Sertraline hepatotoxicity: A case report and review of the literature on selective serotonin reuptake inhibitor hepatotoxicity

Seth Persky, John F. Reinus

Research output: Contribution to journalArticle

27 Scopus citations


The causal role of sertraline in rare cases of liver failure in patients taking the drug has not been proven in a manner consistent with usually accepted standards. We describe an individual who developed clinically significant hepatitis while being treated with sertraline. This case is significant because it is the only one of which we are aware in which the diagnosis of sertraline hepatotoxicity was confirmed when inadvertent rechallenge with the medication resulted in recurrent hepatitis. We review this case and the general role of this widely prescribed class of drugs in causing hepatitis.

Original languageEnglish (US)
Pages (from-to)939-944
Number of pages6
JournalDigestive Diseases and Sciences
Issue number5
Publication statusPublished - May 1 2003



  • Hepatitis
  • Hepatotoxicity
  • SSRI
  • Sertraline
  • Zoloft

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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