Abstract
This study investigated the relationship between increased serotonin (5-hydroxytryptamine, 5HT) receptor sensitivity and human aggression. A low oral dose of meta-chlorophenylpiperazine (MCPP), a postsynaptics 5HT receptor agonist, was administered in a placebo-controlled design to depressed (n = 22) and panic disorder (n = 20) patients classified with or wothout signs of outwardly directed aggression, patients with a history of suicide attemps (inwardly directed aggression) (n = 11), and normal controls (n = 19). Hormones under 5HT control were measured at 30-min intervals. Results were as follows: (1) MCPP did not induce or reduce anger, (2) patients with outwardly directed aggression did not have significantly greater MCPP-induced cortisol or prolactin release than did patients without signs of outwardly directed aggression, (3) patients with a history of suicide attemps did not have significantly greater MCPP-induced cortisol or prolactin release than did normal controls, and (4) MCPP-induced hormone release was unrelated to measures of aggression.
Original language | English (US) |
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Pages (from-to) | 271-279 |
Number of pages | 9 |
Journal | Psychiatry Research |
Volume | 37 |
Issue number | 3 |
DOIs | |
State | Published - Jun 1991 |
Keywords
- Meta-chlorophenylpiperazine
- depression
- panic disorder
- suicidality
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry