Serum 25-hydroxyvitamin D concentration is associated with functional capacity in older adults with heart failure

Rebecca S. Boxer, Anne M. Kenny, Vinay K. Cheruvu, Marianne Vest, Justin J. Fiutem, Ileana L. Pina

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: Vitamin D is a fat-soluble hormone necessary for calcium homeostasis. Recently, studies have demonstrated that vitamin D may be important to the health of the cardiovascular system. Methods: Adults ≥50 years of age with heart failure were recruited for assessment of serum 25-hydroxyvitamin D (25OHD) concentrations. Cardiopulmonary exercise testing was used to assess functional capacity. Proximal muscle strength was evaluated with a Biodex leg press (Biodex, Shirley, NY), and health status was assessed with the Kansas City Cardiomyopathy Questionnaire. Univariate associations between physical performance and health status measures and 25OHD followed by a linear regression model were used to study associations, adjusting for other potential explanatory variables. Results: Forty adults 67.8 ± 10.9 years of age (55% women and 57.5% African American) with mean ejection fraction 40% were analyzed (New York Heart Association class II in 70% and class III in 30%). Comorbidities included 77.5% hypertension and 47.5% diabetes. The mean 25OHD concentration was 18.5 ± 9.1 ng/mL, and mean peak Vo2, 14 ± 4 mL/kg/min. In univariate regression analysis, 25OHD was positively associated with peak Vo2 (P = .045). Multivariable regression analysis sustained positive association between 25OHD and peak Vo2 (P = .044) after adjusting for age, race, and respiratory exchange ratio (adjusted R2 = 0.32). Association between proximal muscle strength with the 25OHD concentration was not significant. The Kansas City Cardiomyopathy Questionnaire physical limitation domain score was negatively associated with 25OHD (P = .04) but was not sustained in multivariable analysis. Conclusions: 25-Hydroxyvitamin D may be an important marker or modulator of functional capacity in patients with heart failure. Randomized controlled trials are needed to assess the effect of vitamin D repletion on functional performance.

Original languageEnglish (US)
Pages (from-to)893-899
Number of pages7
JournalAmerican Heart Journal
Volume160
Issue number5
DOIs
StatePublished - Nov 2010
Externally publishedYes

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Vitamin D
Heart Failure
Muscle Strength
Cardiomyopathies
Health Status
Linear Models
Serum
Regression Analysis
Cardiovascular System
African Americans
Comorbidity
Leg
Homeostasis
Randomized Controlled Trials
Fats
Hormones
Exercise
Hypertension
Calcium
Health

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Serum 25-hydroxyvitamin D concentration is associated with functional capacity in older adults with heart failure. / Boxer, Rebecca S.; Kenny, Anne M.; Cheruvu, Vinay K.; Vest, Marianne; Fiutem, Justin J.; Pina, Ileana L.

In: American Heart Journal, Vol. 160, No. 5, 11.2010, p. 893-899.

Research output: Contribution to journalArticle

Boxer, Rebecca S. ; Kenny, Anne M. ; Cheruvu, Vinay K. ; Vest, Marianne ; Fiutem, Justin J. ; Pina, Ileana L. / Serum 25-hydroxyvitamin D concentration is associated with functional capacity in older adults with heart failure. In: American Heart Journal. 2010 ; Vol. 160, No. 5. pp. 893-899.
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AU - Fiutem, Justin J.

AU - Pina, Ileana L.

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