Severe liver injury after treatment with the leukotriene receptor antagonist zafirlukast

J. F. Reinus, S. Persky, J. S. Burkiewicz, D. Quan, N. M. Bass, T. J. Davern

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Background: In registration trials, zafirlukast, an asthma medication, caused asymptomatic elevated aminotransferase levels in up to 5% of participants. Until now, however, no cases of severe hepatitis attributed to zafirlukast have been reported. Objective: To report the clinical characteristics of three patients with severe hepatitis due to zafirlukast. Design: Case report. Setting: One community hospital and two university hospitals. Patients: Three middle-aged women taking zafirlukast, 20 mg twice per day. Intervention: Discontinuation of zafirlukast therapy in three patients, steroid therapy in two patients, and orthotopic liver transplantation in one patient. Measurements: Serum aminotransferase and bilirubin levels, standard blood tests for causes of hepatitis other than drug toxicity, and liver biopsy in two patients. Results: Patient 1 recovered spontaneously, had a severe relapse after inadvertent rechallenge with the medication, and ultimately made a complete recovery. Patient 2 developed subfulminant hepatic failure and required liver transplantation. Patient 3 developed severe hepatitis that improved after treatment with corticosteroids. Liver tissue was available from two patients and showed histologic changes commonly associated with drug reactions. Conclusion: Patients receiving zafirlukast may develop severe liver injury and should be observed for signs and symptoms of hepatitis.

Original languageEnglish (US)
Pages (from-to)964-968
Number of pages5
JournalAnnals of internal medicine
Volume133
Issue number12
DOIs
StatePublished - Dec 19 2000

ASJC Scopus subject areas

  • Internal Medicine

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