Serotonergic and noradrenergic sensitivity in obsessive-compulsive disorder: behavioral findings

E. Hollander; M. Fay; B. Cohen; R. Campeas; J. M. Gorman; M. R. Liebowitz

doi:10.1176/ajp.145.8.1015

Serotonergic and noradrenergic sensitivity in obsessive-compulsive disorder: behavioral findings

E. Hollander, M. Fay, B. Cohen, R. Campeas, J. M. Gorman, M. R. Liebowitz

Research output: Contribution to journal › Article › peer-review

131 Scopus citations

Abstract

Six of eight patients with obsessive-compulsive disorder had an exacerbation of symptoms when given m-chlorophenylpiperazine. Fenfluramine and placebo produced mild improvement. Six patients given intravenous clonidine experienced marked reduction in obsessions. Implications for serotonergic and noradrenergic hypotheses of obsessive-compulsive disorder are discussed.

Original language	English (US)
Pages (from-to)	1015-1017
Number of pages	3
Journal	American Journal of Psychiatry
Volume	145
Issue number	8
DOIs	https://doi.org/10.1176/ajp.145.8.1015
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1176/ajp.145.8.1015

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AU - Gorman, J. M.

AU - Liebowitz, M. R.

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Serotonergic and noradrenergic sensitivity in obsessive-compulsive disorder: behavioral findings

Abstract

ASJC Scopus subject areas

UN SDGs

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