Sex, epilepsy, and epigenetics

Irfan A. Qureshi, Mark F. Mehler

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Epilepsy refers to a heterogeneous group of disorders that are associated with a wide range of pathogenic mechanisms, seizure manifestations, comorbidity profiles, and therapeutic responses. These characteristics are all influenced quite significantly by sex. As with other conditions exhibiting such patterns, sex differences in epilepsy are thought to arise-at the most fundamental level-from the "organizational" and "activational" effects of sex hormones as well as from the direct actions of the sex chromosomes. However, our understanding of the specific molecular, cellular, and network level processes responsible for mediating sex differences in epilepsy remains limited. Because increasing evidence suggests that epigenetic mechanisms are involved both in epilepsy and in brain sexual dimorphism, we make the case here that analyzing epigenetic regulation will provide novel insights into the basis for sex differences in epilepsy.

Original languageEnglish (US)
Pages (from-to)210-216
Number of pages7
JournalNeurobiology of Disease
Volume72
Issue numberPB
DOIs
StatePublished - Dec 1 2014

Keywords

  • Chromatin
  • DNA methylation
  • Epigenetic
  • Epilepsy
  • Histone
  • Non-coding RNA

ASJC Scopus subject areas

  • Neurology

Fingerprint Dive into the research topics of 'Sex, epilepsy, and epigenetics'. Together they form a unique fingerprint.

Cite this