Serum and follicular fluid monocyte chemotactic protein-1 levels are elevated in obese women and are associated with poorer clinical pregnancy rate after in vitro fertilization: A pilot study

Erkan Buyuk, Obehi A. Asemota, Zaher Merhi, Maureen J. Charron, Dara S. Berger, Athena Zapantis, Sangita K. Jindal

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: To determine whether monocyte chemotactic protein-1 (MCP-1), a proinflammatory chemokine important in ovulation, is abnormally elevated in obese women undergoing IVF and whether serum and follicular fluid (FF) levels of MCP-1 are associated with IVF outcome. Design: Prospective pilot study. Setting: Academic center. Patient(s): Women undergoing IVF. Intervention(s): Serum and FF were collected from women undergoing IVF. Main Outcome Measure(s): Correlation between MCP-1 and other inflammatory markers with adiposity and pregnancy outcome after IVF. Result(s): Obese women had significantly higher serum and FF MCP-1 levels compared with overweight and normal weight women. Serum MCP-1, granulocyte colony stimulating factor, catalase, and C-reactive protein (CRP) were positively correlated with body mass index (BMI). After adjusting for age and baseline FSH, these correlations remained significant for serum MCP-1, granulocyte colony stimulating factor, and CRP. In the FF, only MCP-1 was positively correlated with BMI. Women who became pregnant had significantly lower serum MCP-1 and CRP levels compared with those who did not become pregnant; this difference was more pronounced among women with diminished ovarian reserve. Receiver operating characteristic curve demonstrated that serum MCP-1 levels >373.0 pg/mL in all women and >362.6pg/mL in women with diminished ovarian reserve predicted failure to achieve a clinical pregnancy. Conclusion(s): Elevations in serum and FF MCP-1 levels are positively correlated with adiposity and negatively correlated with pregnancy rates (PRs) in women undergoing IVF.

Original languageEnglish (US)
JournalFertility and Sterility
DOIs
StateAccepted/In press - Nov 1 2016

Fingerprint

Follicular Fluid
Chemokine CCL2
Pregnancy Rate
Fertilization in Vitro
Serum
Blood Proteins
C-Reactive Protein
Adiposity
Granulocyte Colony-Stimulating Factor
Body Mass Index
Pregnancy Outcome
Ovulation
Protein C
Chemokines
ROC Curve
Catalase
Outcome Assessment (Health Care)
Prospective Studies
Weights and Measures

Keywords

  • Follicular fluid
  • IVF
  • MCP-1
  • Obesity
  • Ovary

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

@article{4c9333bfb50446fba092d621e9aeb498,
title = "Serum and follicular fluid monocyte chemotactic protein-1 levels are elevated in obese women and are associated with poorer clinical pregnancy rate after in vitro fertilization: A pilot study",
abstract = "Objective: To determine whether monocyte chemotactic protein-1 (MCP-1), a proinflammatory chemokine important in ovulation, is abnormally elevated in obese women undergoing IVF and whether serum and follicular fluid (FF) levels of MCP-1 are associated with IVF outcome. Design: Prospective pilot study. Setting: Academic center. Patient(s): Women undergoing IVF. Intervention(s): Serum and FF were collected from women undergoing IVF. Main Outcome Measure(s): Correlation between MCP-1 and other inflammatory markers with adiposity and pregnancy outcome after IVF. Result(s): Obese women had significantly higher serum and FF MCP-1 levels compared with overweight and normal weight women. Serum MCP-1, granulocyte colony stimulating factor, catalase, and C-reactive protein (CRP) were positively correlated with body mass index (BMI). After adjusting for age and baseline FSH, these correlations remained significant for serum MCP-1, granulocyte colony stimulating factor, and CRP. In the FF, only MCP-1 was positively correlated with BMI. Women who became pregnant had significantly lower serum MCP-1 and CRP levels compared with those who did not become pregnant; this difference was more pronounced among women with diminished ovarian reserve. Receiver operating characteristic curve demonstrated that serum MCP-1 levels >373.0 pg/mL in all women and >362.6pg/mL in women with diminished ovarian reserve predicted failure to achieve a clinical pregnancy. Conclusion(s): Elevations in serum and FF MCP-1 levels are positively correlated with adiposity and negatively correlated with pregnancy rates (PRs) in women undergoing IVF.",
keywords = "Follicular fluid, IVF, MCP-1, Obesity, Ovary",
author = "Erkan Buyuk and Asemota, {Obehi A.} and Zaher Merhi and Charron, {Maureen J.} and Berger, {Dara S.} and Athena Zapantis and Jindal, {Sangita K.}",
year = "2016",
month = "11",
day = "1",
doi = "10.1016/j.fertnstert.2016.12.023",
language = "English (US)",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Serum and follicular fluid monocyte chemotactic protein-1 levels are elevated in obese women and are associated with poorer clinical pregnancy rate after in vitro fertilization

T2 - A pilot study

AU - Buyuk, Erkan

AU - Asemota, Obehi A.

AU - Merhi, Zaher

AU - Charron, Maureen J.

AU - Berger, Dara S.

AU - Zapantis, Athena

AU - Jindal, Sangita K.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Objective: To determine whether monocyte chemotactic protein-1 (MCP-1), a proinflammatory chemokine important in ovulation, is abnormally elevated in obese women undergoing IVF and whether serum and follicular fluid (FF) levels of MCP-1 are associated with IVF outcome. Design: Prospective pilot study. Setting: Academic center. Patient(s): Women undergoing IVF. Intervention(s): Serum and FF were collected from women undergoing IVF. Main Outcome Measure(s): Correlation between MCP-1 and other inflammatory markers with adiposity and pregnancy outcome after IVF. Result(s): Obese women had significantly higher serum and FF MCP-1 levels compared with overweight and normal weight women. Serum MCP-1, granulocyte colony stimulating factor, catalase, and C-reactive protein (CRP) were positively correlated with body mass index (BMI). After adjusting for age and baseline FSH, these correlations remained significant for serum MCP-1, granulocyte colony stimulating factor, and CRP. In the FF, only MCP-1 was positively correlated with BMI. Women who became pregnant had significantly lower serum MCP-1 and CRP levels compared with those who did not become pregnant; this difference was more pronounced among women with diminished ovarian reserve. Receiver operating characteristic curve demonstrated that serum MCP-1 levels >373.0 pg/mL in all women and >362.6pg/mL in women with diminished ovarian reserve predicted failure to achieve a clinical pregnancy. Conclusion(s): Elevations in serum and FF MCP-1 levels are positively correlated with adiposity and negatively correlated with pregnancy rates (PRs) in women undergoing IVF.

AB - Objective: To determine whether monocyte chemotactic protein-1 (MCP-1), a proinflammatory chemokine important in ovulation, is abnormally elevated in obese women undergoing IVF and whether serum and follicular fluid (FF) levels of MCP-1 are associated with IVF outcome. Design: Prospective pilot study. Setting: Academic center. Patient(s): Women undergoing IVF. Intervention(s): Serum and FF were collected from women undergoing IVF. Main Outcome Measure(s): Correlation between MCP-1 and other inflammatory markers with adiposity and pregnancy outcome after IVF. Result(s): Obese women had significantly higher serum and FF MCP-1 levels compared with overweight and normal weight women. Serum MCP-1, granulocyte colony stimulating factor, catalase, and C-reactive protein (CRP) were positively correlated with body mass index (BMI). After adjusting for age and baseline FSH, these correlations remained significant for serum MCP-1, granulocyte colony stimulating factor, and CRP. In the FF, only MCP-1 was positively correlated with BMI. Women who became pregnant had significantly lower serum MCP-1 and CRP levels compared with those who did not become pregnant; this difference was more pronounced among women with diminished ovarian reserve. Receiver operating characteristic curve demonstrated that serum MCP-1 levels >373.0 pg/mL in all women and >362.6pg/mL in women with diminished ovarian reserve predicted failure to achieve a clinical pregnancy. Conclusion(s): Elevations in serum and FF MCP-1 levels are positively correlated with adiposity and negatively correlated with pregnancy rates (PRs) in women undergoing IVF.

KW - Follicular fluid

KW - IVF

KW - MCP-1

KW - Obesity

KW - Ovary

UR - http://www.scopus.com/inward/record.url?scp=85009380877&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85009380877&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2016.12.023

DO - 10.1016/j.fertnstert.2016.12.023

M3 - Article

C2 - 28104240

AN - SCOPUS:85009380877

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

ER -