Serotonergic sensitivity in borderline personality disorder: Preliminary findings

Eric Hollander, Dan J. Stein, Concetta M. DeCaria, Lisa Cohen, Jihad B. Saoud, Andrew E. Skodol, David Kellman, Lyle Rosnick, John M. Oldham

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

Twelve patients with borderline personality disorder and 15 healthy comparison subjects were challenged with single doses of oral m- chlorophenylpiperazine (m-CPP) and placebo. Following m-CPP, the patients experienced decreased anger and fear. Seven of the 12 patients reported a 'spacy,' 'high,' depersonalized/derealized experience following m-CPP, which was confirmed by clinicians' ratings. Compared with the normal male subjects, the male patients with borderline personality disorder had higher cortisol levels and marginally blunted prolactin responses after receiving m-CPP. These results suggest serotonergic dysfunction in borderline personality disorder.

Original languageEnglish (US)
Pages (from-to)277-280
Number of pages4
JournalAmerican Journal of Psychiatry
Volume151
Issue number2
DOIs
StatePublished - Feb 1994
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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