Serotonergic function in obsessive-compulsive disorder

Behavioral and neuroendocrine responses to oral m-chlorophenylpiperazine and fenfluramine in patients and healthy volunteers

Eric Hollander, Concerta M. DeCaria, Anca Nitescu, Robert Gully, Raymond F. Suckow, Thomas B. Cooper, Jack M. Gorman, Donald F. Klein, Michael R. Liebowitz

Research output: Contribution to journalArticle

232 Citations (Scopus)

Abstract

To evaluate serotonergic (5-hydroxytryptamine) function in obsessive-compulsive disorder, behavioral and neuroendocrine responses to m-chlorophenylpiperazine (m-CPP; 0.5 mg/kg orally) and fenfluramine hydrochloride (60 mg orally) were examined in 20 patients and 10 healthy controls under double-blind, placebo-controlled conditions. Following m-CPP, but not fenfluramine or placebo, 55% (11/20) of the patients with obsessive-compulsive disorder experienced a transient exacerbation of obsessive-compulsive disorder. Prolactin response was blunted in patients following m-CPP but not following fenfluramine. Patients with greater behavioral response to m-CPP had smaller prolactin responses. Cortisol response to m-CPP and fenfluramine did not significantly differ between the groups. Behavioral and neuroendocrine responses appeared divergent. This does not suggest simply upregulation or downregulation of 5-hydroxytryptamine receptors, but rather complex mechanisms involving multiple neurotransmitter and neuromodulator systems.

Original languageEnglish (US)
Pages (from-to)21-28
Number of pages8
JournalArchives of General Psychiatry
Volume49
Issue number1
StatePublished - 1992
Externally publishedYes

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Fenfluramine
Obsessive-Compulsive Disorder
Healthy Volunteers
Prolactin
Neurotransmitter Agents
Placebos
Serotonin Receptors
Hydrocortisone
1-(3-chlorophenyl)piperazine
Serotonin
Up-Regulation
Down-Regulation

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Serotonergic function in obsessive-compulsive disorder : Behavioral and neuroendocrine responses to oral m-chlorophenylpiperazine and fenfluramine in patients and healthy volunteers. / Hollander, Eric; DeCaria, Concerta M.; Nitescu, Anca; Gully, Robert; Suckow, Raymond F.; Cooper, Thomas B.; Gorman, Jack M.; Klein, Donald F.; Liebowitz, Michael R.

In: Archives of General Psychiatry, Vol. 49, No. 1, 1992, p. 21-28.

Research output: Contribution to journalArticle

Hollander, Eric ; DeCaria, Concerta M. ; Nitescu, Anca ; Gully, Robert ; Suckow, Raymond F. ; Cooper, Thomas B. ; Gorman, Jack M. ; Klein, Donald F. ; Liebowitz, Michael R. / Serotonergic function in obsessive-compulsive disorder : Behavioral and neuroendocrine responses to oral m-chlorophenylpiperazine and fenfluramine in patients and healthy volunteers. In: Archives of General Psychiatry. 1992 ; Vol. 49, No. 1. pp. 21-28.
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