Serotonergic and noradrenergic sensitivity in obsessive-compulsive disorder: behavioral findings

E. Hollander, M. Fay, B. Cohen, R. Campeas, J. M. Gorman, M. R. Liebowitz

Research output: Contribution to journalArticle

123 Scopus citations


Six of eight patients with obsessive-compulsive disorder had an exacerbation of symptoms when given m-chlorophenylpiperazine. Fenfluramine and placebo produced mild improvement. Six patients given intravenous clonidine experienced marked reduction in obsessions. Implications for serotonergic and noradrenergic hypotheses of obsessive-compulsive disorder are discussed.

Original languageEnglish (US)
Pages (from-to)1015-1017
Number of pages3
JournalAmerican Journal of Psychiatry
Issue number8
Publication statusPublished - Jan 1 1988
Externally publishedYes


ASJC Scopus subject areas

  • Psychiatry and Mental health

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