Severe vaso-occlusive episodes associated with use of systemic corticosteroids in patients with sickle cell disease

Deepika S. Darbari; Oswaldo Castro; James G. Taylor VI; Ross Fasano; Jeffrey Rehm; Victor R. Gordeuk; Caterina P. Minniti

doi:10.1016/S0027-9684(15)31410-3

Severe vaso-occlusive episodes associated with use of systemic corticosteroids in patients with sickle cell disease

Deepika S. Darbari, Oswaldo Castro, James G. Taylor VI, Ross Fasano, Jeffrey Rehm, Victor R. Gordeuk, Caterina P. Minniti

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Patients with sickle cell disease (SCD) are occasionally prescribed systemic corticosteroids to treat steroid-responsive conditions. Additionally, use of systemic corticosteroids for sickle cell pain episodes and acute chest syndrome is under investigation. We report 4 patients with SCD who developed severe vaso-occlusive events following the administration of systemic steroids. We also review similar cases from the literature and suggest measures for reducing the potential risk associated with use of systemic corticosteroids in this group of patients. We conclude that corticosteroids should be used with caution in patients with SCD.

Original language	English (US)
Pages (from-to)	948-951
Number of pages	4
Journal	Journal of the National Medical Association
Volume	100
Issue number	8
DOIs	https://doi.org/10.1016/S0027-9684(15)31410-3
State	Published - Aug 2008
Externally published	Yes

Keywords

Adverse events
Bone
Corticosteroids
Sickle cell anemia
Vaso-occlusion

ASJC Scopus subject areas

Medicine(all)

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10.1016/S0027-9684(15)31410-3

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@article{2522123a09cf41aa8b81644219aea008,

title = "Severe vaso-occlusive episodes associated with use of systemic corticosteroids in patients with sickle cell disease",

abstract = "Patients with sickle cell disease (SCD) are occasionally prescribed systemic corticosteroids to treat steroid-responsive conditions. Additionally, use of systemic corticosteroids for sickle cell pain episodes and acute chest syndrome is under investigation. We report 4 patients with SCD who developed severe vaso-occlusive events following the administration of systemic steroids. We also review similar cases from the literature and suggest measures for reducing the potential risk associated with use of systemic corticosteroids in this group of patients. We conclude that corticosteroids should be used with caution in patients with SCD.",

keywords = "Adverse events, Bone, Corticosteroids, Sickle cell anemia, Vaso-occlusion",

author = "Darbari, {Deepika S.} and Oswaldo Castro and {Taylor VI}, {James G.} and Ross Fasano and Jeffrey Rehm and Gordeuk, {Victor R.} and Minniti, {Caterina P.}",

note = "Funding Information: Financial support: This work was supported in part by contract grants #K12RR17613 and #2MOIRR10284-10 from National Center for Research Resources and #2 R25 HL003679-08 and #1 R01 HL079912-02 from National Heart, Lung and Blood Institute, National Institutes of Health (NIH), Bethesda, MD, and by the intramural research program of NIH.",

year = "2008",

month = aug,

doi = "10.1016/S0027-9684(15)31410-3",

language = "English (US)",

volume = "100",

pages = "948--951",

journal = "Journal of the National Medical Association",

issn = "1943-4693",

publisher = "National Medical Association",

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TY - JOUR

T1 - Severe vaso-occlusive episodes associated with use of systemic corticosteroids in patients with sickle cell disease

AU - Darbari, Deepika S.

AU - Castro, Oswaldo

AU - Taylor VI, James G.

AU - Fasano, Ross

AU - Rehm, Jeffrey

AU - Gordeuk, Victor R.

AU - Minniti, Caterina P.

N1 - Funding Information: Financial support: This work was supported in part by contract grants #K12RR17613 and #2MOIRR10284-10 from National Center for Research Resources and #2 R25 HL003679-08 and #1 R01 HL079912-02 from National Heart, Lung and Blood Institute, National Institutes of Health (NIH), Bethesda, MD, and by the intramural research program of NIH.

PY - 2008/8

Y1 - 2008/8

N2 - Patients with sickle cell disease (SCD) are occasionally prescribed systemic corticosteroids to treat steroid-responsive conditions. Additionally, use of systemic corticosteroids for sickle cell pain episodes and acute chest syndrome is under investigation. We report 4 patients with SCD who developed severe vaso-occlusive events following the administration of systemic steroids. We also review similar cases from the literature and suggest measures for reducing the potential risk associated with use of systemic corticosteroids in this group of patients. We conclude that corticosteroids should be used with caution in patients with SCD.

AB - Patients with sickle cell disease (SCD) are occasionally prescribed systemic corticosteroids to treat steroid-responsive conditions. Additionally, use of systemic corticosteroids for sickle cell pain episodes and acute chest syndrome is under investigation. We report 4 patients with SCD who developed severe vaso-occlusive events following the administration of systemic steroids. We also review similar cases from the literature and suggest measures for reducing the potential risk associated with use of systemic corticosteroids in this group of patients. We conclude that corticosteroids should be used with caution in patients with SCD.

KW - Adverse events

KW - Bone

KW - Corticosteroids

KW - Sickle cell anemia

KW - Vaso-occlusion

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DO - 10.1016/S0027-9684(15)31410-3

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AN - SCOPUS:50049106076

SN - 1943-4693

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SP - 948

EP - 951

JO - Journal of the National Medical Association

JF - Journal of the National Medical Association

IS - 8

ER -

Severe vaso-occlusive episodes associated with use of systemic corticosteroids in patients with sickle cell disease

Abstract

Keywords

ASJC Scopus subject areas

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