Serum complement 'supergenes' of the major histocompatibility complex in man (complotypes)

C. A. Alper, Donald Douglas Raum, S. Karp, Z. L. Awdeh, E. J. Yunis

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

The loci for the complement proteins C2 and Bf, and the two loci for C4 are closely linked to one another. In many hundreds of meioses no crossing over has been detected between these loci. In addition, the alleles of these four loci occur in specific combinations not predicted by their gene frequencies in much the same way as alleles of the Rh and MNS systems. These units are termed complotypes. There are 14 complotypes with frequencies in excess of 1% in our study population of normal sixth chromosomes from Caucasians. Since they are also intimately associated with HLA-DR, complotypes may also be of importance in screening programs for transplantation.

Original languageEnglish (US)
Pages (from-to)62-67
Number of pages6
JournalVox Sanguinis
Volume45
Issue number1
StatePublished - 1983
Externally publishedYes

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Major Histocompatibility Complex
Complement C2
Alleles
Meiosis
HLA-DR Antigens
Serum
Gene Frequency
Complement System Proteins
Chromosomes
Transplantation
Population

ASJC Scopus subject areas

  • Hematology

Cite this

Alper, C. A., Raum, D. D., Karp, S., Awdeh, Z. L., & Yunis, E. J. (1983). Serum complement 'supergenes' of the major histocompatibility complex in man (complotypes). Vox Sanguinis, 45(1), 62-67.

Serum complement 'supergenes' of the major histocompatibility complex in man (complotypes). / Alper, C. A.; Raum, Donald Douglas; Karp, S.; Awdeh, Z. L.; Yunis, E. J.

In: Vox Sanguinis, Vol. 45, No. 1, 1983, p. 62-67.

Research output: Contribution to journalArticle

Alper, CA, Raum, DD, Karp, S, Awdeh, ZL & Yunis, EJ 1983, 'Serum complement 'supergenes' of the major histocompatibility complex in man (complotypes)', Vox Sanguinis, vol. 45, no. 1, pp. 62-67.
Alper, C. A. ; Raum, Donald Douglas ; Karp, S. ; Awdeh, Z. L. ; Yunis, E. J. / Serum complement 'supergenes' of the major histocompatibility complex in man (complotypes). In: Vox Sanguinis. 1983 ; Vol. 45, No. 1. pp. 62-67.
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