Severe vaso-occlusive episodes associated with use of systemic corticosteroids in patients with sickle cell disease

Deepika S. Darbari, Oswaldo Castro, James G. Taylor VI, Ross Fasano, Jeffrey Rehm, Victor R. Gordeuk, Caterina P. Minniti

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Patients with sickle cell disease (SCD) are occasionally prescribed systemic corticosteroids to treat steroid-responsive conditions. Additionally, use of systemic corticosteroids for sickle cell pain episodes and acute chest syndrome is under investigation. We report 4 patients with SCD who developed severe vaso-occlusive events following the administration of systemic steroids. We also review similar cases from the literature and suggest measures for reducing the potential risk associated with use of systemic corticosteroids in this group of patients. We conclude that corticosteroids should be used with caution in patients with SCD.

Original languageEnglish (US)
Pages (from-to)948-951
Number of pages4
JournalJournal of the National Medical Association
Volume100
Issue number8
StatePublished - Aug 2008
Externally publishedYes

Fingerprint

Sickle Cell Anemia
Adrenal Cortex Hormones
Acute Chest Syndrome
Steroids
Pain

Keywords

  • Adverse events
  • Bone
  • Corticosteroids
  • Sickle cell anemia
  • Vaso-occlusion

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Severe vaso-occlusive episodes associated with use of systemic corticosteroids in patients with sickle cell disease. / Darbari, Deepika S.; Castro, Oswaldo; Taylor VI, James G.; Fasano, Ross; Rehm, Jeffrey; Gordeuk, Victor R.; Minniti, Caterina P.

In: Journal of the National Medical Association, Vol. 100, No. 8, 08.2008, p. 948-951.

Research output: Contribution to journalArticle

Darbari, Deepika S. ; Castro, Oswaldo ; Taylor VI, James G. ; Fasano, Ross ; Rehm, Jeffrey ; Gordeuk, Victor R. ; Minniti, Caterina P. / Severe vaso-occlusive episodes associated with use of systemic corticosteroids in patients with sickle cell disease. In: Journal of the National Medical Association. 2008 ; Vol. 100, No. 8. pp. 948-951.
@article{2522123a09cf41aa8b81644219aea008,
title = "Severe vaso-occlusive episodes associated with use of systemic corticosteroids in patients with sickle cell disease",
abstract = "Patients with sickle cell disease (SCD) are occasionally prescribed systemic corticosteroids to treat steroid-responsive conditions. Additionally, use of systemic corticosteroids for sickle cell pain episodes and acute chest syndrome is under investigation. We report 4 patients with SCD who developed severe vaso-occlusive events following the administration of systemic steroids. We also review similar cases from the literature and suggest measures for reducing the potential risk associated with use of systemic corticosteroids in this group of patients. We conclude that corticosteroids should be used with caution in patients with SCD.",
keywords = "Adverse events, Bone, Corticosteroids, Sickle cell anemia, Vaso-occlusion",
author = "Darbari, {Deepika S.} and Oswaldo Castro and {Taylor VI}, {James G.} and Ross Fasano and Jeffrey Rehm and Gordeuk, {Victor R.} and Minniti, {Caterina P.}",
year = "2008",
month = "8",
language = "English (US)",
volume = "100",
pages = "948--951",
journal = "Journal of the National Medical Association",
issn = "1943-4693",
publisher = "National Medical Association",
number = "8",

}

TY - JOUR

T1 - Severe vaso-occlusive episodes associated with use of systemic corticosteroids in patients with sickle cell disease

AU - Darbari, Deepika S.

AU - Castro, Oswaldo

AU - Taylor VI, James G.

AU - Fasano, Ross

AU - Rehm, Jeffrey

AU - Gordeuk, Victor R.

AU - Minniti, Caterina P.

PY - 2008/8

Y1 - 2008/8

N2 - Patients with sickle cell disease (SCD) are occasionally prescribed systemic corticosteroids to treat steroid-responsive conditions. Additionally, use of systemic corticosteroids for sickle cell pain episodes and acute chest syndrome is under investigation. We report 4 patients with SCD who developed severe vaso-occlusive events following the administration of systemic steroids. We also review similar cases from the literature and suggest measures for reducing the potential risk associated with use of systemic corticosteroids in this group of patients. We conclude that corticosteroids should be used with caution in patients with SCD.

AB - Patients with sickle cell disease (SCD) are occasionally prescribed systemic corticosteroids to treat steroid-responsive conditions. Additionally, use of systemic corticosteroids for sickle cell pain episodes and acute chest syndrome is under investigation. We report 4 patients with SCD who developed severe vaso-occlusive events following the administration of systemic steroids. We also review similar cases from the literature and suggest measures for reducing the potential risk associated with use of systemic corticosteroids in this group of patients. We conclude that corticosteroids should be used with caution in patients with SCD.

KW - Adverse events

KW - Bone

KW - Corticosteroids

KW - Sickle cell anemia

KW - Vaso-occlusion

UR - http://www.scopus.com/inward/record.url?scp=50049106076&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=50049106076&partnerID=8YFLogxK

M3 - Article

C2 - 18717146

AN - SCOPUS:50049106076

VL - 100

SP - 948

EP - 951

JO - Journal of the National Medical Association

JF - Journal of the National Medical Association

SN - 1943-4693

IS - 8

ER -