosterone
Linear Models
Cardiovascular Diseases
Magnetic Resonance Imaging

Keywords

  • Right ventricle
  • Sex
  • Sex hormones

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Sex hormones are associated with right ventricular structure and function : The MESA-right ventricle study. / Ventetuolo, Corey E.; Ouyang, Pamela; Bluemke, David A.; Tandri, Harikrishna; Barr, R. Graham; Bagiella, Emilia; Cappola, Anne R.; Bristow, Michael R.; Johnson, Craig; Kronmal, Richard A.; Kizer, Jorge; Lima, Joao A C; Kawut, Steven M.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 183, No. 5, 01.03.2011, p. 659-667.

Research output: Contribution to journalArticle

Ventetuolo, CE, Ouyang, P, Bluemke, DA, Tandri, H, Barr, RG, Bagiella, E, Cappola, AR, Bristow, MR, Johnson, C, Kronmal, RA, Kizer, J, Lima, JAC & Kawut, SM 2011, 'Sex hormones are associated with right ventricular structure and function: The MESA-right ventricle study', American Journal of Respiratory and Critical Care Medicine, vol. 183, no. 5, pp. 659-667. https://doi.org/10.1164/rccm.201007-1027OC
Ventetuolo, Corey E. ; Ouyang, Pamela ; Bluemke, David A. ; Tandri, Harikrishna ; Barr, R. Graham ; Bagiella, Emilia ; Cappola, Anne R. ; Bristow, Michael R. ; Johnson, Craig ; Kronmal, Richard A. ; Kizer, Jorge ; Lima, Joao A C ; Kawut, Steven M. / Sex hormones are associated with right ventricular structure and function : The MESA-right ventricle study. In: American Journal of Respiratory and Critical Care Medicine. 2011 ; Vol. 183, No. 5. pp. 659-667.
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abstract = "Rationale: Sex hormones have effects on the left ventricle, but hormonal influences on the right ventricle (RV) are unknown. Objectives: We hypothesized that sex hormones would be associated with RV morphology in a large cohort free of cardiovascular disease. Methods: Sex hormones were measured by immunoassay and RV ejection fraction (RVEF), stroke volume (RVSV), mass, end-diastolic volume, and end-systolic volume (RVESV) were measured by cardiac magnetic resonance imaging in 1,957 men and 1,738 postmenopausal women. The relationship between each hormone and RV parameter was assessed by multivariate linear regression. Measurements and Main Results: Higher estradiol levels were associated with higher RVEF (β per 1 ln[nmol/L], 0.88; 95{\%} confidence interval [CI], 0.32 to 1.43; P = 0.002) and lower RVESV (β per 1 ln[nmol/L], -0.87; 95{\%} CI, -1.67 to 20.08; P = 0.03) in women using hormone therapy. In men, higher bioavailable testosterone levels were associated with higher RVSV (β per 1 ln[nmol/L], 1.97; 95{\%} CI, 0.20 to 3.73; P = 0.03) and greater RV mass and volumes (P ≤ 0.01). Higher dehydroepiandrosterone levels were associated with higher RVSV (β per 1 ln[nmol/L], 1.37; 95{\%} CI, 0.15 to 2.59; P = 0.03) and greater RV mass (β per 1 ln[nmol/L], 0.25; 95{\%} CI, 0.00 to 0.49; P = 0.05) and volumes (P ≤ 0.001) in women. Conclusions: Higher estradiol levels were associated with better RV systolic function in women using hormone therapy. Higher levels of androgens were associated with greater RV mass and volumes in both sexes.",
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T2 - The MESA-right ventricle study

AU - Ventetuolo, Corey E.

AU - Ouyang, Pamela

AU - Bluemke, David A.

AU - Tandri, Harikrishna

AU - Barr, R. Graham

AU - Bagiella, Emilia

AU - Cappola, Anne R.

AU - Bristow, Michael R.

AU - Johnson, Craig

AU - Kronmal, Richard A.

AU - Kizer, Jorge

AU - Lima, Joao A C

AU - Kawut, Steven M.

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N2 - Rationale: Sex hormones have effects on the left ventricle, but hormonal influences on the right ventricle (RV) are unknown. Objectives: We hypothesized that sex hormones would be associated with RV morphology in a large cohort free of cardiovascular disease. Methods: Sex hormones were measured by immunoassay and RV ejection fraction (RVEF), stroke volume (RVSV), mass, end-diastolic volume, and end-systolic volume (RVESV) were measured by cardiac magnetic resonance imaging in 1,957 men and 1,738 postmenopausal women. The relationship between each hormone and RV parameter was assessed by multivariate linear regression. Measurements and Main Results: Higher estradiol levels were associated with higher RVEF (β per 1 ln[nmol/L], 0.88; 95% confidence interval [CI], 0.32 to 1.43; P = 0.002) and lower RVESV (β per 1 ln[nmol/L], -0.87; 95% CI, -1.67 to 20.08; P = 0.03) in women using hormone therapy. In men, higher bioavailable testosterone levels were associated with higher RVSV (β per 1 ln[nmol/L], 1.97; 95% CI, 0.20 to 3.73; P = 0.03) and greater RV mass and volumes (P ≤ 0.01). Higher dehydroepiandrosterone levels were associated with higher RVSV (β per 1 ln[nmol/L], 1.37; 95% CI, 0.15 to 2.59; P = 0.03) and greater RV mass (β per 1 ln[nmol/L], 0.25; 95% CI, 0.00 to 0.49; P = 0.05) and volumes (P ≤ 0.001) in women. Conclusions: Higher estradiol levels were associated with better RV systolic function in women using hormone therapy. Higher levels of androgens were associated with greater RV mass and volumes in both sexes.

AB - Rationale: Sex hormones have effects on the left ventricle, but hormonal influences on the right ventricle (RV) are unknown. Objectives: We hypothesized that sex hormones would be associated with RV morphology in a large cohort free of cardiovascular disease. Methods: Sex hormones were measured by immunoassay and RV ejection fraction (RVEF), stroke volume (RVSV), mass, end-diastolic volume, and end-systolic volume (RVESV) were measured by cardiac magnetic resonance imaging in 1,957 men and 1,738 postmenopausal women. The relationship between each hormone and RV parameter was assessed by multivariate linear regression. Measurements and Main Results: Higher estradiol levels were associated with higher RVEF (β per 1 ln[nmol/L], 0.88; 95% confidence interval [CI], 0.32 to 1.43; P = 0.002) and lower RVESV (β per 1 ln[nmol/L], -0.87; 95% CI, -1.67 to 20.08; P = 0.03) in women using hormone therapy. In men, higher bioavailable testosterone levels were associated with higher RVSV (β per 1 ln[nmol/L], 1.97; 95% CI, 0.20 to 3.73; P = 0.03) and greater RV mass and volumes (P ≤ 0.01). Higher dehydroepiandrosterone levels were associated with higher RVSV (β per 1 ln[nmol/L], 1.37; 95% CI, 0.15 to 2.59; P = 0.03) and greater RV mass (β per 1 ln[nmol/L], 0.25; 95% CI, 0.00 to 0.49; P = 0.05) and volumes (P ≤ 0.001) in women. Conclusions: Higher estradiol levels were associated with better RV systolic function in women using hormone therapy. Higher levels of androgens were associated with greater RV mass and volumes in both sexes.

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