Severe vaso-occlusive episodes associated with use of systemic corticosteroids in patients with sickle cell disease

Deepika S. Darbari, Oswaldo Castro, James G. Taylor VI, Ross Fasano, Jeffrey Rehm, Victor R. Gordeuk, Caterina P. Minniti

Research output: Contribution to journalArticle

39 Scopus citations


Patients with sickle cell disease (SCD) are occasionally prescribed systemic corticosteroids to treat steroid-responsive conditions. Additionally, use of systemic corticosteroids for sickle cell pain episodes and acute chest syndrome is under investigation. We report 4 patients with SCD who developed severe vaso-occlusive events following the administration of systemic steroids. We also review similar cases from the literature and suggest measures for reducing the potential risk associated with use of systemic corticosteroids in this group of patients. We conclude that corticosteroids should be used with caution in patients with SCD.

Original languageEnglish (US)
Pages (from-to)948-951
Number of pages4
JournalJournal of the National Medical Association
Issue number8
StatePublished - Aug 2008



  • Adverse events
  • Bone
  • Corticosteroids
  • Sickle cell anemia
  • Vaso-occlusion

ASJC Scopus subject areas

  • Medicine(all)

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