Severe asthma with fungal sensitization in a child: Response to itraconazole therapy

Alfin G. Vicencio, Hiren Muzumdar, Kalliope Tsirilakis, Aaron Kessel, Kiran Nandalike, David L. Goldman

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

People with severe asthma with fungal sensitization may represent an underdiagnosed subset of patients with refractory disease. It is important to know that such patients may benefit from adjunct treatment with antifungal agents. We describe here the case of a child with refractory asthma, persistent airway obstruction, a serum immunoglobulin E level of >20 000 IU/mL, and severe eosinophilic airway infiltration. Although he did not meet diagnostic criteria for allergic bronchopulmonary aspergillosis, he demonstrated evidence of sensitization to several fungi and responded dramatically to the addition of itraconazole therapy. We also discuss emerging hypotheses regarding fungal-induced asthma.

Original languageEnglish (US)
JournalPediatrics
Volume125
Issue number5
DOIs
StatePublished - May 2010

Fingerprint

Itraconazole
Asthma
Allergic Bronchopulmonary Aspergillosis
Antifungal Agents
Airway Obstruction
Immunoglobulin E
Fungi
Therapeutics
Serum

Keywords

  • Airway
  • Fungal
  • Inflammation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Severe asthma with fungal sensitization in a child : Response to itraconazole therapy. / Vicencio, Alfin G.; Muzumdar, Hiren; Tsirilakis, Kalliope; Kessel, Aaron; Nandalike, Kiran; Goldman, David L.

In: Pediatrics, Vol. 125, No. 5, 05.2010.

Research output: Contribution to journalArticle

Vicencio, Alfin G. ; Muzumdar, Hiren ; Tsirilakis, Kalliope ; Kessel, Aaron ; Nandalike, Kiran ; Goldman, David L. / Severe asthma with fungal sensitization in a child : Response to itraconazole therapy. In: Pediatrics. 2010 ; Vol. 125, No. 5.
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