TY - JOUR
T1 - Serum bicarbonate and bone mineral density in US adults
AU - Chen, Wei
AU - Melamed, Michal L.
AU - Abramowitz, Matthew K.
N1 - Funding Information:
Support: This research was supported by American Society of Nephrology Carl W. Gottschalk Research Scholar Grants (Drs Melamed and Abramowitz), National Institutes of Health (NIH) grants U01 087783 (Drs Melamed and Abramowitz) and T32 DK007110 (Dr Chen), and Clinical and Translational Science Award grants 1 UL1 TR001073-01, 1 TL1 TR001072-01, and 1 KL2 TR001071-01 from the National Center for Advancing Translational Sciences, a component of the NIH. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.
Publisher Copyright:
© 2015 National Kidney Foundation, Inc.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Background Chronic metabolic acidosis leads to bone mineral loss and results in lower bone mineral density (BMD), which is a risk factor for osteoporosis-related fractures. The effect of low-level metabolic acidosis on bone density in the general population is unknown. Study Design Cross-sectional study. Setting & Participants 9,724 nationally representative adults 20 years or older in NHANES (National Health and Nutrition Examination Survey) 1999-2004. Factor Serum bicarbonate level. Outcomes Lumbar and total BMD, as well as low lumbar and total bone mass, defined as 1.0 SD below the sex-specific mean value of young adults. Measurements BMD was measured by dual-energy x-ray absorptiometry and serum bicarbonate was measured in all participants. Results Both men and women with lower serum bicarbonate levels were more likely to be current smokers and had higher body mass index and estimated net endogenous acid production. There was a significant linear trend across quartiles of serum bicarbonate with lumbar BMD in the total population, as well as in sex-specific models (P = 0.02 for all 3 models, P = 0.1 for interaction). For total BMD, a significant association was seen with serum bicarbonate level for women but not men (P = 0.02 and P = 0.1, respectively; P = 0.8 for interaction), and a significant association was seen for postmenopausal women but not premenopausal women (P = 0.02 and P = 0.2, respectively; P = 0.5 for interaction). Compared with women with serum bicarbonate levels < 24 mEq/L, those with serum bicarbonate levels ≥ 27 mEq/L had 0.018-g/cm2 higher total BMD (95% CI, 0.004-0.032; P = 0.01) and 31% lower odds of having low total bone mass (OR, 0.68; 95% CI, 0.46-0.99; P = 0.049). Limitations Cross-sectional study using a single measurement of serum bicarbonate. Subgroup differences are not definitive. Conclusions Lower serum bicarbonate levels are associated with lower BMD in US adults. Further studies should examine whether serum bicarbonate levels should be incorporated into the diagnostic assessment and management of osteoporosis.
AB - Background Chronic metabolic acidosis leads to bone mineral loss and results in lower bone mineral density (BMD), which is a risk factor for osteoporosis-related fractures. The effect of low-level metabolic acidosis on bone density in the general population is unknown. Study Design Cross-sectional study. Setting & Participants 9,724 nationally representative adults 20 years or older in NHANES (National Health and Nutrition Examination Survey) 1999-2004. Factor Serum bicarbonate level. Outcomes Lumbar and total BMD, as well as low lumbar and total bone mass, defined as 1.0 SD below the sex-specific mean value of young adults. Measurements BMD was measured by dual-energy x-ray absorptiometry and serum bicarbonate was measured in all participants. Results Both men and women with lower serum bicarbonate levels were more likely to be current smokers and had higher body mass index and estimated net endogenous acid production. There was a significant linear trend across quartiles of serum bicarbonate with lumbar BMD in the total population, as well as in sex-specific models (P = 0.02 for all 3 models, P = 0.1 for interaction). For total BMD, a significant association was seen with serum bicarbonate level for women but not men (P = 0.02 and P = 0.1, respectively; P = 0.8 for interaction), and a significant association was seen for postmenopausal women but not premenopausal women (P = 0.02 and P = 0.2, respectively; P = 0.5 for interaction). Compared with women with serum bicarbonate levels < 24 mEq/L, those with serum bicarbonate levels ≥ 27 mEq/L had 0.018-g/cm2 higher total BMD (95% CI, 0.004-0.032; P = 0.01) and 31% lower odds of having low total bone mass (OR, 0.68; 95% CI, 0.46-0.99; P = 0.049). Limitations Cross-sectional study using a single measurement of serum bicarbonate. Subgroup differences are not definitive. Conclusions Lower serum bicarbonate levels are associated with lower BMD in US adults. Further studies should examine whether serum bicarbonate levels should be incorporated into the diagnostic assessment and management of osteoporosis.
KW - (NHANES)
KW - Examination Survey
KW - National Health and Nutrition
KW - Serum bicarbonate
KW - absorptiometry (DEXA)
KW - acidosis bone mineral density (BMD)
KW - alkali
KW - bone mass modifiable risk factor
KW - dual-energy x-ray
KW - lumbar BMD
KW - osteoporosis low
KW - therapy metabolic
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U2 - 10.1053/j.ajkd.2014.07.007
DO - 10.1053/j.ajkd.2014.07.007
M3 - Article
C2 - 25168294
AN - SCOPUS:84921463284
SN - 0272-6386
VL - 65
SP - 240
EP - 248
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 2
ER -