Serotonergic and noradrenergic sensitivity in obsessive-compulsive disorder

behavioral findings

Eric Hollander, M. Fay, B. Cohen, R. Campeas, J. M. Gorman, M. R. Liebowitz

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

Six of eight patients with obsessive-compulsive disorder had an exacerbation of symptoms when given m-chlorophenylpiperazine. Fenfluramine and placebo produced mild improvement. Six patients given intravenous clonidine experienced marked reduction in obsessions. Implications for serotonergic and noradrenergic hypotheses of obsessive-compulsive disorder are discussed.

Original languageEnglish (US)
Pages (from-to)1015-1017
Number of pages3
JournalAmerican Journal of Psychiatry
Volume145
Issue number8
StatePublished - 1988
Externally publishedYes

Fingerprint

Obsessive-Compulsive Disorder
Fenfluramine
Obsessive Behavior
Clonidine
Placebos
1-(3-chlorophenyl)piperazine

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Hollander, E., Fay, M., Cohen, B., Campeas, R., Gorman, J. M., & Liebowitz, M. R. (1988). Serotonergic and noradrenergic sensitivity in obsessive-compulsive disorder: behavioral findings. American Journal of Psychiatry, 145(8), 1015-1017.

Serotonergic and noradrenergic sensitivity in obsessive-compulsive disorder : behavioral findings. / Hollander, Eric; Fay, M.; Cohen, B.; Campeas, R.; Gorman, J. M.; Liebowitz, M. R.

In: American Journal of Psychiatry, Vol. 145, No. 8, 1988, p. 1015-1017.

Research output: Contribution to journalArticle

Hollander, E, Fay, M, Cohen, B, Campeas, R, Gorman, JM & Liebowitz, MR 1988, 'Serotonergic and noradrenergic sensitivity in obsessive-compulsive disorder: behavioral findings', American Journal of Psychiatry, vol. 145, no. 8, pp. 1015-1017.
Hollander, Eric ; Fay, M. ; Cohen, B. ; Campeas, R. ; Gorman, J. M. ; Liebowitz, M. R. / Serotonergic and noradrenergic sensitivity in obsessive-compulsive disorder : behavioral findings. In: American Journal of Psychiatry. 1988 ; Vol. 145, No. 8. pp. 1015-1017.
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