Sex Differences in Acute Kidney Injury

Joel Neugarten; Ladan Golestaneh

doi:10.1016/j.semnephrol.2022.04.010

Sex Differences in Acute Kidney Injury

Joel Neugarten, Ladan Golestaneh

Medicine

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Female sex confers renoprotection in chronic progressive kidney disease. It is less well recognized that sexual dimorphism also is evident in the development of ischemic and nephrotoxic acute kidney injury (AKI). Animal studies consistently have shown that female sex protects against the development of renal injury in experimental models of ischemic AKI. However, the consensus opinion is that in human beings, female sex is an independent risk factor for AKI. Based on a systematic review of experimental and clinical literature, we present data to support the conclusion that, contrary to consensus opinion, it is male sex, not female sex, that is associated with the development of AKI.

Original language	English (US)
Pages (from-to)	208-218
Number of pages	11
Journal	Seminars in Nephrology
Volume	42
Issue number	2
DOIs	https://doi.org/10.1016/j.semnephrol.2022.04.010
State	Published - Mar 2022

Keywords

AKI
Sex
estrogen
gender
testosterone

ASJC Scopus subject areas

Nephrology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.semnephrol.2022.04.010

Cite this

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title = "Sex Differences in Acute Kidney Injury",

abstract = "Female sex confers renoprotection in chronic progressive kidney disease. It is less well recognized that sexual dimorphism also is evident in the development of ischemic and nephrotoxic acute kidney injury (AKI). Animal studies consistently have shown that female sex protects against the development of renal injury in experimental models of ischemic AKI. However, the consensus opinion is that in human beings, female sex is an independent risk factor for AKI. Based on a systematic review of experimental and clinical literature, we present data to support the conclusion that, contrary to consensus opinion, it is male sex, not female sex, that is associated with the development of AKI.",

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AU - Neugarten, Joel

AU - Golestaneh, Ladan

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AB - Female sex confers renoprotection in chronic progressive kidney disease. It is less well recognized that sexual dimorphism also is evident in the development of ischemic and nephrotoxic acute kidney injury (AKI). Animal studies consistently have shown that female sex protects against the development of renal injury in experimental models of ischemic AKI. However, the consensus opinion is that in human beings, female sex is an independent risk factor for AKI. Based on a systematic review of experimental and clinical literature, we present data to support the conclusion that, contrary to consensus opinion, it is male sex, not female sex, that is associated with the development of AKI.

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KW - Sex

KW - estrogen

KW - gender

KW - testosterone

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Sex Differences in Acute Kidney Injury

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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