Serum and colon mucosa micronutrient antioxidants

Differences between adenomatous polyp patients and controls

Satheesh Nair, Edward P. Norkus, Hilary I. Hertan, C. S. Pitchumoni

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

OBJECTIVES: Micronutrient antioxidants, by virtue of their free radical scavenging properties, are potential chemopreventive agents against colon cancer. Yet, little is known about the actual concentration of these antioxidants in colonic mucosa. It is also not known whether a relationship exists between serum and mucosal tissue antioxidant levels. Previous studies evaluating the occurrence of polyps after supplementation with vitamin E and β-carotene have yielded mixed results. The aim of this study was to determine the concentrations of seven micronutrient antioxidants (α- and γ-tocopherol, lutein, β-cryptoxanthin, lycopene, and α- and β-carotene) in colonic mucosa and to determine whether serum levels of each antioxidant could predict levels of that antioxidant in the right and left colon of patients with normal mucosa or in those with adenomatous polyps. METHODS: Mucosal tissue concentrations and serum levels of antioxidants were determined in 10 patients with adenomatous polyps and 15 control subjects (GI patients with normal colonic mucosa). Mucosal tissue samples were obtained from both the right and left colon in all patients. RESULTS: Patients with polyps similar serum antioxidant status similar to that of control. However, polyp patients had significantly lower concentrations of all seven antioxidants in both the right (p < 0.0070) and left colon (p < 0.0026) than did controls. Finally, serum antioxidant levels predict right and left colon antioxidant levels in controls but not in patients with polyps. CONCLUSIONS: Patients with adenomatous polyps have low levels of micronutrient antioxidants in their colon mucosa. Because the serum levels of these antioxidants were similar in controls and polyp patients, our findings suggest an increased level of free radical activity in patients with polyps compared to normal subjects.

Original languageEnglish (US)
Pages (from-to)3400-3405
Number of pages6
JournalAmerican Journal of Gastroenterology
Volume96
Issue number12
DOIs
StatePublished - 2001
Externally publishedYes

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Adenomatous Polyps
Micronutrients
Colon
Mucous Membrane
Antioxidants
Serum
Polyps
Carotenoids
Free Radicals
Lutein
Tocopherols
Vitamin E
Colonic Neoplasms

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Serum and colon mucosa micronutrient antioxidants : Differences between adenomatous polyp patients and controls. / Nair, Satheesh; Norkus, Edward P.; Hertan, Hilary I.; Pitchumoni, C. S.

In: American Journal of Gastroenterology, Vol. 96, No. 12, 2001, p. 3400-3405.

Research output: Contribution to journalArticle

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abstract = "OBJECTIVES: Micronutrient antioxidants, by virtue of their free radical scavenging properties, are potential chemopreventive agents against colon cancer. Yet, little is known about the actual concentration of these antioxidants in colonic mucosa. It is also not known whether a relationship exists between serum and mucosal tissue antioxidant levels. Previous studies evaluating the occurrence of polyps after supplementation with vitamin E and β-carotene have yielded mixed results. The aim of this study was to determine the concentrations of seven micronutrient antioxidants (α- and γ-tocopherol, lutein, β-cryptoxanthin, lycopene, and α- and β-carotene) in colonic mucosa and to determine whether serum levels of each antioxidant could predict levels of that antioxidant in the right and left colon of patients with normal mucosa or in those with adenomatous polyps. METHODS: Mucosal tissue concentrations and serum levels of antioxidants were determined in 10 patients with adenomatous polyps and 15 control subjects (GI patients with normal colonic mucosa). Mucosal tissue samples were obtained from both the right and left colon in all patients. RESULTS: Patients with polyps similar serum antioxidant status similar to that of control. However, polyp patients had significantly lower concentrations of all seven antioxidants in both the right (p < 0.0070) and left colon (p < 0.0026) than did controls. Finally, serum antioxidant levels predict right and left colon antioxidant levels in controls but not in patients with polyps. CONCLUSIONS: Patients with adenomatous polyps have low levels of micronutrient antioxidants in their colon mucosa. Because the serum levels of these antioxidants were similar in controls and polyp patients, our findings suggest an increased level of free radical activity in patients with polyps compared to normal subjects.",
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