Serum Complement ‘Supergenes' of the Major Histocompatibility Complex in Man (Complotypes)

Chester A. Alper; Donald Raum; Sharon Karp; Zuheir L. Awdeh; Edmond J. Yunis

doi:10.1111/j.1423-0410.1983.tb04124.x

Serum Complement ‘Supergenes' of the Major Histocompatibility Complex in Man (Complotypes)

Chester A. Alper, Donald Raum, Sharon Karp, Zuheir L. Awdeh, Edmond J. Yunis

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

Abstract. The loci for the complement proteins C2 and BF, and the two loci for C4 arc closely linked to one another. In many hundreds of meioses no crossing over has been detected between these loci. In addition, the alleles of these four loci occur in specific combinations not predicted by their gene frequencies in much the same way as alleles of the Rh and MNS systems. These units are termed complotypes. There are 14 complotypes with frequencies in excess of 1% in our study population of normal sixth chromosomes from Caucasians. Since they are also intimately associated with HLA‐DR, complotypes may also be of importance in screening programs for transplantation.

Original language	English (US)
Pages (from-to)	62-67
Number of pages	6
Journal	Vox Sanguinis
Volume	45
Issue number	1
DOIs	https://doi.org/10.1111/j.1423-0410.1983.tb04124.x
State	Published - Jul 1983
Externally published	Yes

ASJC Scopus subject areas

Hematology

Access to Document

10.1111/j.1423-0410.1983.tb04124.x

Cite this

@article{b58cf9da849645daa3913a6f9ce79bc3,

title = "Serum Complement {\textquoteleft}Supergenes' of the Major Histocompatibility Complex in Man (Complotypes)",

abstract = "Abstract. The loci for the complement proteins C2 and BF, and the two loci for C4 arc closely linked to one another. In many hundreds of meioses no crossing over has been detected between these loci. In addition, the alleles of these four loci occur in specific combinations not predicted by their gene frequencies in much the same way as alleles of the Rh and MNS systems. These units are termed complotypes. There are 14 complotypes with frequencies in excess of 1% in our study population of normal sixth chromosomes from Caucasians. Since they are also intimately associated with HLA‐DR, complotypes may also be of importance in screening programs for transplantation.",

author = "Alper, {Chester A.} and Donald Raum and Sharon Karp and Awdeh, {Zuheir L.} and Yunis, {Edmond J.}",

year = "1983",

month = jul,

doi = "10.1111/j.1423-0410.1983.tb04124.x",

language = "English (US)",

volume = "45",

pages = "62--67",

journal = "Vox Sanguinis",

issn = "0042-9007",

publisher = "Wiley-Blackwell",

number = "1",

}

TY - JOUR

T1 - Serum Complement ‘Supergenes' of the Major Histocompatibility Complex in Man (Complotypes)

AU - Alper, Chester A.

AU - Raum, Donald

AU - Karp, Sharon

AU - Awdeh, Zuheir L.

AU - Yunis, Edmond J.

PY - 1983/7

Y1 - 1983/7

N2 - Abstract. The loci for the complement proteins C2 and BF, and the two loci for C4 arc closely linked to one another. In many hundreds of meioses no crossing over has been detected between these loci. In addition, the alleles of these four loci occur in specific combinations not predicted by their gene frequencies in much the same way as alleles of the Rh and MNS systems. These units are termed complotypes. There are 14 complotypes with frequencies in excess of 1% in our study population of normal sixth chromosomes from Caucasians. Since they are also intimately associated with HLA‐DR, complotypes may also be of importance in screening programs for transplantation.

AB - Abstract. The loci for the complement proteins C2 and BF, and the two loci for C4 arc closely linked to one another. In many hundreds of meioses no crossing over has been detected between these loci. In addition, the alleles of these four loci occur in specific combinations not predicted by their gene frequencies in much the same way as alleles of the Rh and MNS systems. These units are termed complotypes. There are 14 complotypes with frequencies in excess of 1% in our study population of normal sixth chromosomes from Caucasians. Since they are also intimately associated with HLA‐DR, complotypes may also be of importance in screening programs for transplantation.

UR - http://www.scopus.com/inward/record.url?scp=0020531266&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020531266&partnerID=8YFLogxK

U2 - 10.1111/j.1423-0410.1983.tb04124.x

DO - 10.1111/j.1423-0410.1983.tb04124.x

M3 - Article

C2 - 6554026

AN - SCOPUS:0020531266

SN - 0042-9007

VL - 45

SP - 62

EP - 67

JO - Vox Sanguinis

JF - Vox Sanguinis

IS - 1

ER -

Serum Complement ‘Supergenes' of the Major Histocompatibility Complex in Man (Complotypes)

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this