@article{31c9ed64c5074ad496766a4458f5fb15,
title = "Serotonin Mediates Cross-Modal Reorganization of Cortical Circuits",
abstract = "Loss of one type of sensory input can cause improved functionality of other sensory systems. Whereas this form of plasticity, cross-modal plasticity, is well established, the molecular and cellular mechanisms underlying it are still unclear. Here, we show that visual deprivation (VD) increases extracellular serotonin in the juvenile rat barrel cortex. This increase in serotonin levels facilitates synaptic strengthening at layer 4 to layer 2/3 synapses within the barrel cortex. Upon VD, whisker experience leads to trafficking of the AMPA-type glutamate receptors (AMPARs) into these synapses through the activation of ERK and increased phosphorylation of AMPAR subunit GluR1 at the juvenile age when natural whisker experience no longer induces synaptic GluR1 delivery. VD thereby leads to sharpening of the functional whisker-barrel map at layer 2/3. Thus, sensory deprivation of one modality leads to serotonin release in remaining modalities, facilitates GluR1-dependent synaptic strengthening, and refines cortical organization.",
author = "Susumu Jitsuki and Kiwamu Takemoto and Taisuke Kawasaki and Hirobumi Tada and Aoi Takahashi and Carine Becamel and Akane Sano and Michisuke Yuzaki and Zukin, {R. Suzanne} and Ziff, {Edward B.} and Kessels, {Helmut W.} and Takuya Takahashi",
note = "Funding Information: This project was supported by JST,CREST (T.T.), Special Coordination Funds for Promoting Science and Technology (T.T.), “Development of biomarker candidates for social behavior” carried out under the Strategic Research Program for Brain Sciences by the Ministry of Education, Culture, Sports,Science and Technology of Japan (TT), and Ishidsu Shun Memorial Scholarship (S.J.). We thank Dr. Philippe Marin (Institute de g{\'e}nomique fonctionnelle) for supporting the short hairpin constructs and characterization in his laboratory. We thank Yoshiko Kanno and Yoshinori Kamiya for technical assistance. We thank Dr. Hiroyuki Miyoshi and Atsushi Miyawaki (RIKEN) for providing Lenti-virus vector. We thank Kenkichi Takase Himeji Dokkyo) for discussion. We also thank Yasunori Hayashi (RIKEN) and Jose Esteban (CSIC) for critically reading the manuscript. ",
year = "2011",
month = feb,
day = "24",
doi = "10.1016/j.neuron.2011.01.016",
language = "English (US)",
volume = "69",
pages = "780--792",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "4",
}