Abstract
A high prevalence of comorbidity has been reported between migraines and psychiatric disorders. It has been proposed that migraine headaches are mediated by stimulation of serotonin (5-HT) receptors. Past studies have demonstrated that migraine-like headaches have been produced following administration of the partial 5-HT agonist m-chlorophenylpiperazine (m-CPP; believed to primarily affect the 5-HT2C receptor) in patients with migraines or eating disorders, especially bulimia, as well as in normal controls. We review the association between 5-HT dysfunction, as determined by response to m-CPP challenge, and migraines, looking specifically at the relationship between migraines and obsessive-compulsive disorder and gender effects.
Original language | English (US) |
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Pages (from-to) | 25-27 |
Number of pages | 3 |
Journal | CNS spectrums |
Volume | 2 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health