TY - JOUR
T1 - Severe Mental Illness and Cardiovascular Disease
T2 - JACC State-of-the-Art Review
AU - Goldfarb, Michael
AU - De Hert, Marc
AU - Detraux, Johan
AU - Di Palo, Katherine
AU - Munir, Haroon
AU - Music, Sanela
AU - Piña, Ileana
AU - Ringen, Petter Andreas
N1 - Publisher Copyright:
© 2022 American College of Cardiology Foundation
PY - 2022/8/30
Y1 - 2022/8/30
N2 - People with severe mental illness, consisting of schizophrenia, bipolar disorder, and major depression, have a high burden of modifiable cardiovascular risk behaviors and conditions and have a cardiovascular mortality rate twice that of the general population. People with acute and chronic cardiovascular disease are at a higher risk of developing mental health symptoms and disease. There is emerging evidence for shared etiological factors between severe mental illness and cardiovascular disease that includes biological, genetic, and behavioral mechanisms. This state-of-the art review will describe the relationship between severe mental illness and cardiovascular disease, explore the factors that lead to poor cardiovascular outcomes in people with severe mental illness, propose strategies to improve the cardiovascular health of people with severe mental illness, and present areas for future research focus.
AB - People with severe mental illness, consisting of schizophrenia, bipolar disorder, and major depression, have a high burden of modifiable cardiovascular risk behaviors and conditions and have a cardiovascular mortality rate twice that of the general population. People with acute and chronic cardiovascular disease are at a higher risk of developing mental health symptoms and disease. There is emerging evidence for shared etiological factors between severe mental illness and cardiovascular disease that includes biological, genetic, and behavioral mechanisms. This state-of-the art review will describe the relationship between severe mental illness and cardiovascular disease, explore the factors that lead to poor cardiovascular outcomes in people with severe mental illness, propose strategies to improve the cardiovascular health of people with severe mental illness, and present areas for future research focus.
KW - cardio-metabolic
KW - cardiovascular disease
KW - mental illness
KW - risk factors
UR - http://www.scopus.com/inward/record.url?scp=85135863379&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85135863379&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2022.06.017
DO - 10.1016/j.jacc.2022.06.017
M3 - Review article
C2 - 36007991
AN - SCOPUS:85135863379
SN - 0735-1097
VL - 80
SP - 918
EP - 933
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 9
ER -