Serum folate receptor α (sFR) in ovarian cancer diagnosis and surveillance

Batoul Farran, Samet Albayrak, Judith Abrams, Michael A. Tainsky, Nancy K. Levin, Robert Morris, Larry H. Matherly, Manohar Ratnam, Ira Winer

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Novelty and Impact Statement: Our findings suggest that soluble folate receptor (sFR) could be used in both the initial diagnosis and surveillance of patients with ovarian cancer. Our cohort constitutes one of the largest comparison groups for sFR analyzed so far. We have defined the background level of sFR using healthy volunteers. This is also the first study to prospectively follow patients in the surveillance setting to concurrently identify differential changes in tumor markers CA-125 and sFR.

Original languageEnglish (US)
Pages (from-to)920-927
Number of pages8
JournalCancer Medicine
Volume8
Issue number3
DOIs
StatePublished - Mar 2019
Externally publishedYes

Keywords

  • biomarkers
  • gynecologic oncology
  • translational research

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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