TY - JOUR
T1 - Sex hormones are associated with right ventricular structure and function
T2 - The MESA-right ventricle study
AU - Ventetuolo, Corey E.
AU - Ouyang, Pamela
AU - Bluemke, David A.
AU - Tandri, Harikrishna
AU - Barr, R. Graham
AU - Bagiella, Emilia
AU - Cappola, Anne R.
AU - Bristow, Michael R.
AU - Johnson, Craig
AU - Kronmal, Richard A.
AU - Kizer, Jorge R.
AU - Lima, Joao A.C.
AU - Kawut, Steven M.
PY - 2011/3/1
Y1 - 2011/3/1
N2 - Rationale: Sex hormones have effects on the left ventricle, but hormonal influences on the right ventricle (RV) are unknown. Objectives: We hypothesized that sex hormones would be associated with RV morphology in a large cohort free of cardiovascular disease. Methods: Sex hormones were measured by immunoassay and RV ejection fraction (RVEF), stroke volume (RVSV), mass, end-diastolic volume, and end-systolic volume (RVESV) were measured by cardiac magnetic resonance imaging in 1,957 men and 1,738 postmenopausal women. The relationship between each hormone and RV parameter was assessed by multivariate linear regression. Measurements and Main Results: Higher estradiol levels were associated with higher RVEF (β per 1 ln[nmol/L], 0.88; 95% confidence interval [CI], 0.32 to 1.43; P = 0.002) and lower RVESV (β per 1 ln[nmol/L], -0.87; 95% CI, -1.67 to 20.08; P = 0.03) in women using hormone therapy. In men, higher bioavailable testosterone levels were associated with higher RVSV (β per 1 ln[nmol/L], 1.97; 95% CI, 0.20 to 3.73; P = 0.03) and greater RV mass and volumes (P ≤ 0.01). Higher dehydroepiandrosterone levels were associated with higher RVSV (β per 1 ln[nmol/L], 1.37; 95% CI, 0.15 to 2.59; P = 0.03) and greater RV mass (β per 1 ln[nmol/L], 0.25; 95% CI, 0.00 to 0.49; P = 0.05) and volumes (P ≤ 0.001) in women. Conclusions: Higher estradiol levels were associated with better RV systolic function in women using hormone therapy. Higher levels of androgens were associated with greater RV mass and volumes in both sexes.
AB - Rationale: Sex hormones have effects on the left ventricle, but hormonal influences on the right ventricle (RV) are unknown. Objectives: We hypothesized that sex hormones would be associated with RV morphology in a large cohort free of cardiovascular disease. Methods: Sex hormones were measured by immunoassay and RV ejection fraction (RVEF), stroke volume (RVSV), mass, end-diastolic volume, and end-systolic volume (RVESV) were measured by cardiac magnetic resonance imaging in 1,957 men and 1,738 postmenopausal women. The relationship between each hormone and RV parameter was assessed by multivariate linear regression. Measurements and Main Results: Higher estradiol levels were associated with higher RVEF (β per 1 ln[nmol/L], 0.88; 95% confidence interval [CI], 0.32 to 1.43; P = 0.002) and lower RVESV (β per 1 ln[nmol/L], -0.87; 95% CI, -1.67 to 20.08; P = 0.03) in women using hormone therapy. In men, higher bioavailable testosterone levels were associated with higher RVSV (β per 1 ln[nmol/L], 1.97; 95% CI, 0.20 to 3.73; P = 0.03) and greater RV mass and volumes (P ≤ 0.01). Higher dehydroepiandrosterone levels were associated with higher RVSV (β per 1 ln[nmol/L], 1.37; 95% CI, 0.15 to 2.59; P = 0.03) and greater RV mass (β per 1 ln[nmol/L], 0.25; 95% CI, 0.00 to 0.49; P = 0.05) and volumes (P ≤ 0.001) in women. Conclusions: Higher estradiol levels were associated with better RV systolic function in women using hormone therapy. Higher levels of androgens were associated with greater RV mass and volumes in both sexes.
KW - Right ventricle
KW - Sex
KW - Sex hormones
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U2 - 10.1164/rccm.201007-1027OC
DO - 10.1164/rccm.201007-1027OC
M3 - Article
C2 - 20889903
AN - SCOPUS:79952209415
SN - 1073-449X
VL - 183
SP - 659
EP - 667
JO - American journal of respiratory and critical care medicine
JF - American journal of respiratory and critical care medicine
IS - 5
ER -