Serotonin-1D hypothesis of obsessive-compulsive disorder

An update

Joseph Zohar, James L. Kennedy, Eric Hollander, Lorrin M. Koran

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Support for the serotonin-1D (5-HT1D) hypothesis of obsessive-compulsive disorder (OCD) and related conditions comes from a variety of sources. Some pharmacologic challenges with the 5-HT1D agonist sumatriptan, and case reports in which prolonged administration of 5-HT 1D agonists was associated with a therapeutic effect, suggest that 5-HT1D may play a role in obsessive-compulsive symptoms. Genetic studies have also found that polymorphism of the 5-HT1D gene may be preferentially transmitted to those patients with OCD. However, taking into account that OCD is a heterogeneous syndrome, the 5-HT1D hypothesis requires further investigation in order to disentangle the role of the 5-HT 1D receptor in this common and often severe disorder.

Original languageEnglish (US)
Pages (from-to)18-21
Number of pages4
JournalJournal of Clinical Psychiatry
Volume65
Issue numberSUPPL. 14
StatePublished - 2004
Externally publishedYes

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Obsessive-Compulsive Disorder
Serotonin
Receptor, Serotonin, 5-HT1D
Serotonin 5-HT1 Receptor Agonists
Sumatriptan
Serotonin Receptor Agonists
Therapeutic Uses
Genes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Zohar, J., Kennedy, J. L., Hollander, E., & Koran, L. M. (2004). Serotonin-1D hypothesis of obsessive-compulsive disorder: An update. Journal of Clinical Psychiatry, 65(SUPPL. 14), 18-21.

Serotonin-1D hypothesis of obsessive-compulsive disorder : An update. / Zohar, Joseph; Kennedy, James L.; Hollander, Eric; Koran, Lorrin M.

In: Journal of Clinical Psychiatry, Vol. 65, No. SUPPL. 14, 2004, p. 18-21.

Research output: Contribution to journalArticle

Zohar, J, Kennedy, JL, Hollander, E & Koran, LM 2004, 'Serotonin-1D hypothesis of obsessive-compulsive disorder: An update', Journal of Clinical Psychiatry, vol. 65, no. SUPPL. 14, pp. 18-21.
Zohar, Joseph ; Kennedy, James L. ; Hollander, Eric ; Koran, Lorrin M. / Serotonin-1D hypothesis of obsessive-compulsive disorder : An update. In: Journal of Clinical Psychiatry. 2004 ; Vol. 65, No. SUPPL. 14. pp. 18-21.
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