Serotonergic sensitivity in borderline personality disorder

Preliminary findings

Eric Hollander, Dan J. Stein, Concetta M. DeCaria, Lisa Cohen, Jihad B. Saoud, Andrew E. Skodol, David Kellman, Lyle Rosnick, John M. Oldham

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Twelve patients with borderline personality disorder and 15 healthy comparison subjects were challenged with single doses of oral m- chlorophenylpiperazine (m-CPP) and placebo. Following m-CPP, the patients experienced decreased anger and fear. Seven of the 12 patients reported a 'spacy,' 'high,' depersonalized/derealized experience following m-CPP, which was confirmed by clinicians' ratings. Compared with the normal male subjects, the male patients with borderline personality disorder had higher cortisol levels and marginally blunted prolactin responses after receiving m-CPP. These results suggest serotonergic dysfunction in borderline personality disorder.

Original languageEnglish (US)
Pages (from-to)277-280
Number of pages4
JournalAmerican Journal of Psychiatry
Volume151
Issue number2
StatePublished - Feb 1994
Externally publishedYes

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Borderline Personality Disorder
Anger
Prolactin
Fear
Hydrocortisone
Healthy Volunteers
Placebos
1-(3-chlorophenyl)piperazine

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Hollander, E., Stein, D. J., DeCaria, C. M., Cohen, L., Saoud, J. B., Skodol, A. E., ... Oldham, J. M. (1994). Serotonergic sensitivity in borderline personality disorder: Preliminary findings. American Journal of Psychiatry, 151(2), 277-280.

Serotonergic sensitivity in borderline personality disorder : Preliminary findings. / Hollander, Eric; Stein, Dan J.; DeCaria, Concetta M.; Cohen, Lisa; Saoud, Jihad B.; Skodol, Andrew E.; Kellman, David; Rosnick, Lyle; Oldham, John M.

In: American Journal of Psychiatry, Vol. 151, No. 2, 02.1994, p. 277-280.

Research output: Contribution to journalArticle

Hollander, E, Stein, DJ, DeCaria, CM, Cohen, L, Saoud, JB, Skodol, AE, Kellman, D, Rosnick, L & Oldham, JM 1994, 'Serotonergic sensitivity in borderline personality disorder: Preliminary findings', American Journal of Psychiatry, vol. 151, no. 2, pp. 277-280.
Hollander E, Stein DJ, DeCaria CM, Cohen L, Saoud JB, Skodol AE et al. Serotonergic sensitivity in borderline personality disorder: Preliminary findings. American Journal of Psychiatry. 1994 Feb;151(2):277-280.
Hollander, Eric ; Stein, Dan J. ; DeCaria, Concetta M. ; Cohen, Lisa ; Saoud, Jihad B. ; Skodol, Andrew E. ; Kellman, David ; Rosnick, Lyle ; Oldham, John M. / Serotonergic sensitivity in borderline personality disorder : Preliminary findings. In: American Journal of Psychiatry. 1994 ; Vol. 151, No. 2. pp. 277-280.
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