Serum bicarbonate and bone mineral density in US adults

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background Chronic metabolic acidosis leads to bone mineral loss and results in lower bone mineral density (BMD), which is a risk factor for osteoporosis-related fractures. The effect of low-level metabolic acidosis on bone density in the general population is unknown. Study Design Cross-sectional study. Setting & Participants 9,724 nationally representative adults 20 years or older in NHANES (National Health and Nutrition Examination Survey) 1999-2004. Factor Serum bicarbonate level. Outcomes Lumbar and total BMD, as well as low lumbar and total bone mass, defined as 1.0 SD below the sex-specific mean value of young adults. Measurements BMD was measured by dual-energy x-ray absorptiometry and serum bicarbonate was measured in all participants. Results Both men and women with lower serum bicarbonate levels were more likely to be current smokers and had higher body mass index and estimated net endogenous acid production. There was a significant linear trend across quartiles of serum bicarbonate with lumbar BMD in the total population, as well as in sex-specific models (P = 0.02 for all 3 models, P = 0.1 for interaction). For total BMD, a significant association was seen with serum bicarbonate level for women but not men (P = 0.02 and P = 0.1, respectively; P = 0.8 for interaction), and a significant association was seen for postmenopausal women but not premenopausal women (P = 0.02 and P = 0.2, respectively; P = 0.5 for interaction). Compared with women with serum bicarbonate levels < 24 mEq/L, those with serum bicarbonate levels ≥ 27 mEq/L had 0.018-g/cm2 higher total BMD (95% CI, 0.004-0.032; P = 0.01) and 31% lower odds of having low total bone mass (OR, 0.68; 95% CI, 0.46-0.99; P = 0.049). Limitations Cross-sectional study using a single measurement of serum bicarbonate. Subgroup differences are not definitive. Conclusions Lower serum bicarbonate levels are associated with lower BMD in US adults. Further studies should examine whether serum bicarbonate levels should be incorporated into the diagnostic assessment and management of osteoporosis.

Original languageEnglish (US)
Pages (from-to)240-248
Number of pages9
JournalAmerican Journal of Kidney Diseases
Volume65
Issue number2
DOIs
StatePublished - Feb 1 2015

Fingerprint

Bicarbonates
Bone Density
Serum
Acidosis
Bone and Bones
Osteoporosis
Cross-Sectional Studies
Nutrition Surveys
Population
Minerals
Young Adult
Body Mass Index
X-Rays
Acids

Keywords

  • (NHANES)
  • absorptiometry (DEXA)
  • acidosis bone mineral density (BMD)
  • alkali
  • bone mass modifiable risk factor
  • dual-energy x-ray
  • Examination Survey
  • lumbar BMD
  • National Health and Nutrition
  • osteoporosis low
  • Serum bicarbonate
  • therapy metabolic

ASJC Scopus subject areas

  • Nephrology

Cite this

Serum bicarbonate and bone mineral density in US adults. / Chen, Wei; Melamed, Michal L.; Abramowitz, Matthew K.

In: American Journal of Kidney Diseases, Vol. 65, No. 2, 01.02.2015, p. 240-248.

Research output: Contribution to journalArticle

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title = "Serum bicarbonate and bone mineral density in US adults",
abstract = "Background Chronic metabolic acidosis leads to bone mineral loss and results in lower bone mineral density (BMD), which is a risk factor for osteoporosis-related fractures. The effect of low-level metabolic acidosis on bone density in the general population is unknown. Study Design Cross-sectional study. Setting & Participants 9,724 nationally representative adults 20 years or older in NHANES (National Health and Nutrition Examination Survey) 1999-2004. Factor Serum bicarbonate level. Outcomes Lumbar and total BMD, as well as low lumbar and total bone mass, defined as 1.0 SD below the sex-specific mean value of young adults. Measurements BMD was measured by dual-energy x-ray absorptiometry and serum bicarbonate was measured in all participants. Results Both men and women with lower serum bicarbonate levels were more likely to be current smokers and had higher body mass index and estimated net endogenous acid production. There was a significant linear trend across quartiles of serum bicarbonate with lumbar BMD in the total population, as well as in sex-specific models (P = 0.02 for all 3 models, P = 0.1 for interaction). For total BMD, a significant association was seen with serum bicarbonate level for women but not men (P = 0.02 and P = 0.1, respectively; P = 0.8 for interaction), and a significant association was seen for postmenopausal women but not premenopausal women (P = 0.02 and P = 0.2, respectively; P = 0.5 for interaction). Compared with women with serum bicarbonate levels < 24 mEq/L, those with serum bicarbonate levels ≥ 27 mEq/L had 0.018-g/cm2 higher total BMD (95{\%} CI, 0.004-0.032; P = 0.01) and 31{\%} lower odds of having low total bone mass (OR, 0.68; 95{\%} CI, 0.46-0.99; P = 0.049). Limitations Cross-sectional study using a single measurement of serum bicarbonate. Subgroup differences are not definitive. Conclusions Lower serum bicarbonate levels are associated with lower BMD in US adults. Further studies should examine whether serum bicarbonate levels should be incorporated into the diagnostic assessment and management of osteoporosis.",
keywords = "(NHANES), absorptiometry (DEXA), acidosis bone mineral density (BMD), alkali, bone mass modifiable risk factor, dual-energy x-ray, Examination Survey, lumbar BMD, National Health and Nutrition, osteoporosis low, Serum bicarbonate, therapy metabolic",
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AU - Chen, Wei

AU - Melamed, Michal L.

AU - Abramowitz, Matthew K.

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N2 - Background Chronic metabolic acidosis leads to bone mineral loss and results in lower bone mineral density (BMD), which is a risk factor for osteoporosis-related fractures. The effect of low-level metabolic acidosis on bone density in the general population is unknown. Study Design Cross-sectional study. Setting & Participants 9,724 nationally representative adults 20 years or older in NHANES (National Health and Nutrition Examination Survey) 1999-2004. Factor Serum bicarbonate level. Outcomes Lumbar and total BMD, as well as low lumbar and total bone mass, defined as 1.0 SD below the sex-specific mean value of young adults. Measurements BMD was measured by dual-energy x-ray absorptiometry and serum bicarbonate was measured in all participants. Results Both men and women with lower serum bicarbonate levels were more likely to be current smokers and had higher body mass index and estimated net endogenous acid production. There was a significant linear trend across quartiles of serum bicarbonate with lumbar BMD in the total population, as well as in sex-specific models (P = 0.02 for all 3 models, P = 0.1 for interaction). For total BMD, a significant association was seen with serum bicarbonate level for women but not men (P = 0.02 and P = 0.1, respectively; P = 0.8 for interaction), and a significant association was seen for postmenopausal women but not premenopausal women (P = 0.02 and P = 0.2, respectively; P = 0.5 for interaction). Compared with women with serum bicarbonate levels < 24 mEq/L, those with serum bicarbonate levels ≥ 27 mEq/L had 0.018-g/cm2 higher total BMD (95% CI, 0.004-0.032; P = 0.01) and 31% lower odds of having low total bone mass (OR, 0.68; 95% CI, 0.46-0.99; P = 0.049). Limitations Cross-sectional study using a single measurement of serum bicarbonate. Subgroup differences are not definitive. Conclusions Lower serum bicarbonate levels are associated with lower BMD in US adults. Further studies should examine whether serum bicarbonate levels should be incorporated into the diagnostic assessment and management of osteoporosis.

AB - Background Chronic metabolic acidosis leads to bone mineral loss and results in lower bone mineral density (BMD), which is a risk factor for osteoporosis-related fractures. The effect of low-level metabolic acidosis on bone density in the general population is unknown. Study Design Cross-sectional study. Setting & Participants 9,724 nationally representative adults 20 years or older in NHANES (National Health and Nutrition Examination Survey) 1999-2004. Factor Serum bicarbonate level. Outcomes Lumbar and total BMD, as well as low lumbar and total bone mass, defined as 1.0 SD below the sex-specific mean value of young adults. Measurements BMD was measured by dual-energy x-ray absorptiometry and serum bicarbonate was measured in all participants. Results Both men and women with lower serum bicarbonate levels were more likely to be current smokers and had higher body mass index and estimated net endogenous acid production. There was a significant linear trend across quartiles of serum bicarbonate with lumbar BMD in the total population, as well as in sex-specific models (P = 0.02 for all 3 models, P = 0.1 for interaction). For total BMD, a significant association was seen with serum bicarbonate level for women but not men (P = 0.02 and P = 0.1, respectively; P = 0.8 for interaction), and a significant association was seen for postmenopausal women but not premenopausal women (P = 0.02 and P = 0.2, respectively; P = 0.5 for interaction). Compared with women with serum bicarbonate levels < 24 mEq/L, those with serum bicarbonate levels ≥ 27 mEq/L had 0.018-g/cm2 higher total BMD (95% CI, 0.004-0.032; P = 0.01) and 31% lower odds of having low total bone mass (OR, 0.68; 95% CI, 0.46-0.99; P = 0.049). Limitations Cross-sectional study using a single measurement of serum bicarbonate. Subgroup differences are not definitive. Conclusions Lower serum bicarbonate levels are associated with lower BMD in US adults. Further studies should examine whether serum bicarbonate levels should be incorporated into the diagnostic assessment and management of osteoporosis.

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KW - bone mass modifiable risk factor

KW - dual-energy x-ray

KW - Examination Survey

KW - lumbar BMD

KW - National Health and Nutrition

KW - osteoporosis low

KW - Serum bicarbonate

KW - therapy metabolic

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