Serum phosphate levels and risk of infection in incident dialysis patients

Laura C. Plantinga, Nancy E. Fink, Michal L. Melamed, William A. Briggs, Neil R. Powe, Bernard G. Jaar

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background and objectives: Hyperphosphatemia is highly prevalent in dialysis patients and may be associated with immune dysfunction. The association of serum phosphate level with infection remains largely unexamined. Design, setting, participants, & measurements: In an incident cohort of 1010 dialysis patients enrolled from 1995 to 1998 and treated in 80 US clinics, the association of phosphate level (low < 3.5; normal 3.5 to 5.5; high > 5.5 mg/dl) at baseline and during follow-up with the risk for incident inpatient and outpatient infection-related events was examined. Infectious events were identified from US Renal Data System data (mean follow-up 3.3 yr). Incidence rate ratios for all infections, sepsis, respiratory tract infections, and osteomyelitis were obtained using multivariable Poisson models, adjusting for potential confounders (age, race, gender, smoking, comorbidity, and laboratory values). Results: Infections of any type (n = 1398) were more frequent among patients with high phosphate levels at baseline, relative to normal; this association was not changed by adjustment for parathyroid hormone level. Similarly, high versus normal baseline phosphate was associated with increased risk for sepsis and osteomyelitis but not respiratory tract infections. Associations with calcium were generally NS, and results with calcium-phosphate product mirrored the phosphate results. Conclusions: High phosphate levels may be associated with increased risk for infection, contributing further to the rationale for aggressive management of hyperphosphatemia in dialysis patients.

Original languageEnglish (US)
Pages (from-to)1398-1406
Number of pages9
JournalClinical Journal of the American Society of Nephrology
Volume3
Issue number5
DOIs
StatePublished - Sep 2008

Fingerprint

Dialysis
Phosphates
Infection
Serum
Hyperphosphatemia
Osteomyelitis
Respiratory Tract Infections
Sepsis
Parathyroid Hormone
Information Systems
Comorbidity
Inpatients
Outpatients
Smoking
Calcium
Kidney
Incidence

ASJC Scopus subject areas

  • Nephrology
  • Transplantation
  • Epidemiology
  • Critical Care and Intensive Care Medicine

Cite this

Serum phosphate levels and risk of infection in incident dialysis patients. / Plantinga, Laura C.; Fink, Nancy E.; Melamed, Michal L.; Briggs, William A.; Powe, Neil R.; Jaar, Bernard G.

In: Clinical Journal of the American Society of Nephrology, Vol. 3, No. 5, 09.2008, p. 1398-1406.

Research output: Contribution to journalArticle

Plantinga, Laura C. ; Fink, Nancy E. ; Melamed, Michal L. ; Briggs, William A. ; Powe, Neil R. ; Jaar, Bernard G. / Serum phosphate levels and risk of infection in incident dialysis patients. In: Clinical Journal of the American Society of Nephrology. 2008 ; Vol. 3, No. 5. pp. 1398-1406.
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