Serum total bilirubin and long-term outcome in patients undergoing percutaneous coronary intervention

Xiao Juan Zhang, Tong Wen Sun, Quan Cheng Kan, Hai Mu Yao, You Dong Wan, Rui Yao, Fang Xia Guan, Chang Qing Guo, Shu Guang Zhang, Wen Ju Sun, Le Xin Wang

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3 Scopus citations

Abstract

Purpose: The purpose of this study was to investigate the associated between serum total bilirubin (STB) levels and long-term outcomes in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI). Methods: A total of 1,273 consecutive patients were enrolled. Patients were grouped according to their baseline STB levels: Group 1 (STB < 3.4 μmol/L), Group 2 (3.4 μmol/L ≤ STB ≤ 10.3 μmol/L), Group 3 (10.3 μmol/L < STB ≤ 17.1 μmol/L), and Group 4 (STB > 17.1 μmol/L) and the rate of major adverse cardiovascular events (MACE) was determined Results: A total of 1,152 patients were successfully followed up (90.5%) for a mean period of 30 ± 5 months, including 187 patients experiencing a major adverse cardiovascular event (MACE: death from any cause, myocardial infarction, repeat revascularization or readmission). The MACE rate in Groups 3 and 4 was lower than in Groups 1 and 2 (P < 0.01). After adjusted the confounding factors with Cox regression analysis, the MACE rates in Groups 2-4 were still lower than in Group 1 (Group 2, RR=0.293, 95% CI 0.167-0.517, P<0.01; Group 3, RR=0.142, 95% CI 0.065-0.312, P<0.01; Group 4, RR=0.134, 95% CI 0.071-0.252, P<0.01). The cumulative survival rates of Groups 3 and 4 were higher than that of Groups 1and 2 (P<0.01). Conclusions: High STB concentration is associated with lower MACE in patients with ACS after PCI.

Original languageEnglish (US)
Pages (from-to)E345-E351
JournalClinical and Investigative Medicine
Volume37
Issue number5
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Medicine(all)

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    Zhang, X. J., Sun, T. W., Kan, Q. C., Yao, H. M., Wan, Y. D., Yao, R., Guan, F. X., Guo, C. Q., Zhang, S. G., Sun, W. J., & Wang, L. X. (2014). Serum total bilirubin and long-term outcome in patients undergoing percutaneous coronary intervention. Clinical and Investigative Medicine, 37(5), E345-E351.