Serum albumin is a powerful predictor of survival among HIV-1-infected women

Joseph G. Feldman, Stephen J. Gange, Peter Bacchetti, Mardge Cohen, Mary Young, Katheleen E. Squires, Carolyn Williams, Philip Goldwasser, Kathryn Anastos

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Background: We previously reported that single measurements of albumin strongly predict survival in HIV-1-infected women independent of disease-specific markers. We now extend this to the use of serial measurements and single albumin values prior to initiation of highly active antiretroviral therapy. Design: Prospective cohort study of 1941 women enrolled at six sites in the Women's Interagency HIV Study. Results: Albumin fell 0.44 g/L/y in 1627 women who survived and at a faster rate in 397 who died (1.54 g/L/y; p < .01). In a time-dependent model adjusting for disease markers, the relative hazard (RH) was fivefold higher in patients with serum albumin <35 g/L compared with patients with serum albumin ≥42 g/L. The RH of serum albumin <35 g/L in women with CD4+ lymphocyte counts ≥200 cells/μL was 8.2 [95% CI: 4.2-15.8]) versus only 3.8 [95% CI: 2.4-6.1] in those with counts <200 cells/mm3. In a fixed-covariate Cox analysis of patients who started HAART during the study, albumin prior to HAART was associated with a higher RH (7.0 for albumin <35 g/L versus >42 g/L) than were other factors. Conclusion: Serum albumin is a strong independent predictor of mortality in HIV-1-infected women after adjustment for known disease markers and may be useful for clinical monitoring.

Original languageEnglish (US)
Pages (from-to)66-73
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes
Volume33
Issue number1
StatePublished - May 1 2003

Fingerprint

Serum Albumin
HIV-1
Survival
Albumins
Highly Active Antiretroviral Therapy
Cohort Studies
HIV
Prospective Studies
Mortality

Keywords

  • HAART
  • HIV trends in serum albumin
  • Independent predictor of survival
  • Time-dependent model

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Feldman, J. G., Gange, S. J., Bacchetti, P., Cohen, M., Young, M., Squires, K. E., ... Anastos, K. (2003). Serum albumin is a powerful predictor of survival among HIV-1-infected women. Journal of Acquired Immune Deficiency Syndromes, 33(1), 66-73.

Serum albumin is a powerful predictor of survival among HIV-1-infected women. / Feldman, Joseph G.; Gange, Stephen J.; Bacchetti, Peter; Cohen, Mardge; Young, Mary; Squires, Katheleen E.; Williams, Carolyn; Goldwasser, Philip; Anastos, Kathryn.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 33, No. 1, 01.05.2003, p. 66-73.

Research output: Contribution to journalArticle

Feldman, JG, Gange, SJ, Bacchetti, P, Cohen, M, Young, M, Squires, KE, Williams, C, Goldwasser, P & Anastos, K 2003, 'Serum albumin is a powerful predictor of survival among HIV-1-infected women', Journal of Acquired Immune Deficiency Syndromes, vol. 33, no. 1, pp. 66-73.
Feldman JG, Gange SJ, Bacchetti P, Cohen M, Young M, Squires KE et al. Serum albumin is a powerful predictor of survival among HIV-1-infected women. Journal of Acquired Immune Deficiency Syndromes. 2003 May 1;33(1):66-73.
Feldman, Joseph G. ; Gange, Stephen J. ; Bacchetti, Peter ; Cohen, Mardge ; Young, Mary ; Squires, Katheleen E. ; Williams, Carolyn ; Goldwasser, Philip ; Anastos, Kathryn. / Serum albumin is a powerful predictor of survival among HIV-1-infected women. In: Journal of Acquired Immune Deficiency Syndromes. 2003 ; Vol. 33, No. 1. pp. 66-73.
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