Serotonin-1D hypothesis of obsessive-compulsive disorder: An update

Joseph Zohar; James L. Kennedy; Eric Hollander; Lorrin M. Koran

Serotonin-1D hypothesis of obsessive-compulsive disorder: An update

Joseph Zohar, James L. Kennedy, Eric Hollander, Lorrin M. Koran

Research output: Contribution to journal › Review article › peer-review

Abstract

Support for the serotonin-1D (5-HT_1D) hypothesis of obsessive-compulsive disorder (OCD) and related conditions comes from a variety of sources. Some pharmacologic challenges with the 5-HT_1D agonist sumatriptan, and case reports in which prolonged administration of 5-HT _1D agonists was associated with a therapeutic effect, suggest that 5-HT_1D may play a role in obsessive-compulsive symptoms. Genetic studies have also found that polymorphism of the 5-HT_1D gene may be preferentially transmitted to those patients with OCD. However, taking into account that OCD is a heterogeneous syndrome, the 5-HT_1D hypothesis requires further investigation in order to disentangle the role of the 5-HT _1D receptor in this common and often severe disorder.

Original language	English (US)
Pages (from-to)	18-21
Number of pages	4
Journal	Journal of Clinical Psychiatry
Volume	65
Issue number	SUPPL. 14
State	Published - 2004
Externally published	Yes

ASJC Scopus subject areas

Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Serotonin-1D hypothesis of obsessive-compulsive disorder: An update",

abstract = "Support for the serotonin-1D (5-HT1D) hypothesis of obsessive-compulsive disorder (OCD) and related conditions comes from a variety of sources. Some pharmacologic challenges with the 5-HT1D agonist sumatriptan, and case reports in which prolonged administration of 5-HT 1D agonists was associated with a therapeutic effect, suggest that 5-HT1D may play a role in obsessive-compulsive symptoms. Genetic studies have also found that polymorphism of the 5-HT1D gene may be preferentially transmitted to those patients with OCD. However, taking into account that OCD is a heterogeneous syndrome, the 5-HT1D hypothesis requires further investigation in order to disentangle the role of the 5-HT 1D receptor in this common and often severe disorder.",

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AU - Zohar, Joseph

AU - Kennedy, James L.

AU - Hollander, Eric

AU - Koran, Lorrin M.

PY - 2004

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N2 - Support for the serotonin-1D (5-HT1D) hypothesis of obsessive-compulsive disorder (OCD) and related conditions comes from a variety of sources. Some pharmacologic challenges with the 5-HT1D agonist sumatriptan, and case reports in which prolonged administration of 5-HT 1D agonists was associated with a therapeutic effect, suggest that 5-HT1D may play a role in obsessive-compulsive symptoms. Genetic studies have also found that polymorphism of the 5-HT1D gene may be preferentially transmitted to those patients with OCD. However, taking into account that OCD is a heterogeneous syndrome, the 5-HT1D hypothesis requires further investigation in order to disentangle the role of the 5-HT 1D receptor in this common and often severe disorder.

AB - Support for the serotonin-1D (5-HT1D) hypothesis of obsessive-compulsive disorder (OCD) and related conditions comes from a variety of sources. Some pharmacologic challenges with the 5-HT1D agonist sumatriptan, and case reports in which prolonged administration of 5-HT 1D agonists was associated with a therapeutic effect, suggest that 5-HT1D may play a role in obsessive-compulsive symptoms. Genetic studies have also found that polymorphism of the 5-HT1D gene may be preferentially transmitted to those patients with OCD. However, taking into account that OCD is a heterogeneous syndrome, the 5-HT1D hypothesis requires further investigation in order to disentangle the role of the 5-HT 1D receptor in this common and often severe disorder.

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Serotonin-1D hypothesis of obsessive-compulsive disorder: An update

Abstract

ASJC Scopus subject areas

UN SDGs

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