Sex and autoantibody titers determine the development of neuropsychiatric manifestations in lupus-prone mice

Hua Xin Gao, Elena Sanders, Arlene Tan Tieng, Chaim Putterman

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Emotional disturbances are among the most common neuropsychiatric manifestations of SLE, a systemic autoimmune disease with a strong female predominance. In this study, we evaluated young MRL/lpr mice, directly comparing males and females. MRL/lpr females exhibited significant depression as early as 5. weeks (at which time elevated levels of autoantibodies were already present), as compared to MRL/lpr males, where depression was noted only at 18. weeks. Depression was significantly correlated with autoantibodies against nuclear antigens, NMDA receptor, and ribosomal P. Our results are consistent with a primary role of autoantibodies in the pathogenesis of early neuropsychiatric deficits in this lupus model, which translate into gender-based differences in clinical phenotype.

Original languageEnglish (US)
Pages (from-to)112-122
Number of pages11
JournalJournal of Neuroimmunology
Volume229
Issue number1-2
DOIs
StatePublished - Dec 15 2010

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Keywords

  • Autoantibodies
  • Depression
  • Neuropsychiatric lupus
  • Sex difference

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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